Results 11 to 20 of about 4,262 (181)

Nitazoxanide and tizoxanide demonstrate high levels of in vitro activity against metronidazole-susceptible and metronidazole-resistant Trichomonas vaginalis clinical isolates [PDF]

Microbiology Spectrum
Trichomonas vaginalis is the most common non-viral sexually transmitted infection worldwide. We compared the in vitro activity of the thiazolide nitazoxanide (NTZ) and its metabolite, tizoxanide (TIZ), with the activity of the Food and Drug ...
Keonte J. Graves, John C. Williamson, Jan Novak, Hemant K. Tiwari, W. Evan Secor, Christina A. Muzny   +5 more
doaj   +2 more sources

Computational Studies on Recent Congeners of Fluoroquinolones and Nitroimidazoles for Their Use in Periodontal Therapy

Journal of Pharmacy and Bioallied Sciences
Background: Periodontitis is a slow progressing infection and has profound systemic implications. The influence of various therapeutic drugs to inhibit inflammation and promote bone regeneration has been studied.
Prabhu Manickam Natarajan
doaj   +2 more sources

Omeprazole as a Novel Treatment Option for Giardiasis in Cats [PDF]

Veterinary Medicine and Science
Background Giardiasis is a common protozoal infection in cats, often treated with nitroimidazole derivatives such as metronidazole and secnidazole. However, there are concerns about resistance to nitroimidazoles and their adverse effects. Recent in vitro
Murat Kaan Durgut, Mahmut Ok, Merve Ider, Amir Naseri, Suleyman Serhat Iyigun, Ayse Evci, Hatice Betul Sahin   +6 more
doaj   +2 more sources

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Tumor Hypoxia Imaging Agents in Nuclear Medicine

Trends in Peptide and Protein Sciences, 2017
Hypoxia is due to imbalance in oxygen supply and oxygen demand compromising biological functions of cells. Since tumor hypoxia results in angiogenesis, apoptosis, metastasis, tumor aggressiveness and treatment failure, in vivo measurement is required ...
Mahtab Mohammadpour, Soraya Shahhosseini
doaj   +1 more source

A reassessment of the role of oxygen scavenging enzymes in the emergence of metronidazole resistance in trichomonads

International Journal for Parasitology: Drugs and Drug Resistance, 2021
Trichomonads are an order of parasitic protists which infect a wide range of hosts. The human parasite Trichomonas vaginalis and the bovine parasite Tritrichomonas foetus which also infects cats and swine are of considerable medical and veterinary ...
Virág Gehl, Ana Paunkov, David Leitsch
doaj   +1 more source

^99mTc Labelling Strategies for the Development of Potential Nitroimidazolic Hypoxia Imaging Agents

Inorganics, 2019
Technetium-99m has a rich coordination chemistry that offers many possibilities in terms of oxidation states and donor atom sets. Modifications in the structure of the technetium complexes could be very useful for fine tuning the physicochemical and ...
Javier Giglio, Ana Rey
doaj   +1 more source

Clinical and Neuroradiological Spectrum of Metronidazole Induced Encephalopathy: Our Experience and the Review of Literature [PDF]

Journal of Clinical and Diagnostic Research, 2016
Metronidazole is an antimicrobial agent mainly used in the treatment of several protozoal and anaerobic infections, additionally, is often used in hepatic encephalopathy and Crohn disease.
Ujjawal Roy, Ajay Panwar, Alak Pandit, Susanta Kumar Das, Bhushan Joshi   +4 more
doaj   +1 more source

Some nitroimidazole derivatives as antibacterial and antifungal agents in in vitro study

Journal of Medical Science, 2019
Nitroimidazoles have wide range of therapeutic uses mainly as anaerobic antibacterials and antiprotozoal agents. Some bicyclic nitroimidazodihydrooxazoles and nitroimidazotetrahydrooxazines are found to be antituberculosis agents.
Justyna Żwawiak, Dorota Olender, Lucjusz Zaprutko   +2 more
doaj   +1 more source