Correlation between imaging and tissue biomarkers of hypoxia in squamous cell cancer of the head and neck [PDF]
World Journal of Nuclear Medicine, 2021 The aim of this study was to correlate endogenous tissue biomarkers of hypoxia with quantitative imaging parameters derived from 18F-fluoro-misonidazole (F-MISO) and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT)
Shreya Kunder +9 more
doaj +2 more sources
Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds [PDF]
Frontiers in Chemistry, 2019 Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Jacopo Chiarinelli +12 more
doaj +2 more sources
GSTP1 as a novel protective target in sepsis: evidence from proteome-wide Mendelian randomization and multi-omics analyses [PDF]
BMC Infectious DiseasesBackground Sepsis, a life-threatening inflammatory syndrome with incompletely understood genetic mechanisms, necessitates identification of pathogenic proteins to advance precision medicine.
Peng Peng +6 more
doaj +2 more sources
Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges. [PDF]
MedComm (2020)In this review, we first introduced the current application scenarios for radiotherapy in tumor treatment, the molecular mechanisms underlying anticancer effects of radiotherapy in treatment of cancer, and the side‐effects of radiotherapy. Second, we pay attention to discuss the main types of radiosensitizers and their latest applications and ...
Zhao Y +5 more
europepmc +2 more sources
MRI for biology-guided radiation therapy: Are we there yet? A summary of the 2024 ISMRM member-initiated session. [PDF]
Magn Reson MedAbstract At the 2024 ISMRM Annual Meeting in Singapore, a member‐initiated session on MRI for biology‐guided radiation therapy (RT), endorsed by the ISMRM MR in RT Study Group, was successfully organized. The session convened a diverse group of global experts in quantitative MRI for RT, who presented the latest research on the technical development and
Tadimalla S +12 more
europepmc +2 more sources
Low-Energy Electron-Induced Dissociation of the Radiosensitizing Agent Sanazole. [PDF]
ChempluschemEmploying mass spectrometry supported by quantum chemical calculations, electron attachment to gas‐phase and microhydrated sanazole, a hypoxic radiosensitizer, is examined. The results suggest that hydration closes and/or slows down the dissociation process and indicates that the initial mechanism of action in a reductive cell environment may be ...
Izadi F +5 more
europepmc +2 more sources
Ring Formation and Hydration Effects in Electron Attachment to Misonidazole [PDF]
International Journal of Molecular Sciences, 2019 Stephan Denifl +2 more
exaly +2 more sources
Results in Chemistry, 2022 A new series of 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazole derivatives 9a-j have been developed and synthesized. Further, the newly prepared compounds (9a-j) compounds were evaluated for their preliminary anticancer properties against four ...
Suresh Bairi +3 more
doaj +1 more source
Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons [PDF]
International Journal of Molecular Sciences, 2019 Stephan Denifl +2 more
exaly +2 more sources
Frontiers in Oncology, 2022 Glioblastomas (GBM) are the most common and aggressive form of primary malignant brain tumor in the adult population, and, despite modern therapies, patients often develop recurrent disease, and the disease remains incurable with median survival below 2 ...
Alessia Lodi +20 more
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