In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents
Memorias do Instituto Oswaldo CruzBACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10)
Ana Claudia Manoel Von Trompowsky +9 more
doaj +1 more source
Long-Term Antibiotic Treatment for Crohn's Disease: Systematic Review and Meta-Analysis of Placebo-Controlled Trials [PDF]
, 2017 Background. We investigated the effectiveness of long-term antibiotic treatment in patients with Crohn's disease. Methods. We performed a systematic review and meta-analysis of randomized clinical trials. Data sources were Medline (from 1966 through June
Egger, Matthias +5 more
core
Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. [PDF]
, 2019 BackgroundRapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs ...
Goldstein RE +6 more
core +1 more source
Two 1-substituted 4-nitroimidazoles
Acta Crystallographica Section C Crystal Structure Communications, 2001 Crystalline 4-nitro-1-phenylimidazole, C9H7N3O2, (I), and 4'-nitro-1-phenyl-4,1'-biiimidazole, C12H9N5O2, (II), contain C-H...O and C-H...N hydrogen bonds, connecting the molecules into infinite chains. The aromatic fragments in both compounds are nearly planar.
Kubicki, Maciej +3 more
openaire +3 more sources
Core Shell Investigation of 2-nitroimidazole [PDF]
Frontiers in Chemistry, 2019 Tunability and selectivity of synchrotron radiation have been used to study the excitation and ionization of 2-nitroimidazole at the C, N, and O K-edges. The combination of a set of different measurements (X-ray photoelectron spectroscopy, near-edge photoabsorption spectroscopy, Resonant Auger electron spectroscopy, and mass spectrometry) and ...
Paola Bolognesi +14 more
openaire +6 more sources
Activatable smart contrast agents for photoacoustic imaging
Smart Molecules, EarlyView.This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh +5 more
wiley +1 more source
Molecules, 2018 An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed and validated for confirmatory analysis of four nitroimidazoles and three hydroxy metabolites in honey. Honey samples were dissolved in
Xiaowei Li +7 more
doaj +1 more source
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis. [PDF]
PLoS ONE, 2014 PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during ...
Suresh B Lakshminarayana +14 more
doaj +1 more source
Genotoxicity profile of fexinidazole—a drug candidate in clinical development for human African trypanomiasis (sleeping sickness) [PDF]
, 2017 The parasitic disease human African trypanomiasis (HAT), also known as sleeping sickness, is a highly neglected fatal condition endemic in sub-Saharan Africa, which is poorly treated with medicines that are toxic, no longer effective or very difficult to
Bourdin Trunz, Bernadette +2 more
core
An epigenetic role for maternally inherited piRNAs in transposon silencing [PDF]
, 2008 In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic information.
Aravin, A. A. +5 more
core +2 more sources