Results 81 to 90 of about 50,970 (263)

Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats

BMC Pharmacology and Toxicology, 2015
Chronic nitroglycerin (GTN) anti-ischemic therapy induces side effects such as nitrate tolerance and endothelial dysfunction. Both phenomena could be based on a desensitization/oxidation of the soluble guanylyl cyclase (sGC). Therefore, the present study
A. Jabs, M. Oelze, Y. Mikhed, Paul Stamm, Swenja Kröller-Schön, Philipp Welschof, T. Jansen, M. Hausding, Maximilian Kopp, S. Steven, Eberhard Schulz, J. Stasch, T. Münzel, A. Daiber   +13 more
semanticscholar   +1 more source

Feasibility, Safety, and Efficacy of Pulsed Field Ablation for Ventricular Arrhythmias: Insights From a Large Health System Registry in the United States

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Pulsed field ablation (PFA) is an emerging non‐thermal ablation modality with proven safety in atrial arrhythmia ablation. However, data on its performance for ventricular arrhythmias (VA) remain limited. Objective To evaluate the feasibility, safety, and efficacy of PFA for complex VA in a multicenter real‐world US registry ...
Narut Prasitlumkum, Juan F. Rodriguez‐Riascos, Hema Vemulapalli, Aakash Somappa, Camilo A. Estrada‐Vargas, Olubadewa A. Fatunde, Carlos A. Rojas, Poojan Prajapati, Keerthika Vijayakumar, Suraj Kapa, Duy Nguyen, Samuel Asirvatham, Malini Madhavan, Christopher McLeod, Hicham Z. El Masry, Abhishek J. Deshmukh, Danesh K. Kella, Ammar M. Killu, Siva K. Mulpuru, Mayank Sardana, Luis R. Scott, Alan M. Sugrue, Komandoor Srivathsan   +22 more
wiley   +1 more source

Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine.

, 1986
Previous studies have suggested that (1) nitroglycerin causes vasodilatation by interacting with sulfhydryl groups in vascular smooth muscle, thereby activating guanylate cyclase and increasing the intracellular concentration of cyclic GMP, and (2) N ...
M D Winniford, L D Hillis, P J Wells, P L Kennedy   +3 more
core   +1 more source

Tilt Table Testing in Paediatric Orthostatic Intolerance: Is 10 Min Long Enough?

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Recent cardiovascular literature suggests that orthostatic testing protocols should be tailored according to diagnostic purpose, distinguishing syncope evaluation from assessment of autonomic dysfunction in chronic orthostatic intolerance (COI).
Wonshik Choi, Sin Weon Yun
wiley   +1 more source

CamKIIα and VPAC1 Expressions in the Caudal Trigeminal Nucleus of Rats After Systemic Nitroglycerin Treatment: Interaction with Anandamide

Life
Migraines are a frequently occurring neurological condition that affects up to 16% of the global population. The precise pathomechanism of the disease remains unknown, but from animal and human observations, it appears that calcium/calmodulin-dependent ...
Gábor Nagy-Grócz, Eleonóra Spekker, Tamás Körtési, Klaudia Flóra Laborc, Zsuzsanna Bohár, Annamária Fejes-Szabó, László Vécsei, Árpád Párdutz   +7 more
doaj   +1 more source

Safety of Pulsed Field Ablation: Established Evidence, Emerging Risks, and Knowledge Gaps

Pacing and Clinical Electrophysiology, EarlyView.
Overview of the safety profile of pulsed field ablation (PFA), highlighting established safety advantages, procedure‐related complications, electroporation‐specific effects, and key areas of ongoing uncertainty, particularly for ventricular applications.
Dakota de Cecco, Jeanne du Fay de Lavallaz, Boldizsar Kovacs, Jackson J. Liang   +3 more
wiley   +1 more source

Action of intracoronary nitroglycerin in refractory coronary artery spasm.

, 1982
Coronary artery spasm usually responds to sublingual nitroglycerin. This report describes four patients with variant angina and one patient with rest angina who had coronary spasm that was refractory to sublingual or i.v. nitroglycerin. In four patients,
C R Conti, C J Pepine, R L Feldman
core   +1 more source

Nitroglycerin Administration Trim Project [PDF]

, 2016
Description/Background: In the USA, angina affects 10.2 million people with Coronary Artery Disease (CAD) (Sansone, 2010). CAD is the leading cause of death with chest pain being its primary manifestation (Gallagher, 2010).
Filomeno, Rosa
core   +1 more source

Geographical distribution of ALDH2 rs671 polymorphism in Chinese angina pectoris patients

Frontiers in Genetics
BackgroundMitochondrial acetaldehyde dehydrogenase 2 (ALDH2) plays a critical role in the metabolism of ethanol and nitroglycerin. Mutations in ALDH2 reduce enzymatic activity, impairing nitroglycerin metabolism.
Wenjia Dong, Junjie Yu, Siqi Xu, Hongsheng Li   +3 more
doaj   +1 more source

Effects of subcutaneously infiltrated nitroglycerin on diameter, palpability, ease-of-puncture and pre-cannulation spasm of radial artery during transradial coronary angiography.

Indian Heart Journal, 2014
BACKGROUND The success of transradial catheterization depends on meticulous access of radial artery which in turn depends on palpating a good radial pulse.
B. Ezhumalai, S. Satheesh, B. Jayaraman
semanticscholar   +1 more source