Results 161 to 170 of about 7,232 (217)
Mutagenic products are promoted in the nitrosation of tyramine [PDF]
Food Chemistry, 2017 Tyramine is a biogenic compound derived from the decarboxylation of the amino acid tyrosine, and is therefore present at important concentrations in a broad range of raw and fermented foods.
Mario Gonzalez Jiménez +2 more
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N-Nitrosation in the absence of nitrosating agents in pharmaceuticals?
Journal of Pharmaceutical and Biomedical Analysis, 2022The possibility of N-Nitrosation in the absence of nitrosating agents was studied on model solutions and film coated tablets containing metformin. N-nitrosodimethylamine (NDMA) and N-nitrosation precursors (dimethylamine and nitrites) were determined using previously published fully validated analytical methods. Alternative routes to N-nitrosation were
Jakub, Jireš +3 more
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The Journal of Organic Chemistry, 2004
The acidic nitrosation chemistry of nine acyclic secondary and tertiary amidines (Ph-N=C(R(1))NR(2)R(3); R(1) = H, CH(3), Ph; R(2), R(3) = H, Ph or (CH(3))(2) or C(CH(2))(4)) and several N-acylamidines was investigated. The principal nitrosation products were amides derived from the amino moiety and compounds derived from the benzenediazonium ion ...
Richard N, Loeppky, Hongbin, Yu
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The acidic nitrosation chemistry of nine acyclic secondary and tertiary amidines (Ph-N=C(R(1))NR(2)R(3); R(1) = H, CH(3), Ph; R(2), R(3) = H, Ph or (CH(3))(2) or C(CH(2))(4)) and several N-acylamidines was investigated. The principal nitrosation products were amides derived from the amino moiety and compounds derived from the benzenediazonium ion ...
Richard N, Loeppky, Hongbin, Yu
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1993
Humans are exposed through ingestion or inhalation to preformed N-nitroso compounds (NOC) in the environment and through the endogenous nitrosation of amino precursors in the body. Activated macrophages and bacterial strains isolated from human infections can enzymatically produce nitrosating agents and NOC from precursors at neutral pH.
H, Bartsch +3 more
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Humans are exposed through ingestion or inhalation to preformed N-nitroso compounds (NOC) in the environment and through the endogenous nitrosation of amino precursors in the body. Activated macrophages and bacterial strains isolated from human infections can enzymatically produce nitrosating agents and NOC from precursors at neutral pH.
H, Bartsch +3 more
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Environmental Letters, 1972
Abstract Fresh, partially decomposed, and aged manure samples were examined for the presence of nitrates, nitrites and secondary amines, precursors of nitrosamines. Nitrate, nitrite and total amine nitrogen were found in amounts ranging from 53.2 to 202.3 ppm; 37.1 to 51.9 ppm; and 12.7 to 28.4 ppm, respectively.
P D, Bergstrom +2 more
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Abstract Fresh, partially decomposed, and aged manure samples were examined for the presence of nitrates, nitrites and secondary amines, precursors of nitrosamines. Nitrate, nitrite and total amine nitrogen were found in amounts ranging from 53.2 to 202.3 ppm; 37.1 to 51.9 ppm; and 12.7 to 28.4 ppm, respectively.
P D, Bergstrom +2 more
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Genotoxicity of nitrosated ranitidine
Carcinogenesis, 1983The in vitro reaction of nitrite with the histamine H2-receptor antagonist ranitidine, in acidified solutions or in human gastric juice, resulted in the formation of genotoxic derivatives, mainly eliciting base-pair substitutions in his-Salmonella typhimurium and trp- Escherichia coli and inducing an increased lethality in DNA repair-deficient bacteria.
S, De Flora +3 more
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Mutagenicity of nitrosated cimetidines
Carcinogenesis, 1981Dinitrosocimetidine and mononitrosocimetidine were tested in a series of short term assay systems. Both compounds were mutagenic in the absence of rat liver microsomes. The dinitrosocimetidine produced higher mutagenic or clastogenic effects at concentrations that were 50 to 500 times lower than the concentrations at which the mononitrosocimetidine ...
D, Ichinotsubo +4 more
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in vitro nitrosation of methapyrilene
Journal of Pharmaceutical Sciences, 1979The reactions of sodium nitrite and methapyrilene were studied in aqueous solution at neutral pH and under simulated gastric fluid conditions. Reaction product formation was much more complex than nitrosation of the parent molecule dimethylamino moiety to form nitrosodimethylamine. Several new nitroso compounds were formed under the reaction conditions
W J, Mergens +4 more
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The role of a formaldehyde dehydrogenase–glutathione pathway in protein S-nitrosation in mammalian cells [PDF]
Nitric Oxide - Biology and Chemistry, 2003 Intracellular sulfhydryls, both protein and non-protein, are potential targets of nitric oxide-related species. S-Nitrosation of proteins can occur in vivo and can affect their activity.
H Chaim Birnboim
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Nitrosation of benzoxazolinone
Bulletin of Environmental Contamination and Toxicology, 19762(3)-benzoxazolinone (I) has been isolated from rye (Virtanen and Hietala, 19557, corn, and wheat (Virtanen, et al., 1956). It was later found that this compound is stored in the plant as the glucoside of 1,4-~enzoxzinone and is formed when the plant is injured. Kl~p and Robinson (1969) found concentrations as high as 1.4 mg/g in inbred strains of corn
openaire +2 more sources