Results 21 to 30 of about 1,125 (150)

ADH IB expression, but not ADH III, is decreased in human lung cancer. [PDF]

PLoS ONE, 2012
Endogenous S-nitrosothiols, including S-nitrosoglutathione (GSNO), mediate nitric oxide (NO)-based signaling, inflammatory responses, and smooth muscle function.
Sarah C Mutka, Lucia H Green, Evie L Verderber, Jane P Richards, Doug L Looker, Elizabeth A Chlipala, Gary J Rosenthal   +6 more
doaj   +1 more source

S‐Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S‐Nitrosylation and Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S‐nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and ...
Shathiyah Kulandavelu, Raul A. Dulce, Christopher I. Murray, Michael A. Bellio, Julia Fritsch, Rosemeire Kanashiro‐Takeuchi, Himanshu Arora, Ellena Paulino, Daniel Soetkamp, Wayne Balkan, Jenny E. Van Eyk, Joshua M. Hare   +11 more
doaj   +1 more source

Pharmacological Inhibition of S-Nitrosoglutathione Reductase Reduces Cardiac Damage Induced by Ischemia–Reperfusion

Antioxidants, 2021
The cardioprotective effects of nitric oxide (NO) have been described through S-nitrosylation of several important proteins in the mitochondria of the cardiomyocyte.
Oscar Arriagada Castillo, Gustavo Herrera, Carlos Manriquez, Andrea F. Rojas, Daniel R. González   +4 more
doaj   +1 more source

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis [PDF]

Cell Death & Disease, 2019
AbstractNeuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal muscle function due, at least in part, to S-nitrosylation of specific protein targets. Similarly, we recently provided evidence for a muscular phenotype in mice lacking the denitrosylase S-nitrosoglutathione reductase (GSNOR).
Montagna, Costanza, Rizza, Salvatore, Cirotti, Claudia, Maiani, Emiliano, Muscaritoli, Maurizio, Musarò, Antonio, Carrí, Maria Teresa, Ferraro, Elisabetta, Cecconi, Francesco, Filomeni, Giuseppe   +9 more
openaire   +5 more sources

Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration

Cell Reports, 2021
Summary: Hematopoietic stem cells (HSCs) regenerate blood cells upon hematopoietic injuries. During homeostasis, HSCs are maintained in a low reactive oxygen species (ROS) state to prevent exhaustion. However, the role of nitric oxide (NO) in controlling
Weiwei Yi, Yuying Zhang, Bo Liu, Yuanyuan Zhou, Dandan Liao, Xinhua Qiao, Dan Gao, Ting Xie, Qin Yao, Yao Zhang, Yugang Qiu, Gang Huang, Zhiyang Chen, Chang Chen, Zhenyu Ju   +14 more
doaj   +1 more source

The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2017
S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate. GSNOR metabolizes S-nitrosoglutathione (GSNO), S-hydroxymethylglutathione (the spontaneous adduct of formaldehyde and glutathione),
Barnett, Scott D., Buxton, Iain L. O.
openaire   +3 more sources

Arabidopsis CaM1 and CaM4 Promote Nitric Oxide Production and Salt Resistance by Inhibiting S-Nitrosoglutathione Reductase via Direct Binding. [PDF]

PLoS Genetics, 2016
Salt is a major threat to plant growth and crop productivity. Calmodulin (CaM), the most important multifunctional Ca2+ sensor protein in plants, mediates reactions against environmental stresses through target proteins; however, direct proof of the ...
Shuo Zhou, Lixiu Jia, Hongye Chu, Dan Wu, Xuan Peng, Xu Liu, Jiaojiao Zhang, Junfeng Zhao, Kunming Chen, Liqun Zhao   +9 more
doaj   +1 more source

S-Nitrosoglutathione Reductase Contributes to Thermotolerance by Modulating High Temperature-Induced Apoplastic H2O2 in Solanum lycopersicum

Frontiers in Plant Science, 2022
S-nitrosoglutathione reductase (GSNOR) is considered as a critical regulator of plant stress tolerance for its impacts on protein S-nitrosylation through regulation of the S-nitrosothiol (SNO) level.
Xuewei Song, Ting Wang, Yang Zhang, Jing-Quan Yu, Jing-Quan Yu, Xiao-Jian Xia   +5 more
doaj   +1 more source

S-nitrosoglutathione reductases are low-copy number, cysteine-rich proteins in plants that control multiple developmental and defense responses in Arabidopsis.

Frontiers in Plant Science, 2013
S-nitrosoglutathione reductase (GSNOR) is believed to modulate effects of reactive oxygen and nitrogen species through catabolism of S-nitrosoglutathione (GSNO).
Shengbao eXu, Damian eGuerra, Ung eLee, Elizabeth eVierling   +3 more
doaj   +1 more source

S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity. [PDF]

PLoS ONE, 2013
Allergic asthma is characterized by Th2 type inflammation, leading to airway hyperresponsivenes, mucus hypersecretion and tissue remodeling. S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of intracellular ...
Maria E Ferrini, Bryan J Simons, David J P Bassett, Matthews O Bradley, Kevan Roberts, Zeina Jaffar   +5 more
doaj   +1 more source