Results 31 to 40 of about 1,627 (175)

Stroma Targeting Nuclear Imaging and Radiopharmaceuticals

International Journal of Molecular Imaging, Volume 2012, Issue 1, 2012., 2012
Malignant transformation of tumor accompanies profound changes in the normal neighboring tissue, called tumor stroma. The tumor stroma provides an environment favoring local tumor growth, invasion, and metastatic spreading. Nuclear imaging (PET/SPECT) measures biochemical and physiologic functions in the human body.
Dinesh Shetty, Jae-Min Jeong, Hyunsuk Shim, Izabela Tworowska   +3 more
wiley   +1 more source

Misonidazole Neuropathy:a clinical, electrophysiological, and histological study

, 1982
We studied eight patients with carcinoma of the pharynx and larynx (five cases) or lungs (three cases) who, during treatment with the radiosensitizing drug misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs ...
Tang, X, Paulson, O B, Kamieniecka, Z, Trojaborg, Werner, Pedersen, A G, Melgaard, B, Hansen, H S   +6 more
core   +1 more source

Integrating Imaging Data into Predictive Biomathematical and Biophysical Models of Cancer

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
While there is a mature literature on biomathematical and biophysical modeling in cancer, many of the existing approaches are not of clinical utility, as they require input data that are extremely difficult to obtain in an intact organism, and/or require a large number of assumptions on the free parameters included in the models.
Thomas E. Yankeelov, J. Chow, S.-C. Ngan, J. Suehnel   +3 more
wiley   +1 more source

Enhancement of melphalan-induced tumour cell killing by misonidazole: An interaction of competing mechanisms [PDF]

, 1984
In the present studies we have used the RIF-1 tumour in C3H mice to try to identify the mechanism(s) responsible for the enhancement of melphalan (L-PAM) induced tumour cell killing by the 2-nitroimidazole misonidazole (MISO).
M R Horsman, Horsman, MR, Evans, JW, J W Evans, Brown, JM, J M Brown   +5 more
core   +1 more source

Hypoxia in Head and Neck Squamous Cell Carcinoma

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
Hypoxia is a common feature in most of the solid tumors including head and neck squamous cell carcinoma (HNSCC). Hypoxia reflects the imbalance between oxygen consumption by the rapidly proliferating cancer cells and the insufficient oxygen delivery due to poor vascularization and blood supply.
John Zenghong Li, Wei Gao, Jimmy Yu-Wai Chan, Wai-Kuen Ho, Thian-Sze Wong, M. V. Nestor, M. B. Paiva   +6 more
wiley   +1 more source

Binding of the hypoxia tracer [3H]misonidazole in cerebral ischemia.

, 1987
Radiolabelled misonidazole, a radiosensitizing drug that binds to viable hypoxic tumor cells, may be useful in identifying hypoxic cells in cerebrovascular disease. Its potential was investigated in the gerbil stroke model.
K A Krohn, J M Hoffman, D W Shaw, J S Rasey, A M Spence   +4 more
core   +1 more source

Synthesis and In Vitro Antibacterial Activity of New 2‐(1‐Methyl‐4‐nitro‐1H‐imidazol‐5‐ylsulfonyl)‐1,3,4‐thiadiazoles

Journal of Chemistry, Volume 8, Issue 3, Page 1120-1123, 2011., 2011
In the present study we report the synthesis and antibacterial activity of a new series 2‐(1‐methyl‐4‐nitro‐1H‐imidazol‐5‐ylsulfonyl)‐1,3,4‐thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram‐negative and gram‐positive bacteria.
Bahram Letafat, Negar Mohammadhosseini, Ali Asadipour, Alireza Foroumadi   +3 more
wiley   +1 more source

Design of silicon-based misonidazole analogues and (18)F-radiolabelling.

, 2009
International audienceINTRODUCTION: Development of new (18)F-labeled tracers for positron emission tomography (PET) imaging is increasingly important.
Bischoff, Laurent, Azzouz, Rabah, Fiol-Petit, Catherine, Fruit, Corinne, Marsais, Francis, Bohn, Pierre, Vera, Pierre, Deyine, Abdallah, Bailly, Laetitia   +8 more
core   +1 more source

Neon ion (20Ne10+) charged particle beams manipulate rapid tumor reoxygenation in syngeneic mouse models

Cancer Science, Volume 115, Issue 1, Page 227-236, January 2024.
Quantitative non‐hypoxic (Splatoon) maps of the tumors tested. The Splatoon maps indicate accelerated tumor reoxygenation in the tumors irradiated with neon ions. Abstract Charged particle beams induce various biological effects by creating high‐density ionization through the deposition of energy along the beam's trajectory.
Akiko Imaizumi, Ryoichi Hirayama, Yoko Ikoma, Nobuhiro Nitta, Takayuki Obata, Sumitaka Hasegawa   +5 more
wiley   +1 more source

Recent Advances in Image‐Guided Radiotherapy for Head and Neck Carcinoma

Journal of Oncology, Volume 2009, Issue 1, 2009., 2009
Radiotherapy has a well‐established role in the management of head and neck cancers. Over the past decade, a variety of new imaging modalities have been incorporated into the radiotherapy planning and delivery process. These technologies are collectively referred to as image‐guided radiotherapy and may lead to significant gains in tumor control and ...
Sameer K. Nath, Daniel R. Simpson, Brent S. Rose, Ajay P. Sandhu, Paul Harari   +4 more
wiley   +1 more source