Results 21 to 30 of about 4,252 (181)
Journal of Global Antimicrobial Resistance, 2022 : Objectives: This study aimed to evaluate the antibiotic prescription patterns of health workers in Eastern Uganda and more specifically whether they are in accordance with the Ugandan standard treatment guidelines and other indicators of appropriate ...
Samuel Baker Obakiro +8 more
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Journal of Chemistry, 2018 A novel method for the rapid separation and determination of five polar 5-nitroimidazoles in water from different sources by pressurized capillary electrochromatography has been developed.
Sulan Liao, Qilin Weng
doaj +1 more source
Recent Developments in PET and SPECT Radiotracers as Radiopharmaceuticals for Hypoxia Tumors
Pharmaceutics, 2023 Hypoxia, a deficiency in the levels of oxygen, is a common feature of most solid tumors and induces many characteristics of cancer. Hypoxia is associated with metastases and strong resistance to radio- and chemotherapy, and can decrease the accuracy of ...
Anh Thu Nguyen, Hee-Kwon Kim
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Memorias do Instituto Oswaldo Cruz, 2015 Nitroimidazoles exhibit high microbicidal activity, but mutagenic, genotoxic and cytotoxic properties have been attributed to the presence of the nitro group.
Núbia Boechat +11 more
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Crystal structure of 1-methyl-2-[(E)-2-(4-methylphenyl)ethenyl]-4-nitro-1H-imidazole
Acta Crystallographica Section E, 2014 In the title molecule, C13H13N3O2, the planes of the benzene and imidazole rings form a dihedral angle of 7.72 (5)°. In the crystal, molecules are linked by weak C—H...N and C—H...O hydrogen bonds, forming layers parallel to (100).
Hayette Alliouche +4 more
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Molbank, 2022 Nitroimidazoles are pharmacophoric groups responsible for important antiparasitic activity against several infectious diseases. 2-Nitroimidazoles are found in some antiparasitic drugs and are one of the main moieties responsible for the biological ...
Afonso Santine M. M. Velez +5 more
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Synthesis of N-7-Substituted Purines from Imidazole Precursors
Molecules, 1999 Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
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Emerging Infectious Diseases, 2023 New classes of antitubercular drugs, diarylquinolines and nitroimidazoles, have been associated with improved outcomes in the treatment of drug-resistant tuberculosis, but that success is threatened by emerging drug resistance.
James Millard +3 more
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Crystal structure of 2-{[1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yloxy]carbonyl}benzoic acid
Acta Crystallographica Section E, 2014 In the title compound, C15H15N3O6, the dihedral angle between the planes of the benzene and imidazole rings is 34.93 (10)°. An intramolecular C—H...O hydrogen bond is observed.
Hafiz Abdullah Shahid +4 more
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Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins
Redox Biology, 2021 Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts.
Faisal Bin Rashed +13 more
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