Phytophthora Disrupts Plant Immunity by Manipulating Nitric Oxide Homeostasis Through GSNOR Inhibition [PDF]
Advanced ScienceNitric oxide (NO), a pivotal redox signaling molecule, coordinates plant development and immune responses through S‐nitrosylation‐mediated protein modification. While NO‐dependent S‐nitrosylation fine‐tunes immune responses, whether pathogens hijack this
Tingting Li +8 more
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Modulation of GSNOR activity for improved NO homeostasis and flood resilience in plants [PDF]
Plant Signaling & BehaviorFlood-induced hypoxia (low oxygen concentration) is increasing in frequency and intensity due to climate change, leading to significant crop yield losses and posing a major threat to global food security.
Thea Wulf +2 more
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GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation
Redox Biology, 2021 Innate immunity is the first line of host defense against pathogens. This process is modulated by multiple antiviral protein modifications, such as phosphorylation and ubiquitination.
Yong-Gang Yao, Chang Chen, Ling Xu
exaly +5 more sources
GSNOR is essential for nitric oxide homeostasis and involved in aflatoxin biosynthesis and pathogenicity in Aspergillus flavus [PDF]
Applied and Environmental MicrobiologyNitric oxide (NO) is an important biological signaling molecule. S-nitrosoglutathione reductase (GSNOR), a master regulator of NO signaling, regulates various biological processes.
Dongyue Chen +3 more
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S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1 [PDF]
Nature CommunicationsAge-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood.
Xinhua Qiao +16 more
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S-nitrosoglutathione reductase disfavors cadmium tolerance in shoots of Arabidopsis [PDF]
Scientific ReportsS-nitrosoglutathione reductase (GSNOR) is involved in the response to cadmium (Cd) exposure. In this study, the plants of mutant (gsnor1-3) with lossing-function of- and over-expression (GSNOR OE 5) of GSNOR were used to clear the role of GSNOR in Cd ...
Meiyan Guan, Xiaolong Zheng, Yaxin Zhu
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Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits [PDF]
Redox BiologyIntroduction: Overexpression of arginase-1 (ARG1) in red blood cells (RBCs) is associated with endothelial dysfunction, and short-term ARG1 inhibition or l-arginine supplementation restored endothelial function.
Rajinikanth Gogiraju +16 more
doaj +2 more sources
S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation [PDF]
Redox BiologyMorphine, a typical opiate, is widely used for controlling pain but can lead to various side effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia.
Ling-Yan Su +10 more
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Obesity-associated lysosomal nitrosative stress promotes retinopathy [PDF]
Biology DirectBackground Obesity and diabetes are major risk factors causing vision loss around the world, yet the molecular mechanisms linking obesity to retinal pathology remain incompletely understood.
Qingwen Qian +4 more
doaj +2 more sources
GSNOR plays roles in growth, pathogenicity, and stress resistance by modulating mitochondrial protein COX6B S-nitrosylation in Colletotrichum gloeosporioides [PDF]
mBioNitric oxide (NO) serves as a versatile signaling molecule governing diverse biological processes, primarily through post-translational modifications such as S-nitrosylation.
Xing Yang +6 more
doaj +2 more sources