Results 31 to 40 of about 8,244 (233)

Triple Therapy with High-Dose Proton-Pump Inhibitor, Amoxicillin, and Doxycycline Is Useless for Helicobacter pylori Eradication: A Proof-of-Concept Study [PDF]

, 2014
INTRODUCTION: Helicobacter pylori resistance to antibiotics is steadily increasing and multidrug-resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable. AIM:
Akyildiz, Alestig, Barza, Basu, Bayerdorffer, Boer, Borody, Cammarota, Chuah, Cianci, Clinical and Laboratory Standards Institute, Francesco, Francesco, Gerrits, Gisbert, Gisbert, Gisbert, Glocker, Glupczynski, Graham, Graham, Graham, Heep, Hulst, Inoue, Janssen, Kirchheiner, Koletzko, Kuo, Labenz, Loo, Malaty, Malfertheiner, Malfertheiner, McNicholl, Megraud, Megraud, Miehlke, Mégraud, Oleastro, Perri, Realdi, Rimbara, Sanches, Shirai, Taghavi, Tokoro, Usta, Villoria, Wang   +49 more
core   +1 more source

Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group

Memorias do Instituto Oswaldo Cruz, 2015
Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group.
Núbia Boechat, Alcione S Carvalho, Kelly Salomão, Solange L de Castro, Carlos F Araujo-Lima, Francisco VC Mello, Israel Felzenszwalb, Claudia AF Aiub, Taline Ramos Conde, Helena PS Zamith, Rolf Skupin, Günter Haufe   +11 more
doaj   +1 more source

Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection [PDF]

, 1998
In this randomized, multicenter trial, we evaluated the effectiveness and side effect profile of a modified omeprazole-based triple therapy to cure Helicobacter pylori infection.
Bayerdörffer, Ekkehard, Bolle, Karl-Heinz, Höchter, Wilhelm, Klann, Hermann, Krämer, Walter, Lehn, Norbert, Meining, Alexander, Miehlke, Stephan, Simon, Thomas, Sommer, Albrecht, Stolte, Manfred, Weingart, Josef   +11 more
core   +1 more source

Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode [PDF]

, 1997
The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed
Brett, Ana Maria Oliveira, Gutz, Ivano G. R., La-Scalea, Mauro A., Serrano, Sílvia H. P.   +3 more
core   +1 more source

Crystal structure of 1-methyl-2-[(E)-2-(4-methylphenyl)ethenyl]-4-nitro-1H-imidazole

Acta Crystallographica Section E, 2014
In the title molecule, C13H13N3O2, the planes of the benzene and imidazole rings form a dihedral angle of 7.72 (5)°. In the crystal, molecules are linked by weak C—H...N and C—H...O hydrogen bonds, forming layers parallel to (100).
Hayette Alliouche, Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Ali Belfaitah   +4 more
doaj   +1 more source

Therapeutic Failure and Acquired Bedaquiline and Delamanid Resistance in Treatment of Drug-Resistant TB

Emerging Infectious Diseases, 2023
New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance.
James Millard, Stephanie Rimmer, Camus Nimmo, Max O’Donnell   +3 more
doaj   +1 more source

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source

Synthesis of N-7-Substituted Purines from Imidazole Precursors

Molecules, 1999
Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj   +1 more source

2-Nitro-1-vinyl-1H-imidazole

Molbank, 2022
Nitroimidazoles are pharmacophoric groups responsible for important antiparasitic activity against several infectious diseases. 2-Nitroimidazoles are found in some antiparasitic drugs and are one of the main moieties responsible for the biological ...
Afonso Santine M. M. Velez, Gabriela Alves de Souza, Paulo Pitasse-Santos, Douglas Chaves de Alcântara Pinto, Debora Decote-Ricardo, Marco Edilson Freire de Lima   +5 more
doaj   +1 more source

Crystal structure of 2-{[1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yloxy]carbonyl}benzoic acid

Acta Crystallographica Section E, 2014
In the title compound, C15H15N3O6, the dihedral angle between the planes of the benzene and imidazole rings is 34.93 (10)°. An intramolecular C—H...O hydrogen bond is observed.
Hafiz Abdullah Shahid, Sajid Jahangir, Syed Adnan Ali Shah, Hamizah Mohd Zaki, Humera Naz   +4 more
doaj   +1 more source