Results 51 to 60 of about 8,244 (233)

Imaging tumour hypoxia with positron emission tomography. [PDF]

, 2014
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance.
A L Harris, AL Grosu, AM Jubb, B Gagel, B Gagel, B Gagel, BM Havelund, C Baldry, C West, CML Zegers, D Mönnich, D Rischin, D Thorwarth, D Thorwarth, DW Dietz, EJ Postema, F Dehdashti, F Dehdashti, F Dehdashti, F Hugonnet, F J Gilbert, GL Semenza, I N Fleming, I Shibahara, J Cheng, J Domarkas, J Overgaard, J Sato, J Yue, JA O’Donoghue, JD Chapman, JG Rajendran, JG Rajendran, JG Rajendran, JLJ Dearling, JS Lewis, JS Rasey, K J Williams, K Lehtiö, K Lehtiö, K Lehtiö, K Matsumoto, K Shi, K Tateishi, K Wang, KR Swanson, KSC Chao, L Bentzen, L Chen, L Dubois, L Li, L Vercellino, LM Cher, LS Mortensen, LS Mortensen, M Bruehlmeier, M Hu, M Höckel, M Kikuchi, M Schuetz, M Souvatzoglou, M Zimny, ME Trinkaus, MG Handley, MH Cherk, MJ Nyflot, MR Horsman, N Abolmaali, N Lee, N Takahashi, NY Lee, P Dirix, P J Blower, P McQuade, P Vaupel, P Vera, PE Valk, PW Grigsby, R Garcia–Parra, R Hueting, R Manavaki, RG Bristow, RJ Hicks, S Lord, S Okamoto, S Roels, S Thureau, SA Nehmeh, SM Eschmann, ST Lee, T Beppu, T Kaneta, T Segard, T Yamane, TG Lohith, VR Bollineni, WJ Koh, WR Wilson, X Geets, Y Minagawa   +99 more
core   +2 more sources

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. [PDF]

, 2016
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824).
Blaser, Adrian, Denny, William A, Franzblau, Scott G, Gupta, Suman, Launay, Delphine, Ma, Zhenkun, Maes, Louis, Martin, Denis, O'Connor, Patrick D, Thompson, Andrew M, Wan, Baojie, Wang, Yuehong, Yardley, Vanessa   +12 more
core   +3 more sources

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang   +9 more
wiley   +1 more source

Refractory Giardiasis in an Immunosuppressed Patient in Turkey

Journal of Infection in Developing Countries, 2018
Giardiasis is an infection of the small intestine caused by the protozoan parasite Giardia duodenalis. In immunocompetent patients the infection is usually self-limited and no treatment may be needed.
Filiz Kaya, Ahmet Çağkan İnkaya, Salih Maçin, Yakut Akyön, Sibel Ergüven   +4 more
doaj   +1 more source

Optimising hypoxia PET imaging and its applications in guiding targeted radiation therapy for non‐small cell lung cancer: a scoping review

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 106-118, March 2025.
This review article reports that quantification of hypoxic volumes using PET in the pre‐radiation therapy setting is of prognostic value and indicative of treatment response in non‐small cell lung cancer. Abstract Introduction Non‐small cell lung cancer (NSCLC) is the leading cause of cancer‐related death. Definitive treatment includes chemotherapy and
Carol Marks, Michelle Leech
wiley   +1 more source

Creep in nitroimidazole inhibitory concentration among the Entamoeba histolytica isolates causing amoebic liver abscess and screening of andrographolide as a repurposing drug

Scientific Reports, 2023
Infections by Entamoeba histolytica (E. histolytica) lead to considerable morbidity and mortality worldwide and treatment is reliant on a single class of drugs, nitroimidazoles.
Aradhana Singh, Tuhina Banerjee, Sunit Kumar Shukla, Soumya Upadhyay, Ashish Verma   +4 more
doaj   +1 more source

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity [PDF]

, 2019
Twenty nine original 3-nitroimidazo[1,2-a]pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized.
Azas, Nadine, Basmaciyan, Louise, Belle Mbou, Valère, Boudot, Clotilde, Bourgeade-Delmas, Sandra, Boutet-Robinet, Élisa, Casanova, Magali, Castera-Ducros, Caroline, Cohen, Anita, Courtioux, Bertrand, Fairlamb, Alan H., Fersing, Cyril, Hutter, Sébastien, Laget, Michèle, Milne, Rachel, Pedron, Julien, Piednoel, Mélanie, Primas, Nicolas, Rathelot, Pascal, Since, Marc, Sournia-Saquet, Alix, Valentin, Alexis, Vanelle, Patrice, Verhaeghe, Pierre, Wyllie, Susan   +24 more
core   +4 more sources

Nitroimidazoles for imaging hypoxic myocardium

Journal of Nuclear Cardiology, 1995
A series of radiopharmaceuticals that incorporate nitroimidazole moieties have been synthesized to detect decreased local tissue pO2. In contrast to agents that localize in proportion to perfusion, these agents concentrate in hypoxic tissue. Myocardium with an intracellular pO2 < 3 mm Hg (about 25% of normal), which has lost its contractile ability but
H W, Strauss, A, Nunn, K, Linder
openaire   +2 more sources

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source