Results 21 to 30 of about 1,627 (175)

Synthesis, Anticancer Activity and UPLC Analysis of the Stability of Some New Benzimidazole-4,7-dione Derivatives

Molecules, 2013
In this work, a sensitive analytical method to study the stability of two new series of synthesized heterocyclic compounds, the benzimidazole-4,7-diones 5 and N-oxide benzimidazole-4,7-dione derivatives 6 was established and validated. These derivatives
Katarzyna Błaszczak-Świątkiewicz, Diogo Correia Almeida, Maria De Jesus Perry, Elżbieta Mikiciuk-Olasik   +3 more
doaj   +1 more source

Effect of radiochemotherapy on T2* MRI in HNSCC and its relation to FMISO PET derived hypoxia and FDG PET

Radiation Oncology, 2018
Background To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeoxyglucose PET/CT (FDG-PET ...
Nicole Wiedenmann, Hatice Bunea, Hans C. Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H. Nicolay, Wolfgang A. Weber, Michael Mix, Philipp T. Meyer, Jürgen Hennig, Michael Bock, Anca L. Grosu   +16 more
doaj   +1 more source

Oxygen dependence for chemosensitization by misonidazole [PDF]

British Journal of Cancer, 1986
Misonidazole (MISO) potentiates the cell killing effect of certain chemotherapy agents, but only under hypoxic conditions. The purpose of the present study was to define the range of oxygen concentrations over which chemosensitization by MISO takes place using mammalian cells cultured in vitro, and to compare this with the oxygen levels required for ...
L, Roizin-Towle, E J, Hall, J P, Pirro
openaire   +2 more sources

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma

Clinical and Translational Medicine, Volume 8, Issue 1, December 2019., 2019
AbstractPancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune cells including cytotoxic T cells; however, there is an overall immunosuppressive milieu.
S. K. Daniel, K. M. Sullivan, K. P. Labadie, V. G. Pillarisetty   +3 more
wiley   +1 more source

Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety

Journal of Chemistry, Volume 2019, Issue 1, 2019., 2019
Enaminone, (2E)‐1‐[4‐(1H‐imidazol‐1‐yl) phenyl]‐4‐methylpent‐2‐en‐1‐one (II) was synthesized by refluxing 1‐[4‐(1H‐imidazol‐1‐yl) phenyl] ethan‐1‐one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent‐free condition for 12 hours. Finally, the dihydropyrimidinone derivatives containing imidazole moiety (1–15) were obtained by reacting ...
Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Atef Kalmouch, Abdullah Al-Dhfyan, Mohamed Afzal Pasha   +5 more
wiley   +1 more source

Preclinical Molecular Imaging for Precision Medicine in Breast Cancer Mouse Models

Contrast Media &Molecular Imaging, Volume 2019, Issue 1, 2019., 2019
Precision and personalized medicine is gaining importance in modern clinical medicine, as it aims to improve diagnostic precision and to reduce consequent therapeutic failures. In this regard, prior to use in human trials, animal models can help evaluate novel imaging approaches and therapeutic strategies and can help discover new biomarkers.
M. F. Fiordelisi, L. Auletta, L. Meomartino, L. Basso, G. Fatone, M. Salvatore, M. Mancini, A. Greco, Luděk Šefc   +8 more
wiley   +1 more source

Monitoring vascular normalization induced by antiangiogenic treatment with 18F‐fluoromisonidazole‐PET

Molecular Oncology, Volume 10, Issue 5, Page 704-718, May 2016., 2016
Background: Rationalization of antiangiogenics requires biomarkers. Vascular re‐normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with 18F‐misonidazole ([18F]‐FMISO, a probe that detects hypoxia) PET, in response to ...
Elena Hernández-Agudo, Tamara Mondejar, Maria Luisa Soto-Montenegro, Diego Megías, Silvana Mouron, Jesus Sanchez, Manuel Hidalgo, Pedro Pablo Lopez-Casas, Francisca Mulero, Manuel Desco, Miguel Quintela-Fandino   +10 more
wiley   +1 more source

Induced Hypoxia in Rat Pulp and Periapex Demonstrated by 3H-Misonidazole Retention [PDF]

, 1996
Cellular hypoxia may be a useful indication of tissue distress in the dental pulp that could be used to investigate the early stages of pulpal responses. Tritiated misonidazole (3H-MISO) is a marker which preferentially labels cells with decreased oxygen
Walton, R. E., Baumgardner, K. R., Osborne, J. W., Born, J. L.   +3 more
core   +1 more source

Microenvironment and Radiation Therapy

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor hypoxia. The first approach to overcome tumor hypoxia was to improve tumor oxygenation by increasing oxygen delivery and a subsequent approach was the use of radiosensitizers in combination with ...
Michio Yoshimura, Satoshi Itasaka, Hiroshi Harada, Masahiro Hiraoka, Juan Carlos Calvo   +4 more
wiley   +1 more source

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy. [PDF]

, 2010
Oral cavity and oropharyngeal cancers are frequently described as part of a group of oral cancers or head and neck cancer. Treatment of oral cavity cancer is generally surgery followed by radiotherapy, whereas oropharyngeal cancers, which are more likely
Clarkson, Jan E.; id_orcid, null The CSROC Expert Panel, Furness, Susan, Glenny, A.M., Oliver, R., Jan E Clarkson, Macluskey, Michaelina; id_orcid, Furness, S, Glenny, Anne-Marie, Macluskey, M., Clarkson, Jan E., The CSROC Expert Panel, CSROC Expert Panel, Chan, Kelvin K.W., Chan, K.K.W., Conway, DI, Clarkson, Jan E, Conway, David I., Glenny, AM, Clarkson, JE, Kelvin KW Chan, Pavitt, S., Worthington, Helen V, CSROC Expert Panel, [Unknown], Michaelina Macluskey, Furness, S., Worthington, Helen V., The CSROC Expert Panel,, Chan, Kelvin K. W., Pavitt, S, Chan, Kelvin KW, Anne-Marie Glenny, Oliver, R, Glenny, Anne Marie; id_orcid, David I Conway, Conway, D.I., Macluskey, Michaelina, Worthington, HV; id_orcid, Clarkson, J.E., Pavitt, Sue, Chan, KK, Worthington, HV, Macluskey, M, Worthington, Helen V.; id_orcid, Richard Oliver, Oliver, Richard, Helen V Worthington, Susan Furness, Sue Pavitt, Paul Brocklehurst, Worthington, H.V., Brocklehurst, Paul, Brocklehurst, P   +52 more
core   +1 more source