Results 11 to 20 of about 1,125 (150)

De‐nitrosylation Coordinates Appressorium Function for Infection of the Rice Blast Fungus [PDF]

Advanced Science
As a signaling molecule, nitric oxide (NO) regulates the development and stress response in different organisms. The major biological activity of NO is protein S‐nitrosylation, whose function in fungi remains largely unclear.
Hong Hu, Wenhui He, Zhiguang Qu, Xiang Dong, Zhiyong Ren, Mengyuan Qin, Hao Liu, Lu Zheng, Junbin Huang, Xiao‐Lin Chen   +9 more
doaj   +3 more sources

GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation [PDF]

Cell Reports, 2023
Summary: Nitric oxide (NO) production in the tumor microenvironment is a common element in cancer. S-nitrosylation, the post-translational modification of cysteines by NO, is emerging as a key transduction mechanism sustaining tumorigenesis.
Salvatore Rizza, Luca Di Leo, Chiara Pecorari, Paola Giglio, Fiorella Faienza, Costanza Montagna, Emiliano Maiani, Michele Puglia, Francesca M. Bosisio, Trine Skov Petersen, Lin Lin, Vendela Rissler, Juan Salamanca Viloria, Yonglun Luo, Elena Papaleo, Daniela De Zio, Blagoy Blagoev, Giuseppe Filomeni   +17 more
doaj   +9 more sources

The Central Role of GSNOR: Decoding Nitric Oxide Signaling for Crop Stress Tolerance [PDF]

International Journal of Molecular Sciences
S-nitrosoglutathione (GSNO) reductase (GSNOR) is a major and conserved enzyme in prokaryotes and eukaryotes. It reduces a stable nitric oxide (NO) reservoir, GSNO, to balance the organisms’ redox status through S-nitrosylation. Over the last few decades, much of our understanding of GSNOR’s roles in plant biology has been updated.
Ashim Kumar Das, Byung-Wook Yun, Bong-Gyu Mun   +2 more
exaly   +4 more sources

GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14 [PDF]

Cellular and Molecular Immunology
Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of numerous diseases. However, the precise molecular mechanisms that modulate the transcriptional regulation of NLRP3 remain largely unknown. In this study, we demonstrated that S-nitrosoglutathione reductase (GSNOR) deficiency in macrophages leads to significant ...
Jinsong Yu, Yong-Gang Yao, Ling-Yan Su   +2 more
exaly   +4 more sources

Hepatocarcinogenesis Driven by GSNOR Deficiency Is Prevented by iNOS Inhibition [PDF]

Cancer Research, 2013
Abstract Hepatocellular carcinoma (HCC) is one of the most common and deadly human cancers and it remains poorly managed. Human HCC development is often associated both with elevated expression of inducible nitric oxide synthase (iNOS) and with genetic deletion of the major denitrosylase S-nitrosoglutathione reductase (GSNOR/ADH5 ...
Tang, Chi-Hui, Wei, Wei, Hanes, Martha A, Liu, Limin   +3 more
  +21 more sources

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S-Nitrosylation of MEK1. [PDF]

Plant Biotechnol J
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Fang H, Wu X, Huang D, Chen X, Liu Z, Pan X, Chen H, Zheng D, Ma C, Hou X, Wang S, Wang C, Liao W.   +12 more
europepmc   +2 more sources

Synergistic Intra- and Inter-Nanozyme Electron Transfer through Interfacial Assembly for Enhanced Multi-Enzyme Activity. [PDF]

Adv Sci (Weinh)
A novel Prussian blue‐based composite nanoenzymes (PB C‐NZs)‐MoS2/PB, was designed based on the electron transfer mechanism and transport pathway. The structure uses MoS2 as the substrate, with PB grown on its surface through a surface assembly method.
Lu K, Liu J, Zhu X, Mao Y, He H, Cai P, Li Y, Gu N.   +7 more
europepmc   +2 more sources

GSNOR Contributes to Demethylation and Expression of Transposable Elements and Stress-Responsive Genes [PDF]

Antioxidants, 2021
In the past, reactive nitrogen species (RNS) were supposed to be stress-induced by-products of disturbed metabolism that cause oxidative damage to biomolecules. However, emerging evidence demonstrates a substantial role of RNS as endogenous signals in eukaryotes. In plants, S-nitrosoglutathione (GSNO) is the dominant RNS and serves as the •NO donor for
Eva Esther Rudolf, Patrick Hüther, Ignasi Forné, Elisabeth Georgii, Yongtao Han, Rüdiger Hell, Markus Wirtz, Axel Imhof, Claude Becker, Jörg Durner, Christian Lindermayr   +10 more
openaire   +4 more sources

Suboptimal zinc supply affects the S-nitrosoglutathione reductase enzyme and nitric oxide signaling in Arabidopsis

Plant Stress, 2023
The S-nitrosoglutathione reductase (GSNOR), a key regulator of nitric oxide (NO) signaling, requires zinc (Zn) cofactors for its catalytic activity. Possible changes in GSNOR function and NO signaling due to limited Zn supply and participation of GSNOR ...
Dóra Oláh, Selahattin Kondak, Árpád Molnár, Oluwatosin Peace Adedokun, Zalán Czékus, Katalin Gémes, Gábor Galbács, Zsuzsanna Kolbert   +7 more
doaj   +1 more source

Exogenous Nitric Oxide Enhances Disease Resistance by Nitrosylation and Inhibition of S-Nitrosoglutathione Reductase in Peach Fruit

Frontiers in Plant Science, 2020
Nitric oxide (NO), a signaling molecule, participates in defense responses during plant–pathogen interactions. S-Nitrosoglutathione (GSNO) is found to be an active intracellular NO storage center and regulated by S-nitrosoglutathione reductase (GSNOR) in
Zifei Yu, Jixuan Cao, Shuhua Zhu, Lili Zhang, Yong Peng, Jingying Shi   +5 more
doaj   +1 more source