Results 51 to 60 of about 5,742 (217)
In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents
Memorias do Instituto Oswaldo CruzBACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10)
Ana Claudia Manoel Von Trompowsky +9 more
doaj +1 more source
Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships
, 2009 Parasitic and bacterial infections affecting the gastrointestinal tract represent a significant cause of morbidity and mortality worldwide. Nitroheterocyclic drugs have been available since the early 1960s for the treatment of anaerobic protozoa.
Alka MITAL
core +1 more source
Synthesis of New Active Sulfones in the 5-Nitroimidazole Series
Molecules, 2002 We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology.
Patrice Vanelle +2 more
doaj +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Nitroimidazoles: Part XIX. Structure-activity relationships
, 1984 A variety of nitroimidazoles, mostly 1,2-disubstituted-5-nitroderivatives were examined for in vitro activity against E. histolytica and in early hepatic infection of infected golden hamsters. Many preparations carried a functionalised N atom at position
George, T. +6 more
core +1 more source
Scientific Reports, 2023 Infections by Entamoeba histolytica (E. histolytica) lead to considerable morbidity and mortality worldwide and treatment is reliant on a single class of drugs, nitroimidazoles.
Aradhana Singh +4 more
doaj +1 more source
Novel and emerging antimicrobial strategies in the management of oral infections
Periodontology 2000, EarlyView.Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley +1 more source
, 2016 Pd- or Ni-catalyzed C–H arylation of 4-nitroimidazole derivatives directed by a manipulable nitro group was developed. The reaction tolerates a wide range of substituted aryl halides and 4-nitroimidazoles.
Knar Arakelyan (1651669) +7 more
core +1 more source
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis. [PDF]
PLoS ONE, 2014 PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during ...
Suresh B Lakshminarayana +14 more
doaj +1 more source
Silent Contaminants: Antibiotic‐Resistant Bacteria in Food Systems
MicrobiologyOpen, Volume 15, Issue 6, December 2026.This graphical abstract illustrates the “farm‐to‐fork” cycle of antibiotic resistance, highlighting how antibiotic use promotes resistant bacteria that spread through animals, crops, food, and humans, emphasizing the interconnected nature of antimicrobial resistance and the need for integrated One Health strategies to mitigate its global impact ...
Răzvan Odocheanu +3 more
wiley +1 more source