Results 41 to 50 of about 4,262 (181)

Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch, Daniela Hoedke, Marina Dourou, Elena Calciolari, David Herrera, Selena Toma   +5 more
wiley   +1 more source

In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents

Memorias do Instituto Oswaldo Cruz
BACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10)
Ana Claudia Manoel Von Trompowsky, Taline Ramos Conde, Renata Calil Lemos, Bruna Maria CS Quaresma, Marcelly Cristina SR Pitombeira, Alcione Silva de Carvalho, Núbia Boechat, Kelly Salomão, Solange Lisboa de Castro, Helena Pereira da Silva Zamith   +9 more
doaj   +1 more source

Autogenous Demineralized Dentin Graft–Based Strategies With or Without I‐PRF and Metronidazole for Ridge Preservation in Infected Sockets: A Randomized Clinical Trial

Journal of Periodontal Research, EarlyView.
This randomized controlled trial evaluated the efficacy of demineralized dentin graft (DDG) combined with injectable platelet‐rich fibrin (I‐PRF) and metronidazole (MTZ) versus DDG with or without I‐PRF in alveolar ridge preservation (ARP) of infected extraction sockets.
Mohamed Talaat Elbehwashy, Manal Mohamed Hosny, Ahmed Elfana, Heba Ahmed Saleh, Karim Fawzy El‐Sayed   +4 more
wiley   +1 more source

Confirmatory Analysis of Nitroimidazoles and Hydroxy Metabolites in Honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2018
An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed and validated for confirmatory analysis of four nitroimidazoles and three hydroxy metabolites in honey. Honey samples were dissolved in
Xiaowei Li, Yuebin Ke, Yingyu Wang, Chengfei Wang, Dongyang Ye, Xue Hu, Lan Zhou, Xi Xia   +7 more
doaj   +1 more source

Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis. [PDF]

PLoS ONE, 2014
PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during ...
Suresh B Lakshminarayana, Helena I M Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E Barry, Paul C Ho, Ujjini H Manjunatha   +14 more
doaj   +1 more source

Synthesis of New Active Sulfones in the 5-Nitroimidazole Series

Molecules, 2002
We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology.
Patrice Vanelle, Thierry Terme, Kamel Benakli   +2 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

ESTUDIO EXPERIMENTAL Y TEÓRICO DE LA SÍNTESIS DE N-ALQUIL-NITROIMIDAZOLES EXPERIMENTAL AND THEORETICAL STUDY OF SHYNTESIS OF N-ALKYL-NITROIMIDAZOLES.

Vitae, 2010
En este trabajo se realizó un estudio experimental y teórico sobre la N-alquilación de nitroimidazoles. Los N-alquil-2-metil-nitroimidazoles corresponden a moléculas con actividad biológica, que se obtienen por la reacción del 2-metil-5-nitroimidazol y ...
Constain SALAMANCA M, William TIZNADO V, Paula JARAMILLO G   +2 more
doaj