Results 51 to 60 of about 1,627 (175)
Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole
, 1994 The synthesis of a nido-carboranyl congener of misonidazole, 1-(3′-nido-carboranyl-2′-hydroxy)propyl-2-nitroimidazole, has been carried out. Alternative methods of preparations were conducted to optimize the chemical yield, with a five step synthesis ...
Livesey, John C. +5 more
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Influence of manipulating hypoxia in solid tumors on the radiation dose-rate effect in vivo, with reference to that in the quiescent cell population. [PDF]
, 2010 PURPOSE: The aim of this study was to clarify the effect of manipulating intratumor hypoxia on radiosensitivity under reduced dose-rate (RDR) irradiation. MATERIALS AND METHODS: Tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to
Shin-ichiro Masunaga +23 more
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Chemical and biological studies of the radiosensitizer misonidazole
, 1981 Misonidazole (Ro 07-0582) is a nitroheterocyclic drug which sensitizes hypoxic (oxygen-deficient) cells to the lethal action of ionising radiation. Tumours contain radioresistant hypoxic cells which may limit the usefulness of radiotherapy as a modality ...
Josephy, P. David
core
Misonidazole with small dose fractions in an experimental osteosarcoma
, 1978 Chemicals/CAS: misonidazole, 13551-87-6; Nitroimidazoles; Radiation-Sensitizing ...
Putten, L.M. van, Smink, T.
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Splanchnic tissues undergo hypoxic stress during whole body hyperthermia
, 1999 Exposure of conscious animals to environmental heat stress increases portal venous radical content. The nature of the observed heat stress-inducible radical molecules suggests that hyperthermia produces cellular hypoxic stress in liver and intestine.
David M. Hall +3 more
core +1 more source
, 2009 To report the results from a prospective study of a series of locoregionally advanced head-and-neck cancer patients treated with platinum-based chemotherapy and intensity-modulated radiotherapy and to discuss the findings of their pre-/mid-treatment [18F]
Kelvin Chan +13 more
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Misonidazole binding in murine liver tissue: a marker for cellular hypoxia in vivo
, 1989 The hepatic microcirculation is believed to cause variable cellular oxygenation within the organ. In this study a marker of cellular hypoxia was used to demonstrate liver oxygen tension gradients in vivo.
Gardiner, T. A. +2 more
core
, 2019 Photoionization mass spectrometry, photoelectron-photoion coincidence spectroscopic technique, and computational methods have been combined to investigate the fragmentation of two nitroimidazole derived compounds: the metronidazole and misonidazole ...
Bratislav P. Marinkovic (6533702) +10 more
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The Therapeutic Potential of Imidazole or Quinone-Based Compounds as Radiosensitisers in Combination with Radiotherapy for the Treatment of Head and Neck Squamous Cell Carcinoma. [PDF]
Cancers (Basel), 2022 Azad A, Kong A.
europepmc +1 more source
, 1994 The radiosensitizing effect of AK-2123, a 3-nitrotriazole, and of misonidazole, a 2-nitroimidazole, was studied on hypoxically irradiated Chinese hamster cells (V79-379A) with DNA damage as end-point.
Imamura, M, Edgren, M
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