Results 61 to 70 of about 4,252 (181)
NITROIMIDAZOLES VIII [I]. SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-PYRIDYL-NITROIMIDAZOLES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1990 Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as ...
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Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 1998 The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
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In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Objectives: Three new chemical series (bicyclic nitroimidazoles, aminopyrazoles and oxaboroles) were selected by Drugs for Neglected Diseases initiative as potential new drug leads for leishmaniasis. Pharmacodynamics studies included both in vitro and in
M. Van den Kerkhof +7 more
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MICROBIAL OXIDATION OF AMINOIMIDAZOLES TO NITROIMIDAZOLES
The Journal of Antibiotics, 1968 The structural requirements for the microbial transformation of 2-aminoimidazoles to 2-nitroimidazoles by Streptomyces strain LE/3342 have been investigated. Substrates carrying an alkyl group in position 4 (or 5) were oxidized, the efficiency decreasing with the increase of the length of the chain.
C C, Lancini, E, Lazzari, C, Sartori
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Molecules, 2013 Inhibitory activities of monocyclic nitroimidazoles against Mycobacterium tuberculosis (Mtb) deazaflavin-dependent nitroreductase (DDN) were modeled by using docking, pharmacophore alignment and comparative molecular similarity indices analysis (CoMSIA ...
Pyung Keun Myung +3 more
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NITROIMIDAZOLES XI [I]. SYNTHESES OF DISUBSTITUTED NITROIMIDAZOLYLQUINOLINES [PDF]
Journal of Sciences, Islamic Republic of Iran, 1995 Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-
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QT-Interval Prolongation in the Treatment of Drug-Resistant Tuberculosis
Антибиотики и ХимиотерапияThe review analyzes the research articles, guidelines, and clinical trial results on the effect of fluoroquinolones, bedaquiline, nitroimidazoles, and clofazimine on QTc prolongation.
A. V. Kukurika
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Green Processing and Synthesis, 2017 Green, sensitive and selective spectrophotometric methods were developed for the determination of nitrite in water samples. The methods (A, B and C) are based on the reduction of 5-nitroimidazoles; metronidazole (MTL), secnidazole (SCL) and tinidazole ...
Fraihat Safwan M.
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Nitroimidazole scaffold: a potential panacea for infectious diseases—a review
Discover ChemistryNitroimidazoles are five-membered heterocyclic ring systems in which the ‘’nitro’’ group is appended to either carbon 2 (benznidazole), 4 (pretomanid) or 5 (fexinidazole) of the imidazole ring.
Tshwanelo B. Matlala +3 more
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EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES.
Vitae, 2010 In this work we realized and experimental and theoretical study of the N-alkylation of nitroimidazoles.The N-alkyl-2-methyl-nitroimidazoles correspond to biologically active molecules, obtained by reactionof 2-methyl-5-nitroimidazole and different alkyl ...
Constain SALAMANCA M. +2 more
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