S-nitrosylation of EZH2 alters PRC2 assembly, methyltransferase activity, and EZH2 stability to maintain endothelial homeostasis [PDF]
Nature CommunicationsNitric oxide (NO), a versatile bio-active molecule modulates cellular functions through diverse mechanisms including S-nitrosylation of proteins.
Syamantak Majumder +2 more
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Redox Biology, 2021 Protein S-nitrosylation is a reversible protein modification implicated in both physiological and pathophysiological regulation of protein function.
Jian Xiao, Yu Zhu, Xiaokun Li
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S-nitrosylation of cardiac myocyte proteins may underlie sex differences in cardiac disease [PDF]
Frontiers in PhysiologyNitric oxide (NO) plays several critical roles in cardiovascular physiology. This molecule regulates cardiac function by modifying Ca2+-handling proteins through a process known as S-nitrosylation.
Esther U. Asamudo +3 more
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Aberrant protein S-nitrosylation disrupts axonal development and metabolic homeostasis in a Cntnap2 mouse model of autism [PDF]
Redox BiologyProtein S-nitrosylation (SNO) is a nitric oxide (·NO)-dependent post-translational modification that regulates various biological functions. Dysregulated SNO is involved in several brain disorders; however, its role in autism spectrum disorder (ASD ...
Maryam Kartawy +3 more
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Protein-S-nitrosylation of human cytomegalovirus pp65 reduces its ability to undermine cGAS [PDF]
Journal of VirologyPost-translational modifications (PTMs) are key regulators of various processes important for cell survival. These modifications are critical for dealing with stress conditions, such as those observed in disease states, and during infections with various
Justin B. Cox +2 more
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S-nitrosylation of paired-related homeobox 1 promotes cardiac remodeling following myocardial infarction [PDF]
Redox BiologyBackgrounds: Cardiac remodeling, mediated by fibroblast-to-myofibroblast differentiation, is a key pathophysiologic step to determine the prognosis of patients following myocardial infarction (MI).
Dashuai Wang +8 more
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S-Nitrosylation in Cardiovascular Disorders: The State of the Art [PDF]
BiomoleculesProtein S-nitrosylation is a selective post-translational modification in which a nitrosyl group is covalently attached to the reactive thiol group of cysteine, forming S-nitrosothiol.
Caiyun Mao +6 more
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GPS-SNO: Computational Prediction of Protein S-Nitrosylation Sites with a Modified GPS Algorithm
PLoS ONE, 2010 As one of the most important and ubiquitous post-translational modifications (PTMs) of proteins, S-nitrosylation plays important roles in a variety of biological processes, including the regulation of cellular dynamics and plasticity. Identification of S-
Ze-Xian Liu, Jian Ren, Yu Xue
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S-Nitrosylation: An Emerging Paradigm of Redox Signaling
Antioxidants, 2019 Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple human diseases, including cancer.
Vandana Sharma +2 more
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Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet [PDF]
Journal of Lipid ResearchNitric oxide (NO), produced primarily by nitric oxide synthase enzymes, is known to influence energy metabolism by stimulating fat uptake and oxidation. The effects of NO on de novo lipogenesis (DNL), however, are less clear.
Nicholas M. Venetos +4 more
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