Results 41 to 50 of about 5,742 (217)
Pharmaceuticals, 2022 Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta +5 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão +12 more
wiley +1 more source
Nitroimidazoles for the treatment of TB: past, present and future
, 2011 Tuberculosis remains a leading cause of death resulting from an infectious agent, and the spread of multi- and extensively drug-resistant strains of Mycobacterium tuberculosis poses a threat to management of global health.
Tathagata Mukherjee, Helena Boshoff
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Common pathways and outliers in glucose catabolism across Trypanosomatidae
The FEBS Journal, EarlyView.Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes +5 more
wiley +1 more source
TLC–Densitometric Analysis of Selected 5-Nitroimidazoles
, 2023 Metronidazole, ornidazole, tinidazole, and secnidazole are 5-nitroimidazoles. The purpose of this work was to propose a new economical TLC–densitometric method to evaluate the chemical stability of metronidazole, secnidazole, ornidazole, and ...
Alina Pyka-Pająk
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Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review
Journal of Clinical Periodontology, EarlyView.ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch +5 more
wiley +1 more source
Synthesis of Optically Active Bicyclic Derivatives of Nitroimidazoles
, 2021 Nitroimidazoles are characterized by a wide range of biological activity and many of them are used as therapeutics. Moreover, some bicyclic nitroimidazooxazoles show considerable potency against Mycobacterium tuberculosis.
Lucjusz Zaprutko, Justyna Żwawiak
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Journal of Periodontal Research, EarlyView.This randomized controlled trial evaluated the efficacy of demineralized dentin graft (DDG) combined with injectable platelet‐rich fibrin (I‐PRF) and metronidazole (MTZ) versus DDG with or without I‐PRF in alveolar ridge preservation (ARP) of infected extraction sockets.
Mohamed Talaat Elbehwashy +4 more
wiley +1 more source
Refractory Giardiasis in an Immunosuppressed Patient in Turkey
Journal of Infection in Developing Countries, 2018 Giardiasis is an infection of the small intestine caused by the protozoan parasite Giardia duodenalis. In immunocompetent patients the infection is usually self-limited and no treatment may be needed.
Filiz Kaya +4 more
doaj +1 more source
, 1982 Chemical shifts of C-4 in series - a of 1 -substituted 5-nitroimidazoles fall within a narrow range of 130-133 ppm and those of C-5 in isomeric 4-nitro compounds (series-b) at 120-124 ppm, offering a method for distinguishing between isomeric pairs.
Parthasarathy, P. C. +4 more
core +1 more source