Results 11 to 20 of about 1,627 (175)
Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies. [PDF]
PLoS ONE, 2017 PURPOSE:Mapping brain hypoxia is a major goal for stroke diagnosis, pathophysiology and treatment monitoring. 18F-fluoro-misonidazole (FMISO) positron emission tomography (PET) is the gold standard hypoxia imaging method.
Tim D Fryer +8 more
doaj +3 more sources
Bleomycin and misonidazole cytotoxicity [PDF]
British Journal of Cancer, 1985 Chinese hamster ovary (CHO) cells were exposed in vitro to combinations of bleomycin and misonidazole under hypoxic conditions. Only one drug was present at any given time and cells were washed before being exposed to the second drug. Both drugs induced potentially lethal damage (PLD). This damage was repaired under hypoxic conditions very rapidly, and
M, Korbelik, B, Palcic, L D, Skarsgard
openaire +3 more sources
In vitro metabolism of misonidazole [PDF]
British Journal of Cancer, 1981 Misonidazole (MISO) is a nitroimidazole drug currently undergoing clinical trials as a radiosensitizer of hypoxic tumour cells. The drug is also toxic to such cells, probably because of metabolic activation of the nitro group under hypoxia. The metabolic fate of 14C-labelled MISO is examined, using hypoxic mammalian (CHO) cells in vitro.
P D, Josephy, B, Palcic, L D, Skarsgard
openaire +3 more sources
Ring Formation and Hydration Effects in Electron Attachment to Misonidazole. [PDF]
Int J Mol Sci, 2019 This research was funded by CZECH SCIENCE FOUNDATION grant number 19-01159S; Czech Ministry of Education Youth and Sports via OP RDE Grant no. CZ.02.2.69/0.0/16_027/0008355; S.D.
Ončák M +8 more
europepmc +2 more sources
A Robust Oxygen Microbubble Radiosensitizer for Iodine‐125 Brachytherapy
Advanced Science, Volume 8, Issue 7, April 7, 2021., 2021 Tumor‐specific ultrasound‐activated oxygen microbubbles are developed to sensitize hypoxic tumor cells for 125I brachytherapy. The microbubbles, lyophilized for storage and easily reconstituted in situ before administration, have much better stability by the addition of sulfur hexafluoride into oxygen.
Sheng Peng +10 more
wiley +1 more source
Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0-10 eV) Electrons. [PDF]
Int J Mol Sci, 2019 Misonidazole (MISO) was considered as radiosensitizer for the treatment of hypoxic tumors. A prerequisite for entering a hypoxic cell is reduction of the drug, which may occur in the early physical-chemical stage of radiation damage.
Meißner R +3 more
europepmc +2 more sources
TARGETING OF TUMOR CELLS BY LIPOSOMES – ENCAPSULATED MISONIDAZOL
Zagazig Journal of Pharmaceutical Sciences, 1998 The effect of liposomal drug encapsulation on the distribution pattern of the encapsulated drug, in tumor and normal tissues of tumor-bearing mouse, was studied.
Samir Abu-Zaid
doaj +1 more source
SAGE Open Medicine, 2020 Introduction: In this study, we evaluated the use and the contribution of radiopharmaceuticals to the field of lung neoplasms imaging using positron emission tomography/computed tomography. Methods: We conducted review of the current literature at PubMed/
Athanasios S Theodoropoulos +6 more
doaj +1 more source
Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer
Advanced Science, Volume 7, Issue 24, December 16, 2020., 2020 Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies including in deep tissue. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways ...
Sandhya Clement +7 more
wiley +1 more source