Results 51 to 60 of about 4,262 (181)

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Synthesis of New Potentially Bioactive Bicyclic 2-Pyridones

Molecules, 2005
Three convenient methods of reduction of the nitro group of 5-nitroimidazoles and 5-nitrothiazole that bear a diethylmethylene malonate group in an ortho-like position with respect to the nitro group and cyclization of the resulting amino derivatives are
Patrice Vanelle, Michel P. Crozet, Pascal George, Maxime D. Crozet   +3 more
doaj   +1 more source

Systemic Antibiotics in the Surgical Treatment of Peri‐Implantitis: Impact on the Salivary Microbiome

Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1265-1277, August 2026.
ABSTRACT Aim To exploratorily compare the shifts in the salivary microbiome composition after administration of two combined systemic antibiotic regimens used in the surgical treatment of peri‐implantitis. Materials and Methods A subset of 27 patients treated surgically for peri‐implantitis with an adjunctive 7‐day course of systemic antibiotics were ...
Caroline Riben Grundström, Bodil Lund, Nagihan Bostanci, Angelika Silbereisen, Alexandra Pennhag, Ina Schuppe Koistinen, Yinghua Zha, Anastasios Damdimopoulos, Georgios N. Belibasakis, Margareta Hultin   +9 more
wiley   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, Volume 13, Issue 40, 17 July 2026.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Effect of Chitosan‐Alginate Polyelectrolyte Complex Formation and Multilayer Polymer Configuration on the Characteristics of 3D‐Printed Metronidazole‐Loaded Periodontal Films

Biopolymers, Volume 117, Issue 4, July 2026.
The preparation and characterization of metronidazole loaded chitosan and alginate gels, followed by polyelectrolyte complex formation and 3D printing of multilayer periodontal films. ABSTRACT This study aimed to prepare six different metronidazole‐loaded film formulations by 3D printing for periodontal treatment.
Dicle Denizhan, Ayse Nur Buke, Muge Kilicarslan, Kaan Orhan, Hilal Basak Erol, Banu Kaskatepe   +5 more
wiley   +1 more source

Practical and Metal-Free Synthesis of Novel Enantiopure Amides Containing the Potentially Bioactive 5-Nitroimidazole Moiety

Molecules, 2016
We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H ...
Cédric Spitz, Fanny Mathias, Alain Gamal Giuglio-Tonolo, Thierry Terme, Patrice Vanelle   +4 more
doaj   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review

Future Pharmacology
Neglected tropical diseases (NTDs) are a significant global health problem. Additionally, anti-protozoan treatments are toxic, and their therapeutic regimens require prolonged treatment times and high concentrations of the drugs.
Micheel M. Vichi-Ramírez, Edgar López-López, Catalina Soriano-Correa, Carolina Barrientos-Salcedo   +3 more
doaj   +1 more source

Nitroimidazoles for imaging hypoxic myocardium

Journal of Nuclear Cardiology, 1995
A series of radiopharmaceuticals that incorporate nitroimidazole moieties have been synthesized to detect decreased local tissue pO2. In contrast to agents that localize in proportion to perfusion, these agents concentrate in hypoxic tissue. Myocardium with an intracellular pO2 < 3 mm Hg (about 25% of normal), which has lost its contractile ability but
H W, Strauss, A, Nunn, K, Linder
openaire   +2 more sources