Results 21 to 30 of about 5,742 (217)

Tumor Hypoxia Imaging Agents in Nuclear Medicine

open access: yesTrends in Peptide and Protein Sciences, 2017
Hypoxia is due to imbalance in oxygen supply and oxygen demand compromising biological functions of cells. Since tumor hypoxia results in angiogenesis, apoptosis, metastasis, tumor aggressiveness and treatment failure, in vivo measurement is required ...
Mahtab Mohammadpour, Soraya Shahhosseini
doaj   +1 more source

A reassessment of the role of oxygen scavenging enzymes in the emergence of metronidazole resistance in trichomonads

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance, 2021
Trichomonads are an order of parasitic protists which infect a wide range of hosts. The human parasite Trichomonas vaginalis and the bovine parasite Tritrichomonas foetus which also infects cats and swine are of considerable medical and veterinary ...
Virág Gehl, Ana Paunkov, David Leitsch
doaj   +1 more source

Clinical and Neuroradiological Spectrum of Metronidazole Induced Encephalopathy: Our Experience and the Review of Literature [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
Metronidazole is an antimicrobial agent mainly used in the treatment of several protozoal and anaerobic infections, additionally, is often used in hepatic encephalopathy and Crohn disease.
Ujjawal Roy   +4 more
doaj   +1 more source

Some nitroimidazole derivatives as antibacterial and antifungal agents in in vitro study

open access: yesJournal of Medical Science, 2019
Nitroimidazoles have wide range of therapeutic uses mainly as anaerobic antibacterials and antiprotozoal agents. Some bicyclic nitroimidazodihydrooxazoles and nitroimidazotetrahydrooxazines are found to be antituberculosis agents.
Justyna Żwawiak   +2 more
doaj   +1 more source

Are antibiotic prescription practices in Eastern Uganda concordant with the national standard treatment guidelines? A cross-sectional retrospective study

open access: yesJournal of Global Antimicrobial Resistance, 2022
: Objectives: This study aimed to evaluate the antibiotic prescription patterns of health workers in Eastern Uganda and more specifically whether they are in accordance with the Ugandan standard treatment guidelines and other indicators of appropriate ...
Samuel Baker Obakiro   +8 more
doaj   +1 more source

Recent Developments in PET and SPECT Radiotracers as Radiopharmaceuticals for Hypoxia Tumors

open access: yesPharmaceutics, 2023
Hypoxia, a deficiency in the levels of oxygen, is a common feature of most solid tumors and induces many characteristics of cancer. Hypoxia is associated with metastases and strong resistance to radio- and chemotherapy, and can decrease the accuracy of ...
Anh Thu Nguyen, Hee-Kwon Kim
doaj   +1 more source

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

open access: yes, 2016
The 4-nitroimidazole PA-824 is active against aerobic and anaerobic Mycobacterium tuberculosis (Mtb) while 5-nitroimidazoles like metronidazole are active against only anaerobic Mtb.
Pilho Kim (2387116)   +9 more
core   +1 more source

Ionization of 2‐ and 4(5)‐Nitroimidazoles Radiosensitizers: A “Kinetic Competition” Between NO(2) and NO Losses [PDF]

open access: yes, 2021
Nitroimidazoles are a class of chemicals with a remarkable broad spectrum of applications from the production of explosives to the use as radiosensitizers in radiotherapy.
Catone, Daniele   +17 more
core   +1 more source

Improved syntheses of n-substituted nitroimidazoles

open access: yes, 1989
Nitroimidazoles are of considerable medical and potential agricultural interest as chemotherapeutic agents and potential biocides. The standard route to many 1-substituted nitroimidazoles is the condensation of the conjugate base of the nitroimidazole in
Lee, J. B., Pye, P. L., Searcey, M.
core   +1 more source

Crystal structure of 1-methyl-2-[(E)-2-(4-methylphenyl)ethenyl]-4-nitro-1H-imidazole

open access: yesActa Crystallographica Section E, 2014
In the title molecule, C13H13N3O2, the planes of the benzene and imidazole rings form a dihedral angle of 7.72 (5)°. In the crystal, molecules are linked by weak C—H...N and C—H...O hydrogen bonds, forming layers parallel to (100).
Hayette Alliouche   +4 more
doaj   +1 more source

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