Results 31 to 40 of about 15,774 (176)

S-nitrosylation of fatty acid synthase regulates its activity through dimerization[S]

Journal of Lipid Research, 2016
NO regulates a variety of physiological processes, including cell proliferation, differentiation, and inflammation. S-nitrosylation, a NO-mediated reversible protein modification, leads to changes in the activity and function of proteins.
Min Sik Choi, Ji-Yong Jung, Hyoung-June Kim, Mi Ra Ham, Tae Ryong Lee, Dong Wook Shin   +5 more
doaj   +1 more source

GSNOR regulates ganoderic acid content in Ganoderma lucidum under heat stress through S-nitrosylation of catalase

Communications Biology, 2022
Liu et al. identify catalase as a target of S-nitrosylation by GSNOR and the specific sites of S-nitrosylation critical for its role in regulating secondary metabolite production in Ganoderma lucidum under heat stress.
Rui Liu, Ting Zhu, Xin Chen, Zi Wang, Zhengyan Yang, Ang Ren, Liang Shi, Hanshou Yu, Mingwen Zhao   +8 more
doaj   +1 more source

AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

Cell Reports, 2020
Summary: The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory.
George K.E. Umanah, Mehdi Ghasemi, Xiling Yin, Melissa Chang, Jin Wan Kim, Jianmin Zhang, Erica Ma, Leslie A. Scarffe, Yun-Il Lee, Rong Chen, Kavya Tangella, Amy McNamara, Leire Abalde-Atristain, Mohamad A. Dar, Samuel Bennett, Marisol Cortes, Shaida A. Andrabi, Paschalis-Thomas Doulias, Harry Ischiropoulos, Ted M. Dawson, Valina L. Dawson   +20 more
doaj   +1 more source

S‐Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S‐Nitrosylation and Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S‐nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and ...
Shathiyah Kulandavelu, Raul A. Dulce, Christopher I. Murray, Michael A. Bellio, Julia Fritsch, Rosemeire Kanashiro‐Takeuchi, Himanshu Arora, Ellena Paulino, Daniel Soetkamp, Wayne Balkan, Jenny E. Van Eyk, Joshua M. Hare   +11 more
doaj   +1 more source

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

S-nitrosylation of SlAPX Is Involved in Alleviating Oxidative Damage in Transgenic Tobacco under Nitrate Stress

Agronomy, 2023
Nitric oxide (NO) modulates plant response by post-translationally modifying proteins, mainly through S-nitrosylation. Ascorbate peroxidase (APX) in the ascorbate-glutathione (AsA-GSH) cycle participates in the removal of hydrogen peroxide (H2O2 ...
Chuntao Lv, Yuanlin Liang, Manqi Wang, Kunzhi Li, Xudong Sun, Huini Xu   +5 more
doaj   +1 more source

Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo

Redox Biology, 2022
Background: s: Hyperhomocysteinemia (HHcy) is one of risk factors for vascular cognitive impairment (VCI). GTP cyclohydrolase 1 (GCH1) deficiency is critical to oxidative stress in vascular dysfunction.
Ya-Ling Yin, Yuan Chen, Feng Ren, Lu Wang, Mo-Li Zhu, Jun-Xiu Lu, Qian-Qian Wang, Cheng-Biao Lu, Chao Liu, Yong-Ping Bai, Shuang-Xi Wang, Jian-Zhi Wang, Peng Li   +12 more
doaj   +1 more source

Protein S-nitrosylation in preconditioning and postconditioning [PDF]

Experimental Biology and Medicine, 2014
The coronary artery disease is a leading cause of death and morbidity worldwide. This disease has a complex pathophysiology that includes multiple mechanisms. Among these is the oxidative/nitrosative stress. Paradoxically, oxidative/nitrosative signaling plays a major role in cardioprotection against ischemia/reperfusion injury.
Claudia, Penna, Carmelina, Angotti, Pasquale, Pagliaro   +2 more
openaire   +2 more sources

iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin

BMC Musculoskeletal Disorders, 2020
Background Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx mice) and that both neuronal NOS (nNOS) and inducible NOS (iNOS) might contribute to the
Ken’ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Fusako Sakai-Takemura, Jun Tanihata, Jun-ichi Kira, Yuko Miyagoe-Suzuki, Shin’ichi Takeda   +7 more
doaj   +1 more source

S-Nitrosylation at the Interface of Autophagy and Disease [PDF]

Molecular Cell, 2011
In this issue of Molecular Cell, Sarkar et al. (2011) provide the first evidence for involvement of nitric oxide bioactivity in autophagy and suggest new insight into the role of aberrant S-nitrosylation in the pathogenesis of neurodegeneration.
Haldar, Saptarsi M., Stamler, Jonathan S.   +1 more
openaire   +2 more sources