Results 21 to 30 of about 1,229 (138)
Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer
Advanced Science, Volume 7, Issue 24, December 16, 2020., 2020 Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies including in deep tissue. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways ...
Sandhya Clement +7 more
wiley +1 more source
Radiation Oncology, 2018 Background To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeoxyglucose PET/CT (FDG-PET ...
Nicole Wiedenmann +16 more
doaj +1 more source
Oxygen dependence for chemosensitization by misonidazole [PDF]
British Journal of Cancer, 1986 Misonidazole (MISO) potentiates the cell killing effect of certain chemotherapy agents, but only under hypoxic conditions. The purpose of the present study was to define the range of oxygen concentrations over which chemosensitization by MISO takes place using mammalian cells cultured in vitro, and to compare this with the oxygen levels required for ...
L, Roizin-Towle, E J, Hall, J P, Pirro
openaire +2 more sources
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
Clinical and Translational Medicine, Volume 8, Issue 1, December 2019., 2019 AbstractPancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune cells including cytotoxic T cells; however, there is an overall immunosuppressive milieu.
S. K. Daniel +3 more
wiley +1 more source
Journal of Chemistry, Volume 2019, Issue 1, 2019., 2019 Enaminone, (2E)‐1‐[4‐(1H‐imidazol‐1‐yl) phenyl]‐4‐methylpent‐2‐en‐1‐one (II) was synthesized by refluxing 1‐[4‐(1H‐imidazol‐1‐yl) phenyl] ethan‐1‐one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent‐free condition for 12 hours. Finally, the dihydropyrimidinone derivatives containing imidazole moiety (1–15) were obtained by reacting ...
Mashooq Ahmad Bhat +5 more
wiley +1 more source
Preclinical Molecular Imaging for Precision Medicine in Breast Cancer Mouse Models
Contrast Media &Molecular Imaging, Volume 2019, Issue 1, 2019., 2019 Precision and personalized medicine is gaining importance in modern clinical medicine, as it aims to improve diagnostic precision and to reduce consequent therapeutic failures. In this regard, prior to use in human trials, animal models can help evaluate novel imaging approaches and therapeutic strategies and can help discover new biomarkers.
M. F. Fiordelisi +8 more
wiley +1 more source
Molecular Oncology, Volume 10, Issue 5, Page 704-718, May 2016., 2016 Background: Rationalization of antiangiogenics requires biomarkers. Vascular re‐normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with 18F‐misonidazole ([18F]‐FMISO, a probe that detects hypoxia) PET, in response to ...
Elena Hernández-Agudo +10 more
wiley +1 more source
Microenvironment and Radiation Therapy
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor hypoxia. The first approach to overcome tumor hypoxia was to improve tumor oxygenation by increasing oxygen delivery and a subsequent approach was the use of radiosensitizers in combination with ...
Michio Yoshimura +4 more
wiley +1 more source
Stroma Targeting Nuclear Imaging and Radiopharmaceuticals
International Journal of Molecular Imaging, Volume 2012, Issue 1, 2012., 2012 Malignant transformation of tumor accompanies profound changes in the normal neighboring tissue, called tumor stroma. The tumor stroma provides an environment favoring local tumor growth, invasion, and metastatic spreading. Nuclear imaging (PET/SPECT) measures biochemical and physiologic functions in the human body.
Dinesh Shetty +3 more
wiley +1 more source
Integrating Imaging Data into Predictive Biomathematical and Biophysical Models of Cancer
International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012 While there is a mature literature on biomathematical and biophysical modeling in cancer, many of the existing approaches are not of clinical utility, as they require input data that are extremely difficult to obtain in an intact organism, and/or require a large number of assumptions on the free parameters included in the models.
Thomas E. Yankeelov +3 more
wiley +1 more source