Results 21 to 30 of about 2,799 (186)

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Advanced Science, Volume 7, Issue 24, December 16, 2020., 2020
Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies including in deep tissue. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways ...
Sandhya Clement, Jared M. Campbell, Wei Deng, Anna Guller, Saadia Nisar, Guozhen Liu, Brian C. Wilson, Ewa M. Goldys   +7 more
wiley   +1 more source

Effect of radiochemotherapy on T2* MRI in HNSCC and its relation to FMISO PET derived hypoxia and FDG PET

Radiation Oncology, 2018
Background To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeoxyglucose PET/CT (FDG-PET ...
Nicole Wiedenmann, Hatice Bunea, Hans C. Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H. Nicolay, Wolfgang A. Weber, Michael Mix, Philipp T. Meyer, Jürgen Hennig, Michael Bock, Anca L. Grosu   +16 more
doaj   +1 more source

Tumor hypoxia and reoxygenation: the yin and yang for radiotherapy. [PDF]

, 2016
Tumor hypoxia, a common feature occurring in nearly all human solid tumors is a major contributing factor for failures of anticancer therapies. Because ionizing radiation depends heavily on the presence of molecular oxygen to produce cytotoxic effect ...
Beom Ju Hong, G One Ahn, Hoibin Jeong, Jeongwoo Kim, Seoyeon Bok, Young Eun Kim   +5 more
core   +1 more source

Oxygen dependence for chemosensitization by misonidazole [PDF]

British Journal of Cancer, 1986
Misonidazole (MISO) potentiates the cell killing effect of certain chemotherapy agents, but only under hypoxic conditions. The purpose of the present study was to define the range of oxygen concentrations over which chemosensitization by MISO takes place using mammalian cells cultured in vitro, and to compare this with the oxygen levels required for ...
L, Roizin-Towle, E J, Hall, J P, Pirro
openaire   +2 more sources

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K., Barendsen G.W, Barendsen G.W., Borek C., Burch P.R.J., Elkind M.M., Hall E.J., Han A., Han A., Hill C.K., Hill C.K., Hill C.K., Lloyd E.L., Miller R.C., Miller R.C., Reznikoff C., Robertson J.B., Roos H., Rossi H.H., Terzaghi M., Yang T.   +20 more
core   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Radiosensitizers in cervical cancer. Cisplatin and beyond [PDF]

, 2006
Cervical cancer continues to be a significant health burden worldwide. Globally, the majority of cancers are locally advanced at diagnosis; hence, radiation remains the most frequently used therapeutical modality. Currently, the value of adding cisplatin
Candelaria Myrna, Cetina Lucely, Dueñas-Gonzalez Alfonso, Garcia-Arias Alicia   +3 more
core   +3 more sources

Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model [PDF]

, 2004
Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor ...
Baumgartner, Reinhold, Bise, Karl, Frimberger, Dominic, Hofstetter, Alfons, Höppner, Michael, Knüchel, Ruth, Kriegmair, Martin, Lein, Michael, Reich, Oliver, Schneede, Peter, Sroka, Ronald, Stocker, Susanne, Zaak, Dirk   +12 more
core   +1 more source

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma

Clinical and Translational Medicine, Volume 8, Issue 1, December 2019., 2019
AbstractPancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune cells including cytotoxic T cells; however, there is an overall immunosuppressive milieu.
S. K. Daniel, K. M. Sullivan, K. P. Labadie, V. G. Pillarisetty   +3 more
wiley   +1 more source

Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement [PDF]

, 2015
Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide.
Cuestas, María Luján, Mathet, Veronica Lidia, Oubiña, Jose Raul   +2 more
core   +1 more source