S-Nitrosoglutathione Reductase—The Master Regulator of Protein S-Nitrosation in Plant NO Signaling [PDF]
Plants, 2019 S-nitrosation has been recognized as an important mechanism of protein posttranslational regulations, based on the attachment of a nitroso group to cysteine thiols.
Jana Jahnová +2 more
exaly +4 more sources
S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension [PDF]
Redox Biology, 2019 Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation ...
Yuying Zhang, Nanping Wang, Lei Xiao
exaly +4 more sources
Deciphering the Path of S-nitrosation of Human Thioredoxin: Evidence of an Internal NO Transfer and Implication for the Cellular Responses to NO [PDF]
Antioxidants, 2022 Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved mainly through S-nitrosation where thioredoxin (hTrx) is pivotal in the S-transnitrosation to specific cellular targets.
Vitor S. Almeida +6 more
doaj +2 more sources
S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis [PDF]
Frontiers in Plant Science, 2022 E3 ubiquitin ligases mediate the last step of the ubiquitination pathway in the ubiquitin-proteasome system (UPS). By targeting transcriptional regulators for their turnover, E3s play a crucial role in every aspect of plant biology.
Maria Cecilia Terrile +15 more
doaj +2 more sources
Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells [PDF]
Redox Biology, 2020 Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized.
Aleksandra Kopacz +11 more
doaj +2 more sources
GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation [PDF]
Redox Biology, 2021 Innate immunity is the first line of host defense against pathogens. This process is modulated by multiple antiviral protein modifications, such as phosphorylation and ubiquitination.
Qianjin Liu +11 more
doaj +2 more sources
Proteomic Analysis of S-Nitrosation Sites During Somatic Embryogenesis in Brazilian Pine, Araucaria angustifolia (Bertol.) Kuntze [PDF]
Frontiers in Plant Science, 2022 Cysteine S-nitrosation is a redox-based post-translational modification that mediates nitric oxide (NO) regulation of various aspects of plant growth, development and stress responses.
Alexandre Junio Borges Araujo +8 more
doaj +2 more sources
Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants [PDF]
Plants, 2020 S-nitrosation has been recognized as an important mechanism of ubiquitous posttranslational modification of proteins on the basis of the attachment of the nitroso group to cysteine thiols.
Tereza Jedelská +2 more
doaj +2 more sources
Arginine-Dependent Nitric Oxide Generation and S-Nitrosation in the Non-Photosynthetic Unicellular Alga Polytomella parva [PDF]
Antioxidants, 2022 Nitric oxide (NO) acts as a key signaling molecule in higher plants, regulating many physiological processes. Several photosynthetic algae from different lineages are also known to produce NO.
Tatiana Lapina +3 more
doaj +2 more sources
S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation [PDF]
Redox BiologyMorphine, a typical opiate, is widely used for controlling pain but can lead to various side effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia.
Ling-Yan Su +10 more
doaj +2 more sources