Results 11 to 20 of about 1,229 (138)
The pharmacological treatment of epilepsy in adults
Epileptic Disorders, Volume 25, Issue 5, Page 649-669, October 2023., 2023 Abstract The pharmacological treatment of epilepsy entails several critical decisions that need to be based on an individual careful risk–benefit analysis. These include when to initiate treatment and with which antiseizure medication (ASM). With more than 25 ASMs on the market, physicians have opportunities to tailor the treatment to individual ...
Torbjörn Tomson +3 more
wiley +1 more source
Hypoxia signaling in cancer: Implications for therapeutic interventions
MedComm, Volume 4, Issue 1, February 2023., 2023 Solid tumors gradually form a hypoxic malignant microenvironment during growth, which promotes tumor proliferation and metastasis by affecting metabolism, angiogenesis, and immune escape, and finally leads to therapeutic resistance. In recent years, hypoxia‐inducible factor inhibitors, direct targeting of hypoxic cells, and respiratory hyperoxia have ...
Yan Zhuang +5 more
wiley +1 more source
Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies. [PDF]
PLoS ONE, 2017 PURPOSE:Mapping brain hypoxia is a major goal for stroke diagnosis, pathophysiology and treatment monitoring. 18F-fluoro-misonidazole (FMISO) positron emission tomography (PET) is the gold standard hypoxia imaging method.
Tim D Fryer +8 more
doaj +1 more source
ChemPhysChem, Volume 22, Issue 23, Page 2387-2391, December 3, 2021., 2021 The kinetic competition between the NO and NO2 loss channels in 2‐Nitroimidazole ions favours the former channel at low energies (<12.76 eV). Thus, at these energies, 2‐Nitroimidazole is an exclusive NO source, unlike 4 and 5‐Nitroimidazole isomers.
Mauro Satta +8 more
wiley +1 more source
In vitro metabolism of misonidazole [PDF]
British Journal of Cancer, 1981 Misonidazole (MISO) is a nitroimidazole drug currently undergoing clinical trials as a radiosensitizer of hypoxic tumour cells. The drug is also toxic to such cells, probably because of metabolic activation of the nitro group under hypoxia. The metabolic fate of 14C-labelled MISO is examined, using hypoxic mammalian (CHO) cells in vitro.
P D, Josephy, B, Palcic, L D, Skarsgard
openaire +2 more sources
A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy
Advanced Science, Volume 8, Issue 7, April 7, 2021., 2021 Tumor‐specific ultrasound‐activated oxygen microbubbles are developed to sensitize hypoxic tumor cells for 125I brachytherapy. The microbubbles, lyophilized for storage and easily reconstituted in situ before administration, have much better stability by the addition of sulfur hexafluoride into oxygen.
Sheng Peng +10 more
wiley +1 more source
Bleomycin and misonidazole cytotoxicity [PDF]
British Journal of Cancer, 1985 Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and
M, Korbelik, B, Palcic, L D, Skarsgard
openaire +2 more sources
TARGETING OF TUMOR CELLS BY LIPOSOMES – ENCAPSULATED MISONIDAZOL
Zagazig Journal of Pharmaceutical Sciences, 1998 The effect of liposomal drug encapsulation on the distribution pattern of the encapsulated drug, in tumor and normal tissues of tumor-bearing mouse, was studied.
Samir Abu-Zaid
doaj +1 more source
SAGE Open Medicine, 2020 Introduction: In this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography. Methods: We conducted review of the current literature at PubMed/
Athanasios S Theodoropoulos +6 more
doaj +1 more source
Molecules, 2013 In this work, a sensitive analytical method to study the stability of two new series of synthesized heterocyclic compounds, the benzimidazole-4,7-diones 5 and N-oxide benzimidazole-4,7-dione derivatives 6 was established and validated. These derivatives
Katarzyna Błaszczak-Świątkiewicz +3 more
doaj +1 more source