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Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease

open access: yesAntioxidants, 2020
Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive impairment (MCI).
D. Allan Butterfield, Debra Boyd-Kimball
doaj   +3 more sources

Nitrosative stress in Parkinson’s disease

open access: yesnpj Parkinson's Disease, 2022
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss of dopaminergic neurons within the nigral-striatal pathway. Multiple lines of evidence support a role for reactive nitrogen species (RNS) in degeneration of this
Morgan G. Stykel, Scott D. Ryan
doaj   +3 more sources

Obesity-associated lysosomal nitrosative stress promotes retinopathy [PDF]

open access: yesBiology Direct
Background Obesity and diabetes are major risk factors causing vision loss around the world, yet the molecular mechanisms linking obesity to retinal pathology remain incompletely understood.
Qingwen Qian   +4 more
doaj   +2 more sources

The critical role of hcpR in regulating nitrosative stress defense in Clostridioides difficile [PDF]

open access: yesApplied and Environmental Microbiology
Clostridioides difficile is an anaerobic, toxin-producing pathogen that colonizes the host gastrointestinal tract. Within this hostile environment, the bacterium encounters stressors such as reactive nitrogen species (RNS), which impose nitrosative ...
Sanjana Kalra   +2 more
doaj   +2 more sources

Metallothionein Cup1 attenuates nitrosative stress in the yeast Saccharomyces cerevisiae [PDF]

open access: yesMicrobial Cell, 2022
Metallothionein (MT), which is a small metal-binding protein with cysteine-rich motifs, functions in the detoxification of heavy metals in a variety of organisms.
Yuki Yoshikawa   +3 more
doaj   +2 more sources

Mediating role of oxidative/nitrosative stress biomarkers in the associations between phthalate exposure and thyroid function in Taiwanese adults

open access: yesEnvironment International, 2020
Phthalate exposure was shown to alter thyroid function, however it is unclear, whether oxidative and nitrosative stress explains the intermediate biological mechanism. This study aimed to investigate the associations between phthalate exposure, oxidative/
Po-Chin Huang   +5 more
doaj   +3 more sources

Redox and Nitrosative Signaling and Stress [PDF]

open access: yesAntioxidants, 2020
In this Special Issue, redox/nitrosative signaling has been considered in several aspects of cardiosciences and oncology, namely cardioncology [...]
Claudia Penna
doaj   +3 more sources

Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson’s Disease Pathogenesis: The Dual Role of Reactive Astrocytes

open access: yesAntioxidants, 2019
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide; it is characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta, but its etiology is not fully understood.
Asha Rizor   +4 more
doaj   +3 more sources

Klebsiella pneumoniae factors enhancing bacteremia have distinct contributions to macrophage-mediated, oxidative, and nitrosative stress resistance [PDF]

open access: yesInfection and Immunity
Klebsiella pneumoniae is a Gram-negative species that is a leading cause of hospital-associated infections. Such infections can result in bacteremia, when bacteria disseminate to the bloodstream and colonize filtering organs.
Alexis E. Wilcox   +3 more
doaj   +2 more sources

The Interplay between Nitrosative Stress, Inflammation, and Antioxidant Defense in Patients with Lichen Planus [PDF]

open access: yesAntioxidants
Background: Lichen planus (LP) is a chronic inflammatory skin disease of unelucidated etiology. LP immunopathogenesis is mainly governed by cytotoxic T lymphocytes that mediate an immune response in basal keratinocytes, which may transform into a ...
Mircea Tampa   +6 more
doaj   +2 more sources

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