Results 171 to 180 of about 5,742 (217)
Some of the next articles are maybe not open access.
Tinidazole: A nitroimidazole antiprotozoal agent
Clinical Therapeutics, 2005Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
openaire +2 more sources
Clinical experience with nitroimidazoles as radiosensitizers
International Journal of Radiation Oncology*Biology*Physics, 1982Abstract Clinical experience at Mount Vernon now includes 248 patients who have been given misonidazole (Ro 07–0582) and 57 patients who have been given desmethylmisonidazole (Ro 05–9963). Work with Ro 03–8799 is now beginning. The promise of chemical agents to improve the results of the radiotherapy is dependent upon effective levels of ...
S, Dische +4 more
openaire +2 more sources
The synthesis of azomycin (2-Nitroimidazole)
Experientia, 1965La sintesi del 2-nitroimidazolo e del 1-metil-2-nitroimidazolo per diazotasione e reasione di Gattermann a partire dai corrispondenti 2-aminoimidasoli dimostra che, in determinate condizioni, questi ultimi si comportano come composti a carattere aromatico.
G C, LANCINI, E, LAZZARI
openaire +2 more sources
Pharmacokinetics of Nitroimidazoles
1982In this paper I want to try and show how a knowledge of the metabolism and pharmacokinetics of a compound helps us to understand the reasons why it may or may not satisfy the criteria desired of a particular drug. How we want a drug to behave depends on the use we have in mind for it. For example, in Fig.
T. R. Marten +3 more
openaire +1 more source
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics
International Journal of Radiation Oncology*Biology*Physics, 1984We have studied the effect of a number of nitroimidazole sensitizers of varying lipophilicity on the pharmacokinetics of CCNU in mice. It was found that the effectiveness of these compounds in producing pharmacokinetic effects correlated directly with their lipophilicity, viz.
F Y, Lee, P, Workman
openaire +2 more sources
Acta Crystallographica Section C Crystal Structure Communications, 1996
X-ray analysis confirmed the configuration of the title N1-alkylated C4-nitroimidazole inhibitor. The plane of the imidazole ring, sitting on an axis of the trityl propeller, bisects the angle between two phenyl rings, while the nitro group extends over the third.
E, Skrzypczak-Jankun, R G, Kurumbail
openaire +2 more sources
X-ray analysis confirmed the configuration of the title N1-alkylated C4-nitroimidazole inhibitor. The plane of the imidazole ring, sitting on an axis of the trityl propeller, bisects the angle between two phenyl rings, while the nitro group extends over the third.
E, Skrzypczak-Jankun, R G, Kurumbail
openaire +2 more sources
Radiosensitization of solid tumors by nitroimidazoles
International Journal of Radiation Oncology*Biology*Physics, 1978Abstract Recently a new class of drugs has been identified by Adams et al. at the Gray Laboratory, which act as specific radiosensitizers of hypoxic cells. This sensitization results from their high electron affinity, and their presence at the time of irradiation abolishes the protection afforded by hypoxia.
J, Denekamp, J F, Fowler
openaire +2 more sources
Nitroimidazole-induced chronic hepatitis
European Journal of Gastroenterology & Hepatology, 2001Drug-induced chronic hepatitis is a rare pathological condition. There is no reported case with chronic hepatitis secondary to nitroimidazole use. We report a patient who developed nitroimidazole-induced chronic hepatitis following acute exacerbation of hepatitis three times after nitroimidazole use.
Ersoz, G +5 more
openaire +3 more sources
Synthesis, Thermal Hazard Analysis and Density Functional Theory Study of Nitroimidazoles
Thermochimica Acta, 2022Juncheng Jiang, Peng Ma, Lina Hao
exaly