Results 1 to 10 of about 2,780 (171)
Correlation between imaging and tissue biomarkers of hypoxia in squamous cell cancer of the head and neck [PDF]
World Journal of Nuclear Medicine, 2021 The aim of this study was to correlate endogenous tissue biomarkers of hypoxia with quantitative imaging parameters derived from 18F-fluoro-misonidazole (F-MISO) and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT)
Shreya Kunder +9 more
doaj +2 more sources
Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies. [PDF]
PLoS ONE, 2017 PURPOSE:Mapping brain hypoxia is a major goal for stroke diagnosis, pathophysiology and treatment monitoring. 18F-fluoro-misonidazole (FMISO) positron emission tomography (PET) is the gold standard hypoxia imaging method.
Tim D Fryer +8 more
doaj +5 more sources
Radiation Damage Mechanisms of Chemotherapeutically Active Nitroimidazole Derived Compounds [PDF]
Frontiers in Chemistry, 2019 Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Jacopo Chiarinelli +12 more
doaj +2 more sources
GSTP1 as a novel protective target in sepsis: evidence from proteome-wide Mendelian randomization and multi-omics analyses [PDF]
BMC Infectious DiseasesBackground Sepsis, a life-threatening inflammatory syndrome with incompletely understood genetic mechanisms, necessitates identification of pathogenic proteins to advance precision medicine.
Peng Peng +6 more
doaj +2 more sources
Results in Chemistry, 2022 A new series of 1,2,4-oxadiazole incorporated (2-(oxazol)-1H-imidazole derivatives 9a-j have been developed and synthesized. Further, the newly prepared compounds (9a-j) compounds were evaluated for their preliminary anticancer properties against four ...
Suresh Bairi +3 more
doaj +1 more source
Frontiers in Oncology, 2022 Glioblastomas (GBM) are the most common and aggressive form of primary malignant brain tumor in the adult population, and, despite modern therapies, patients often develop recurrent disease, and the disease remains incurable with median survival below 2 ...
Alessia Lodi +20 more
doaj +1 more source
In vitro metabolism of misonidazole [PDF]
British Journal of Cancer, 1981 Misonidazole (MISO) is a nitroimidazole drug currently undergoing clinical trials as a radiosensitizer of hypoxic tumour cells. The drug is also toxic to such cells, probably because of metabolic activation of the nitro group under hypoxia. The metabolic fate of 14C-labelled MISO is examined, using hypoxic mammalian (CHO) cells in vitro.
P D, Josephy, B, Palcic, L D, Skarsgard
openaire +2 more sources
Bleomycin and misonidazole cytotoxicity [PDF]
British Journal of Cancer, 1985 Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and
M, Korbelik, B, Palcic, L D, Skarsgard
openaire +2 more sources
His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]
, 1988 The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M. +3 more
core +1 more source
SAGE Open Medicine, 2020 Introduction: In this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography. Methods: We conducted review of the current literature at PubMed/
Athanasios S Theodoropoulos +6 more
doaj +1 more source