Results 51 to 60 of about 33,505 (218)

Effect of Dexamethasone in Mediating Oxidative Stress Induced by Sodium Nitroprusside on Frog Sciatic Nerve Action Potentials

Bezmiâlem Science, 2013
Objective:High concentrations of nitric oxide cause a neurotoxic effect on nerve action potentials. Although glucocorticoids can decrease that effect, the degree of mediation is not known. This study determined the effect of dexamethasone on frog sciatic
Ugur AKSU, Pinar ATUKEREN, Duygu TERZIOGLU, Ahmet BELCE, Cihan DEMIRCI-TANSEL   +4 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Does sodium nitroprusside kill babies? A systematic review

São Paulo Medical Journal, 2007
OBJECTIVE: To determine whether sodium nitroprusside causes fetal death in pregnancies complicated with hypertension. DATA SOURCES: Medical Literature Analysis and Retrieval System Online (MEDLINE; 1996 to 2003), Excerpta Medica (EMBASE; 1970 to 2003 ...
Nelson Sass, Caroline Harumi Itamoto, Marina Pereira Silva, Maria Regina Torloni, Álvaro Nagib Atallah   +4 more
doaj   +1 more source

THE TOXICITY OF SODIUM NITROPRUSSIDE

British Journal of Anaesthesia, 1974
Four of 8 baboons given sodium nitroprusside in a study of induced hypotension failed to recover normal arterial pressure after discontinuance of i.v. infusion; instead arterial pressure continued to decrease progressively and irreversibly. Other features noted in these animals were metabolic acidosis in both arterial blood and cerebrospinal fluid, and
D G, McDowall, N P, Keaney, J M, Turner, J R, Lane, Y, Okuda   +4 more
openaire   +2 more sources

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Sodium nitroprusside has leishmanicidal activity independent of iNOS

Revista da Sociedade Brasileira de Medicina Tropical, 2016
: INTRODUCTION: Leishmaniasis is a zoonotic disease caused by protozoa of the genus Leishmania . Cutaneous leishmaniasis is the most common form, with millions of new cases worldwide each year.
Natália Yoshie Kawakami, Fernanda Tomiotto-Pellissier, Allan Henrique Depieri Cataneo, Tatiane Marcusso Orsini, Ana Paula Fortes Dos Santos Thomazelli, Carolina Panis, Ivete Conchon-Costa, Wander Rogério Pavanelli   +7 more
doaj   +1 more source

Nitroprusside and the Treatment of Hypertension [PDF]

Congestive Heart Failure, 2011
…2. Intravenously injected nitroprusside is strongly hypotensive without producing tachyphylaxis. Adrenergic blocking agents and surgical ablation of portions of the central nervous system failed to abolish its action…. Dogs with experimental neurogenic hypertension are more sensitive than renal hypertensive or normotensive dogs to the depressor effect
openaire   +2 more sources

Multi‐Subunit Engineering of Photorespiratory Glycine Decarboxylase Refines Photosynthesis, Growth and Metabolic Robustness of Arabidopsis

Plant, Cell &Environment, EarlyView.
ABSTRACT Photorespiration secures oxygenic photosynthesis from metabolic constraints arising from the oxygenation reaction of Rubisco in today's oxygen‐rich atmosphere. Beyond this protective function, it is vital for primary metabolism, cellular redox balance, and stomatal regulation.
Hu Sun, Yannic C. R. Wagner, Wieke‐Marie Rosenfeldt, Rhena Schumann, Stéphanie Arrivault, Guillaume Decros, Rhiannon Page, Elizabete Carmo Silva, Tracy Lawson, Wei Huang, Alisdair R. Fernie, Hermann Bauwe, Martin Hagemann, Stefan Timm   +13 more
wiley   +1 more source

Postharvest treatments to reduce chilling injury in summer squash (Cucurbita pepo) fruits during storage

The Indian Journal of Agricultural Sciences, 2019
The present study was carried out to minimize postharvest problems of chilling injury during cold storage by the application of anti-chilling compounds, viz. salicylic acid (SA), sodium nitroprusside (SNP) and a nitric oxide donor (NO).
PANKAJ KUMAR KANNAUJIA, RAM ASREY, AWANI KUMAR SINGH, ELDHO VARGHESE   +3 more
doaj   +1 more source

VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption

Experimental Physiology, EarlyView.
Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz   +3 more
wiley   +1 more source