Results 91 to 100 of about 5,742 (217)

Studies on antiparasitic agents: effect of the lactam nucleus substitution in the 2-position on the in-vitro activity of new 5-nitroimidazoles

, 1991
The in-vitro antiprotozoal activity of a series of new 5-nitroimidazoles substituted in the 2-position via a lactam nucleus was studied. All these compounds exhibited a better effect than metronidazole and structure-activity relationships are discussed.
P Vanelle, P Timon-David, M P Crozet, O Jentzer, F Delmas, M Gasquet, J Maldonado   +6 more
core   +1 more source

New drugs against trypanosomatid parasites : rediscovery of fexinidazole [PDF]

, 2014
Neglected tropical diseases (NTDs) are a group of communicable diseases mostly affecting people in developing countries. These diseases are responsible for a major part of the global morbidity, mortality and poverty. There is no doubt that the well-being
Kaiser, Marcel
core   +1 more source

NITROIMIDAZOLES XI [I]. SYNTHESES OF DISUBSTITUTED NITROIMIDAZOLYLQUINOLINES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1995
Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-
doaj  

Tetrazine-based bioorthogonal reactions to image hypoxia in cancer cells

iScience
Summary: Suboptimal oxygen supply in solid tumors controls a variety of cancer hallmarks and impairs responsiveness to anticancer treatments. Yet, tools to visualize hypoxia in cancer are still limited.
Sara Boumya, Chiara Boero, Edoardo De Luigi, Federica Foglietta, Gustavo Ferreira-Alves, Daniele Mancardi, Barbara Lupo, Francesca Spyrakis, Loretta Lazzarato, Marta Serafini   +9 more
doaj   +1 more source

In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Objectives: Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. Pharmacodynamics studies included both in vitro and in
M. Van den Kerkhof, D. Mabille, E. Chatelain, C.E. Mowbray, S. Braillard, S. Hendrickx, L. Maes, G. Caljon   +7 more
doaj   +1 more source

Polarographic and electrochemical studies of some aromatic and heterocyclic nitro compounds, part IV: Polarographic reduction of 2‐alkylnitroimidazoles and aminonitroimidazoles

, 1992
1, 2‐Dialkyl‐4‐nitroimidazoles are reduced between pH 0 and 13 in a four‐electron wave. The resulting arylhydroxylamine is stable and in acidic media reduced further to the amine. 1,2‐Dialkyl‐5‐nitroimidazoles and 2‐alkyl‐4(5)‐nitroimidazoles are reduced
Zuman, P, D. Dumanović, J. Jovanović, D. Sužnjević, Erceg, M, Dumanović, D, M. Erceg, P. Zuman, Jovanović, J, Sužnjević, Desanka   +9 more
core   +1 more source

Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid

, 2017
A published study of structural features associated with the aerobic and anaerobic activities of 4- and 5-nitroimidazoles had found that the 3-nitro isomer of pretomanid, 8, displayed interesting potencies, including against nitroreductase-mutant ...
Scott G. Franzblau, George S. Wong, Franzblau, SG, Andrew M. Thompson, Christopher B. Cooper, Muriel Bonnet, Bonnet, M, Wan, B, Ho H. Lee, William A. Denny, Cooper, CB, Baojie Wan, Wong, GS, Lee, H, Denny, WA, Thompson, AM   +15 more
core   +1 more source

QT-Interval Prolongation in the Treatment of Drug-Resistant Tuberculosis

Антибиотики и Химиотерапия
The review analyzes the research articles, guidelines, and clinical trial results on the effect of fluoroquinolones, bedaquiline, nitroimidazoles, and clofazimine on QTc prolongation.
A. V. Kukurika
doaj   +1 more source

Medicinal Significance of Nitroimidazoles—Some Recent Advances

, 2003
659-665Nitroimidazoles have therapeutic uses as anaerobic anti bacterials and anti protozoal agents. Recently, they have been found to possess other interesting biological activities of therapeutic potential such as, radiosensitizers in treatment of ...
Chadha, Renu, Kapoor, V K, Venisetty, Praveen K, Prasanth, S   +3 more
core  

2-phenylindole-linked nitroimidazoles as potential radiosensitizers for estrogen receptor positive tumors

, 1990
5-Hydroxy-2-(4-hydroxyphenyl)-3-methylindole was linked to nitroimidazoles by tetramethylene and hexamethylene spacer groups. Derivatives with a C₆-spacer (4c and 4d) exhibited high binding affinities for the estrogen receptor (RBA = 3.5; estradiol: 100),
Angerer, Erwin von, Sebastian Erber, Erwin Von Angerer, Erber, Sebastian   +3 more
core   +1 more source