Results 1 to 10 of about 1,627 (175)

Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds [PDF]

Frontiers in Chemistry, 2019
Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Jacopo Chiarinelli, Jacopo Chiarinelli, Anna Rita Casavola, Mattea Carmen Castrovilli, Paola Bolognesi, Antonella Cartoni, Antonella Cartoni, Feng Wang, R. Richter, Daniele Catone, Sanja Tosic, Bratislav P. Marinkovic, Lorenzo Avaldi   +12 more
doaj   +4 more sources

Correlation between imaging and tissue biomarkers of hypoxia in squamous cell cancer of the head and neck [PDF]

World Journal of Nuclear Medicine, 2021
The aim of this study was to correlate endogenous tissue biomarkers of hypoxia with quantitative imaging parameters derived from 18F-fluoro-misonidazole (F-MISO) and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT)
Shreya Kunder, Abhishek Chatterjee, Subhakankha Manna, Manoj Mahimkar, Asawari Patil, Venkatesh Rangarajan, Ashwini Budrukkar, Sarbani Ghosh-Laskar, Jai Prakash Agarwal, Tejpal Gupta   +9 more
doaj   +2 more sources

GSTP1 as a novel protective target in sepsis: evidence from proteome-wide Mendelian randomization and multi-omics analyses [PDF]

BMC Infectious Diseases
Background Sepsis, a life-threatening inflammatory syndrome with incompletely understood genetic mechanisms, necessitates identification of pathogenic proteins to advance precision medicine.
Peng Peng, Xiudao Song, Jia Dan, Xuejiao Zhu, Xiaoxiao Zhang, Dan Xu, Hairui Liu   +6 more
doaj   +2 more sources

Targeting the Enhanced Sensitivity of Radiotherapy in Cancer: Mechanisms, Applications, and Challenges. [PDF]

MedComm (2020)
In this review, we first introduced the current application scenarios for radiotherapy in tumor treatment, the molecular mechanisms underlying anticancer effects of radiotherapy in treatment of cancer, and the side‐effects of radiotherapy. Second, we pay attention to discuss the main types of radiosensitizers and their latest applications and ...
Zhao Y, Tan F, Zhao J, Zhou S, Luo Y, Gong C.   +5 more
europepmc   +2 more sources

Low-Energy Electron-Induced Dissociation of the Radiosensitizing Agent Sanazole. [PDF]

Chempluschem
Employing mass spectrometry supported by quantum chemical calculations, electron attachment to gas‐phase and microhydrated sanazole, a hypoxic radiosensitizer, is examined. The results suggest that hydration closes and/or slows down the dissociation process and indicates that the initial mechanism of action in a reductive cell environment may be ...
Izadi F, Mahmoodi-Darian M, Luxford TFM, Kočišek J, Denifl S, Ončák M.   +5 more
europepmc   +2 more sources

Synthesis and biological evaluation of aryl 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazoles as anticancer agents

Results in Chemistry, 2022
A new series of 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazole derivatives 9a-j have been developed and synthesized. Further, the newly prepared compounds (9a-j) compounds were evaluated for their preliminary anticancer properties against four ...
Suresh Bairi, Veerachamy Alagarsamy, Shyam Sunder Rachamalla, Laxminarayana Eppakayala   +3 more
doaj   +1 more source

Circulating metabolites associated with tumor hypoxia and early response to treatment in bevacizumab-refractory glioblastoma after combined bevacizumab and evofosfamide

Frontiers in Oncology, 2022
Glioblastomas (GBM) are the most common and aggressive form of primary malignant brain tumor in the adult population, and, despite modern therapies, patients often develop recurrent disease, and the disease remains incurable with median survival below 2 ...
Alessia Lodi, Alessia Lodi, Renu Pandey, Renu Pandey, Jennifer Chiou, Jennifer Chiou, Ayon Bhattacharya, Shiliang Huang, Xingxin Pan, Brandon Burgman, Brandon Burgman, S. Stephen Yi, S. Stephen Yi, S. Stephen Yi, S. Stephen Yi, Stefano Tiziani, Stefano Tiziani, Stefano Tiziani, Stefano Tiziani, Stefano Tiziani, Andrew J. Brenner   +20 more
doaj   +1 more source

The pharmacological treatment of epilepsy in adults

Epileptic Disorders, Volume 25, Issue 5, Page 649-669, October 2023., 2023
Abstract The pharmacological treatment of epilepsy entails several critical decisions that need to be based on an individual careful risk–benefit analysis. These include when to initiate treatment and with which antiseizure medication (ASM). With more than 25 ASMs on the market, physicians have opportunities to tailor the treatment to individual ...
Torbjörn Tomson, Johan Zelano, Yew Li Dang, Piero Perucca   +3 more
wiley   +1 more source

Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Volume 4, Issue 1, February 2023., 2023
Solid tumors gradually form a hypoxic malignant microenvironment during growth, which promotes tumor proliferation and metastasis by affecting metabolism, angiogenesis, and immune escape, and finally leads to therapeutic resistance. In recent years, hypoxia‐inducible factor inhibitors, direct targeting of hypoxic cells, and respiratory hyperoxia have ...
Yan Zhuang, Kua Liu, Qinyu He, Xiaosong Gu, Chunping Jiang, Junhua Wu   +5 more
wiley   +1 more source

Ionization of 2‐ and 4(5)‐Nitroimidazoles Radiosensitizers: A “Kinetic Competition” Between NO2 and NO Losses

ChemPhysChem, Volume 22, Issue 23, Page 2387-2391, December 3, 2021., 2021
The kinetic competition between the NO and NO2 loss channels in 2‐Nitroimidazole ions favours the former channel at low energies (<12.76 eV). Thus, at these energies, 2‐Nitroimidazole is an exclusive NO source, unlike 4 and 5‐Nitroimidazole isomers.
Mauro Satta, Anna Rita Casavola, Antonella Cartoni, Mattea Carmen Castrovilli, Daniele Catone, Jacopo Chiarinelli, Stefano Borocci, Lorenzo Avaldi, Paola Bolognesi   +8 more
wiley   +1 more source