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Genotoxicity of nitrosated ranitidine
Mutation Research Letters, 1989The genotoxicity of ranitidine, widely used in the therapy of peptic ulcers, and of nitrosated ranitidine was examined in test systems with the bacteria Salmonella typhimurium for gene mutations, and with the yeast Saccharomyces cerevisiae D7 for reverse mutations and gene conversion.
Franekić, Jasna +2 more
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Genotoxicity of nitrosated ranitidine
Carcinogenesis, 1983The in vitro reaction of nitrite with the histamine H2-receptor antagonist ranitidine, in acidified solutions or in human gastric juice, resulted in the formation of genotoxic derivatives, mainly eliciting base-pair substitutions in his-Salmonella typhimurium and trp- Escherichia coli and inducing an increased lethality in DNA repair-deficient bacteria.
S, De Flora +3 more
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Mutagenicity of nitrosated cimetidines
Carcinogenesis, 1981Dinitrosocimetidine and mononitrosocimetidine were tested in a series of short term assay systems. Both compounds were mutagenic in the absence of rat liver microsomes. The dinitrosocimetidine produced higher mutagenic or clastogenic effects at concentrations that were 50 to 500 times lower than the concentrations at which the mononitrosocimetidine ...
D, Ichinotsubo +4 more
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Detection of Nitrosated Proteins
Current Protocols in Toxicology, 1999AbstractThree methods are provided in this unit to detect nitrosated proteins. The Saville assay is the most commonly used and has the advantages that it is less sensitive to interference than the quinine sulfate‐based fluorescent assay, uses simple chemical reagents, and requires a spectrophotometer. The diaminonaphthalene assay (a fluorescence assay)
Y Y, Zhang, J, Loscalzo
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Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil
Organic & Biomolecular Chemistry, 2011Minoxidil (2,4-diamino-6-(piperidin-1'-yl)pyrimidine N(3)-oxide; CASRN 38304-91-5) is a bioactive molecule with several nitrosatable groups widely used as an antihypertensive and antialopecia agent. Here the nitrosation of minoxidil was investigated. The conclusions drawn are as follows: (i) In the pH = 2.3-5.0 range, the minoxidil molecule undergoes ...
Mario, González-Jiménez +3 more
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Nitrosation by alkyl nitrites. Part 6. Thiolate nitrosation
Journal of the Chemical Society, Perkin Transactions 2, 1990Each of the following thiols react with a range of alkyl nitrites in water at 25 °C in the pH range 6–13 to give the corresponding thionitrites in solution: L-cysteine, N-acetyl-L-cysteine, L-cysteine methyl ester, L-cysteine ethyl ester, glutathione and thioglycolic acid.
Hanif M. S. Patel, D. Lyn H. Williams
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Nitrosative Stress and Transcription
Biological Chemistry, 2003Low NO concentrations synthesized by constitutively expressed NO synthases act on several signaling pathways activating transcription factors (TF), such as NF-kappaB or AP-1, and thereby influence gene expression. In contrast, during inflammatory reactions the inducible NO synthase produces NO for prolonged periods of time.
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