Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction [PDF]
CellsIn cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)—which is involved in receptor desensitization and internalization—are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes
Gizem Kayki Mutlu +6 more
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S-nitrosylation of cardiac myocyte proteins may underlie sex differences in cardiac disease [PDF]
Frontiers in PhysiologyNitric oxide (NO) plays several critical roles in cardiovascular physiology. This molecule regulates cardiac function by modifying Ca2+-handling proteins through a process known as S-nitrosylation.
Esther U. Asamudo +3 more
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Aberrant protein S-nitrosylation disrupts axonal development and metabolic homeostasis in a Cntnap2 mouse model of autism [PDF]
Redox BiologyProtein S-nitrosylation (SNO) is a nitric oxide (·NO)-dependent post-translational modification that regulates various biological functions. Dysregulated SNO is involved in several brain disorders; however, its role in autism spectrum disorder (ASD ...
Maryam Kartawy +3 more
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S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis [PDF]
Nature CommunicationsNitric oxide (NO), a versatile bio-active molecule modulates cellular functions through diverse mechanisms including S-nitrosylation of proteins.
Ashima Sakhuja +11 more
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Protein-S-nitrosylation of human cytomegalovirus pp65 reduces its ability to undermine cGAS [PDF]
Journal of VirologyPost-translational modifications (PTMs) are key regulators of various processes important for cell survival. These modifications are critical for dealing with stress conditions, such as those observed in disease states, and during infections with various
Justin B. Cox +2 more
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S-nitrosylation of paired-related homeobox 1 promotes cardiac remodeling following myocardial infarction [PDF]
Redox BiologyBackgrounds: Cardiac remodeling, mediated by fibroblast-to-myofibroblast differentiation, is a key pathophysiologic step to determine the prognosis of patients following myocardial infarction (MI).
Dashuai Wang +8 more
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S-Nitrosylation in Cardiovascular Disorders: The State of the Art [PDF]
BiomoleculesProtein S-nitrosylation is a selective post-translational modification in which a nitrosyl group is covalently attached to the reactive thiol group of cysteine, forming S-nitrosothiol.
Caiyun Mao +6 more
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Metabolic modulation of TCA cycle by S-nitrosylation in Monascus spp. [PDF]
Synthetic and Systems BiotechnologyMonascus spp. produces several beneficial secondary metabolites (SMs), such as Monacolin K and Monascus pigments, which have wide applications in the pharmaceutical and food industries.
Zitong Meng +3 more
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Nature Communications, 2023 Reversible protein S-nitrosylation regulates a wide range of biological functions and physiological activities in plants. However, it is challenging to quantitively determine the S-nitrosylation targets and dynamics in vivo.
Guochen Qin +7 more
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Computational prediction of candidate proteins for S-nitrosylation in Arabidopsis thaliana. [PDF]
PLoS ONE, 2014 Nitric oxide (NO) is an important signaling molecule that regulates many physiological processes in plants. One of the most important regulatory mechanisms of NO is S-nitrosylation-the covalent attachment of NO to cysteine residues.
Mounira Chaki +3 more
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