Results 81 to 90 of about 8,244 (233)

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Patent developments in antimycobacterial small-molecule therapeutics [PDF]

, 2005
At. present, clinical management of patients infected with Mycobacterium tuberculosis faces difficult problems, such as the worldwide emergence of multidrug resistant tuberculosis (MDR-TB), and the increase in AIDS-associated infections.
Van Calenbergh, Serge, Van Daele, Ineke
core   +2 more sources

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Neoteric advancement in TB drugs and an overview on the anti-tubercular role of peptides through computational approaches [PDF]

, 2017
Peptides of varied origins such as human immune cells and non-immune cells, bacteria, fungi, and venoms have been widely investigated as anti-tubercular agents for the replacement of existing anti-tubercular drugs in future.
Aarti, Chirom, Aarti, Chirom, BARBABOSA PLIEGO, ALBERTO, BARBABOSA PLIEGO, ALBERTO, KHUSRO, AMEER, KHUSRO, AMEER, Zeidan Mohamed Salem, Abdelfattah, Zeidan Mohamed Salem, Abdelfattah   +7 more
core  

Molecular dynamic simulation and inhibitor prediction of cysteine synthase structured model as a potential drug target for trichomoniasis [PDF]

, 2013
In our presented research, we made an attempt to predict the 3D model for cysteine synthase (A2GMG5-TRIVA) using homology-modeling approaches. To investigate deeper into the predicted structure, we further performed a molecular dynamics simulation for 10
Farmer, R, Gautam, B, Kumar, S, Sablok, G, Singh, AK, Singh, S   +5 more
core   +4 more sources

Molecular Mechanisms of Resistance and Treatment Efficacy of Delamanid Against Mycobacterium tuberculosis: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Tuberculosis (TB) remains a major global health problem, and treatment progress is increasingly threatened by rising multidrug‐resistant tuberculosis (MDR‐TB). Delamanid (DLM), a nitroimidazole drug, has shown good efficacy and safety against both drug‐susceptible and drug‐resistant Mycobacterium tuberculosis (Mtb) strains.
Md. Mahmudul Islam, Md. Zahid Hasan, Md. Touki Tahamid Tusar, Md. Yeamin Hossain, Md. Motaher Hossain, Md. Abdulla Al Jubayed, Md. Jubaer‐Al‐Abedin, Sheikh Soikot, Shanzida Akther, Jahid Bhuyian, Hafizur Rahman Gazi, B. M. Mahmudul Hasan, Md. Shofiul Azam, Md. Enamul Haque, Abdullah‐Al‐Jubayer, Md. Faruk Hasan, F. M. Ali Haydar, Md. Khalekuzzaman, Md. Torequl Islam, Sohel Hasan   +19 more
wiley   +1 more source

Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety

Molecules, 2016
We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz, Fanny Mathias, Alain Gamal Giuglio-Tonolo, Thierry Terme, Patrice Vanelle   +4 more
doaj   +1 more source

Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole [PDF]

, 2017
Objectives The characterization of Giardia lamblia WB C6 strains resistant to metronidazole and to the nitro-thiazole nitazoxanide [2-acetolyloxy-N-(5-nitro 2-thiazolyl) benzamide] as the parent compound of thiazolides, a novel class of anti-infective ...
Hemphill, Andrew, Müller, Joachim, Müller, Norbert, Sterk, Maaike   +3 more
core  

Optimum Treatment Regimens for Helicobacter Pylori Infection [PDF]

, 2000
The treatment of Helicobacter pylori infection includes of current standard triple therapies consisting of a proton pump inhibitor, clarithromycin and amoxicillin or metronidazole on the basis of simplicity, safety, and efficacy.
Hunt, R. H. (Richard)
core   +1 more source

Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review

Future Pharmacology
Neglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez, Edgar López-López, Catalina Soriano-Correa, Carolina Barrientos-Salcedo   +3 more
doaj   +1 more source