Results 41 to 50 of about 1,627 (175)

In Vivo Evaluation of the Nitroimidazole‐Based Thioflavin‐T Derivatives as Cerebral Ischemia Markers

International Journal of Biomedical Imaging, Volume 2007, Issue 1, 2007., 2007
Timely imaging and accurate interpretation of cerebral ischemia are required to identify patients who might benefit from more aggressive therapy, and nuclear medicine offers a noninvasive method for demonstrating cerebral ischemia. Three nitroimidazole‐based thioflavin‐T derivatives, N‐[4‐(benzothiazol‐2‐yl)phenyl]‐3‐(4‐nitroimidazole‐1‐yl) propanamide
Taiwei Chu, Zejun Li, Xinqi Liu, Xiangyun Wang, Wei Liang   +4 more
wiley   +1 more source

The effect of hypobaric hypoxia on misonidazole binding in normal and tumour-bearing mice

, 1989
The effect of hypobaric hypoxia on the in vivo binding of misonidazole was investigated in normal mice and mice bearing T50/80 or CA NT mammary carcinomas. After the intraperitoneal injection of radiolabelled misonidazole, mice were randomised to breathe
Abram, W P, WP Abram, Maxwell, AP, MacManus, M P, MacManus, MP, Maxwell, A P; id_orcid, Bridges, JM, AP Maxwell, MP MacManus, JM Bridges, Abram, WP, Bridges, J M   +11 more
core   +1 more source

The role of misonidazole combined with intraoperative radiation therapy in the treatment of pancreatic carcinoma.

, 1987
We tested the efficacy of the hypoxic cell sensitizer misonidazole in conjunction with intraoperative electron beam radiation therapy (IORT) and external beam irradiation in patients with locally advanced, nonmetastatic adenocarcinoma of the pancreas ...
J E Tepper, A L Warshaw, E L Orlow, G L Nardi, W C Wood, W U Shipley   +5 more
core   +1 more source

Phase I trial of misonidazole (NSC#261037) plus cyclophosphamide in solid tumors.

, 1985
Misonidazole, a hypoxic cell sensitizer, enhances the antitumor effects of cyclophosphamide in preclinical studies. Several studies also showed increased cytotoxicity for normal tissues. We undertook a phase I study of this combination.
Vogel, C L, S Browning, Klein, L, Presant, C A, E Gorowski, Davila, E, Browning, S, Gorowski, E, R Johnson, Johnson, R, E Davila, Ostroy, F, R L Furner, F Ostroy, C A Presant, C L Vogel, Furner, R L, L Klein   +17 more
core   +1 more source

Effect of misonidazole on neurotransmitter systems

International Journal of Radiation Oncology*Biology*Physics, 1986
This study examines the effect of chronic administration of misonidazole on four neurotransmitter pathways (norepinephrine, dopamine, acetylcholine, and GABA) of the central nervous system (CNS). Biochemical assays examined the neurotransmitter synthesizing enzymes tyrosine hydroxylase (TOH) for catecholamines and choline acetyltransferase (CAT) for ...
T H, McNeill, L L, Koek, S A, Brown, R W, Hamill, J Y, Wu   +4 more
openaire   +2 more sources

A study of the effects of prior heat treatment on the skin reaction of mouse feet after heat alone or combined with X-rays: influence of misonidazole

, 1984
The skin of mouse feet was used to study the effects of hyperthermic treatment, either alone or combined with irradiation. The present experiments show that a priming heat treatment induces resistance both to a subsequent heat treatment and to a ...
Wondergem, J., Haveman, J.
core   +1 more source

Determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography with reductive electrochemical detection

, 1984
A reversed-phase high-performance liquid chromatographic method with reductive mode electrochemical detection was developed for the determination of misonidazole and desmethylmisonidazole in plasma.
Maes, R.A.A., Zijp, J.J., R.A. Baumann, Meering, P.G., R.A.A. Maes, Baumann, R.A., J.J. Zijp, P.G. Meering   +7 more
core   +1 more source

Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group trial.

, 1993
PURPOSE Long-term follow-up data of a randomized trial that compared hydroxyurea and the hypoxic-cell radiosensitizer to misonidazole as adjuncts to standard radiation therapy in locally advanced carcinoma of the cervix are reported. PATIENTS AND METHODS
W T Creasman, W C Fowler, G Thomas, B N Bundy, G d'Ablaing, F B Stehman, R Mortel, H M Keys   +7 more
core   +1 more source

18F-Misonidazole PET-CT scan detection of occult bone metastasis

, 2016
A 67-year-old man with locally advanced non-small cell lung cancer entered a phase I trial combining a novel phosphoinositide 3-kinase inhibitor (BKM120) with palliative radiotherapy.1 The trial uses 18F-misonidazole (FMISO) positron emission tomography (
Higgins, Geoff S., Fenwick, John D., McGowan, Daniel R., Gleeson, Fergus V., Macpherson, Ruth E., Bradley, Kevin M.   +5 more
core   +1 more source

Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model [PDF]

, 2004
Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor ...
Schneede, Peter, Lein, Michael, Bise, Karl, Zaak, Dirk, Baumgartner, Reinhold, Stocker, Susanne, Höppner, Michael, Kriegmair, Martin, Knüchel, Ruth, Hofstetter, Alfons, Frimberger, Dominic, Sroka, Ronald, Reich, Oliver   +12 more
core   +1 more source