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The mutagenic action of nitroimidazoles II. Effects of 2-nitroimidazoles
Mutation Research/Environmental Mutagenesis and Related Subjects, 1975The 2-nitroimidazoles Ro-71051 (N-benzyl-2-nitro-1-imidazole-acetamide) and Ro-5-9963 (3(2-nitro-1-imidazolyl)-1,2-propanediol) increased the mutation rate of a Klebsiella pneumoniae mutant to streptomycin-resistance including streptomycin-dependence in Luria and Delbruck's fluctuation test in concentrations of 0.05-1 mM and 0.02-0.2 mM respectively ...
C E, Voogd +2 more
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Nitroimidazoles and imaging hypoxia
European Journal of Nuclear Medicine, 1995Decreased tissue oxygen tension is a component of many diseases. Although hypoxia can be secondary to a low inspired pO2 or a variety of lung disorders, the commonest cause is ischemia due to an oxygen demand greater than the local oxygen supply. In tumors, low tissue pO2 is often observed, most often due to a blood supply inadequate to meet the tumor ...
A, Nunn, K, Linder, H W, Strauss
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Modification of chemotherapy by nitroimidazoles
International Journal of Radiation Oncology*Biology*Physics, 1984The potentiation of chemotherapeutic agents by radiation sensitizers has been extensively studied for several years. There is little doubt that the effectiveness of certain anti-cancer drugs, primarily alkylating agents, can readily be enhanced both in vitro and in vivo through the addition of a sensitizer.
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Nitroimidazoles as chemotherapeutic agents
1983During the last two decades, or, more precisely, ever since the introduction of metronidazole into therapy, nitroimidazoles as a class of compounds have attracted much attention. Nevertheless, no adequate review of this chemical class has appeared in literature, even though a large number of reviews on the chemotherapy of protozoal diseases refer to ...
M D, Nair, K, Nagarajan
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1982
The development in recent years of nitroimidazoles as chemotherapeutic agents has been extensive. The interest in this class of compounds apparently was raised in 1955 by the elucidation of the structure of the antibiotic Azomycin by Nakamura(l) and the discovery of the in vivo activity of 5-nitro-imidazoles against Trichomonas vaginalis(2). Since then
D. E. Schwartz, W. Hofheinz
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The development in recent years of nitroimidazoles as chemotherapeutic agents has been extensive. The interest in this class of compounds apparently was raised in 1955 by the elucidation of the structure of the antibiotic Azomycin by Nakamura(l) and the discovery of the in vivo activity of 5-nitro-imidazoles against Trichomonas vaginalis(2). Since then
D. E. Schwartz, W. Hofheinz
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Chemistry & Biodiversity, 2006
AbstractA series of 5‐alkylamino and 5‐alkylsulfanyl derivatives of 1‐aryl‐2‐alkyl‐4‐nitro‐1H‐imidazoles 12–21, 31, and 34 were synthesized by a simple method with the aim to develop novel HIV non‐nucleoside reverse transcriptase inhibitors (NNRTIs). All the new compounds were tested against HIV‐1 and HIV‐2 in MT‐4 cells.
Najim A, Al-Masoudi +4 more
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AbstractA series of 5‐alkylamino and 5‐alkylsulfanyl derivatives of 1‐aryl‐2‐alkyl‐4‐nitro‐1H‐imidazoles 12–21, 31, and 34 were synthesized by a simple method with the aim to develop novel HIV non‐nucleoside reverse transcriptase inhibitors (NNRTIs). All the new compounds were tested against HIV‐1 and HIV‐2 in MT‐4 cells.
Najim A, Al-Masoudi +4 more
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Permeability of Nitroimidazoles in Rat Cortex
Chemotherapy, 2009The right cerebral hemisphere of the rat was perfused in situ by retrograde bolus infusion of some nitroimidazole drugs into the external carotid artery. The right jugular vein served to collect blood samples. Drugs were continuously measured in the right cortex by microvoltametric electrodes and in blood samples by high-performance liquid ...
A, Meulemans +4 more
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Electrochemical behaviour of 4-nitroimidazole and 2-methyl-5-nitroimidazole
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1982Abstract The electrochemical behaviour of the title imidazoles (HRNO 2 ) has been investigated in dimethylformamide and acetonitrile by polarography, cyclic voltammetry and controlled-potential electrolysis and coulometry. The above nitroimidazoles present similar behaviour, displaying two reduction waves paralleled by two reduction peaks in linear ...
S. Roffia, C. Gottardi, E. Vianello
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Pharmacokinetics and Pharmacodynamics of the Nitroimidazole Antimicrobials
Clinical Pharmacokinetics, 1999Metronidazole, the prototype nitroimidazole antimicrobial, was originally introduced to treat Trichomonas vaginalis, but is now used for the treatment of anaerobic and protozoal infections. The nitroimidazoles are bactericidal through toxic metabolites which cause DNA strand breakage.
K C, Lamp +3 more
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Studies on the action of nitroimidazole drugs. The products of nitroimidazole reduction.
Biochemical pharmacology, 1983The electron requirements for the electrolytic reduction of misonidazole, metronidazole and 4(5)-nitroimidazole have been measured using high-resolution coulometry. Eleven of the labelled final reduction products of metronidazole (a 5-nitroimidazole) have been separated by high-performance liquid chromatography and identified. These appear to be formed
R J, Knox, R C, Knight, D I, Edwards
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