Results 41 to 50 of about 15,774 (176)

Regulation of DNA repair by S-nitrosylation [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2012
Expression of the inducible nitric oxide synthase (iNOS) is commonly induced in inflammation, an important risk factor of cancer. Nitric oxide (NO) and related reactive nitrogen species can directly cause DNA damage to increase DNA mutation. They can also indirectly affect DNA mutation by modulation of DNA repair proteins, in particular through protein
Chi-Hui, Tang, Wei, Wei, Limin, Liu
openaire   +2 more sources

Nitric Oxide Synthase 1 Modulates Basal and β-Adrenergic-Stimulated Contractility by Rapid and Reversible Redox-Dependent S-Nitrosylation of the Heart.

PLoS ONE, 2016
S-nitrosylation of several Ca2+ regulating proteins in response to β-adrenergic stimulation was recently described in the heart; however the specific nitric oxide synthase (NOS) isoform and signaling pathways responsible for this modification have not ...
Alejandra Z Vielma, Luisa León, Ignacio C Fernández, Daniel R González, Mauricio P Boric   +4 more
doaj   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Light‐evoked S‐nitrosylation in the retina [PDF]

Journal of Comparative Neurology, 2015
ABSTRACTNitric oxide (NO) synthesis in the retina is triggered by light stimulation. NO has been shown to modulate visual signal processing at multiple sites in the vertebrate retina, via activation of the most sensitive target of NO signaling, soluble guanylate cyclase.
Ryan E, Tooker, Jozsef, Vigh
openaire   +2 more sources

Arsenic Modulates Posttranslational S-Nitrosylation and Translational Proteome in Keratinocytes

The Scientific World Journal, 2014
Arsenic is a class I human carcinogen (such as inducing skin cancer) by its prominent chemical interaction with protein thio (-SH) group. Therefore, arsenic may compromise protein S-nitrosylation by competing the -SH binding activity.
Bin Huang, Kuo-Hao Chiang, Hsin-Su Yu, Ying-Lun Chen, Huey-Ling You, Wei-Ting Liao   +5 more
doaj   +1 more source

Suppression of VEGFD expression by S-nitrosylation promotes the development of lung adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Vascular endothelial growth factor D (VEGFD), a member of the VEGF family, is implicated in angiogenesis and lymphangiogenesis, and is deemed to be expressed at a low level in cancers.
Qiangqiang He, Meiyu Qu, Tingyu Shen, Yana Xu, Jiahao Luo, Dan Tan, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu   +9 more
doaj   +1 more source

RecSNO: Prediction of Protein S-Nitrosylation Sites Using a Recurrent Neural Network

IEEE Access, 2021
S-Nitrosylation modification is one of the most important post-translational modifications; it plays a critical role in a vast variety of biological processes and is related to various diseases.
Arslan Siraj, Tuvshinbayar Chantsalnyam, Hilal Tayara, Kil To Chong   +3 more
doaj   +1 more source

S-Nitrosylation of Cardiac Ion Channels [PDF]

Journal of Cardiovascular Pharmacology, 2009
Nitric oxide (NO) exerts ubiquitous signaling via posttranslational modification of cysteine residues, a reaction termed S-nitrosylation. Important substrates of S-nitrosylation that influence cardiac function include receptors, enzymes, ion channels, transcription factors, and structural proteins. Cardiac ion channels subserving excitation-contraction
Daniel R, Gonzalez, Adriana, Treuer, Qi-An, Sun, Jonathan S, Stamler, Joshua M, Hare   +4 more
openaire   +2 more sources

Cellular Membrane‐Targeted Europium(III) Probe for Selective and Time‐Resolved Detection of Peroxynitrite

Chemistry – A European Journal, EarlyView.
We report a cellular membrane‐targeted europium(III) probe, Eu.Chol, that enables selective, time‐resolved detection of peroxynitrite (ONOO−) at the cell membrane interface. Eu.Chol demonstrates efficient incorporation into liposomes and Jurkat cells, with minimal response to H2O2, establishing a modular platform for subcellular ONOO− sensing ...
Jamie Webb, Rebecca Tiffany, Karolis Norvaisa, Hennie Valkenier, Lea Miebach, Sander Bekeschus, Stephen J. Butler   +6 more
wiley   +1 more source

S-nitrosylation-regulated GPCR signaling [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2012
G protein-coupled receptors (GPCRs) are the most numerous and diverse type of cell surface receptors, accounting for about 1% of the entire human genome and relaying signals from a variety of extracellular stimuli that range from lipid and peptide growth factors to ions and sensory inputs.
unknown ( host institution ), Daaka, Yehia ( author )   +1 more
openaire   +3 more sources