Results 51 to 60 of about 15,774 (176)
Redox BiologyNitric oxide (NO) influences a multitude of physiological and pathological processes. A major part of NO signaling involves S-nitrosylation (SNO), a post-translational modification in which an NO moiety is added to a selective cysteine thiol of a protein
Mélina Meunier +2 more
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Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia. [PDF]
PLoS ONE, 2013 Hypoglycemia is a severe side effect of intensive insulin therapy. Recurrent hypoglycemia (RH) impairs the counter-regulatory response (CRR) which restores euglycemia.
Xavier Fioramonti +11 more
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Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security
Journal of the Science of Food and Agriculture, EarlyView.Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori +9 more
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Nature Communications, 2023 Treatment of Staphylococcus aureus infections is a constant challenge due to emerging resistance to vancomycin, a last-resort drug. S-nitrosylation, the covalent attachment of a nitric oxide (NO) group to a cysteine thiol, mediates redox-based signaling ...
Xueqin Shu +4 more
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Medicinal Research Reviews, EarlyView.ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay +3 more
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S-Nitrosylation in neurogenesis and neuronal development [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015 Nitric oxide (NO) is a pleiotropic messenger molecule. The multidimensional actions of NO species are, in part, mediated by their redox nature. Oxidative posttranslational modification of cysteine residues to regulate protein function, termed S-nitrosylation, constitutes a major form of redox-based signaling by NO.S-Nitrosylation directly modifies a ...
Shu-ichi, Okamoto, Stuart A, Lipton
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SNOSite: exploiting maximal dependence decomposition to identify cysteine S-nitrosylation with substrate site specificity. [PDF]
PLoS ONE, 2011 S-nitrosylation, the covalent attachment of a nitric oxide to (NO) the sulfur atom of cysteine, is a selective and reversible protein post-translational modification (PTM) that regulates protein activity, localization, and stability.
Tzong-Yi Lee +4 more
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Responsive Materials, EarlyView.This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun +8 more
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S-nitrosylation of Ras in breast cancer [PDF]
Breast Cancer Research, 2012 Elevated expression of nitric oxide synthase 2 has been recently shown to correlate with poor survival in estrogen receptor-negative breast cancer. In an article in Breast Cancer Research, Switzer and colleagues identify the transcription factor Ets-1 as a critical mediator of nitric oxide-dependent oncogenic gene expression in basal-like breast cancer.
Marshall, Harvey E, Foster, Matthew W
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Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application
Responsive Materials, EarlyView.Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li +5 more
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