Results 81 to 90 of about 5,742 (217)
Molecules, 2016 We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz +4 more
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Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents
, 2014 International audience5-Nitroimidazoles are drugs having both antiprotozoal and antibacterial activity, but show mutagenicity and development of resistance observed particularly with metronidazole. For the development of new potentially safer derivatives,
Vanelle, Patrice +2 more
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NITROIMIDAZOLES VIII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-PYRIDYL-NITROIMIDAZOLES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1990 Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as ...
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Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole
, 2011 We have designed and synthesized econazole-derived nitroimidazoles to investigate the antitubercular activity of the nitroimidazole compounds. The introduction of a nitro group at the 4-position of the imidazole on econazole abolished the antitubercular ...
오태권, 조상래
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The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles
, 1987 The relationship between physicochemical parameters and biliary excretion of nitroimidazoles was investigated. The unmetabolized form of each drug was detected in the bile by means of a UV procedure.
GUERRA M.C. +5 more
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Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1998 The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
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, 2020 Antibiotic resistance has become a global crisis, driving the exploration for novel antibiotics and novel treatment approaches. Among these research efforts two classes of antibiotics, bicyclic nitroimidazoles and antimicrobial peptides, have recently ...
Popat, Amirali +3 more
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, 2012 The 5-nitroimidazole, metronidazole, has traditionally been employed in veterinary medicine to treat a range of infections including the diplomonad fish parasite Spironucleus.
Kolarich, D +18 more
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, 2017 1 pag. -- Open Access funded by Creative Commons Atribution Licence 3.0We present site selectivity studies by electron transfer induced dissociation experiments in potassium collisions with nitroimidazoles and methylnitroimidazoles. In this contribution
Ferreira da Silva, F. +7 more
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Molecules, 2013 Inhibitory activities of monocyclic nitroimidazoles against Mycobacterium tuberculosis (Mtb) deazaflavin-dependent nitroreductase (DDN) were modeled by using docking, pharmacophore alignment and comparative molecular similarity indices analysis (CoMSIA ...
Pyung Keun Myung +3 more
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