Results 1 to 10 of about 2,423 (153)
S‐Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S‐Nitrosylation and Preeclampsia [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S‐nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation and ...
Shathiyah Kulandavelu +11 more
doaj +5 more sources
S-Nitrosoglutathione Reductase in Human Lung Cancer [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2012 Abstract S-Nitrosoglutathione (GSNO) reductase regulates cell signaling pathways relevant to asthma and protects cells from nitrosative stress. Recent evidence suggests that this enzyme may prevent human hepatocellular carcinoma arising in the setting of chronic hepatitis.
Benjamin Gaston +2 more
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S-Nitrosoglutathione Reductase—The Master Regulator of Protein S-Nitrosation in Plant NO Signaling [PDF]
Plants, 2019 S-nitrosation has been recognized as an important mechanism of protein posttranslational regulations, based on the attachment of a nitroso group to cysteine thiols.
Jana Jahnová +2 more
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The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate. GSNOR metabolizes S-nitrosoglutathione (GSNO), S-hydroxymethylglutathione (the spontaneous adduct of formaldehyde and glutathione),
Scott Barnett, Iain Buxton
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Evidence for an Allosteric S-Nitrosoglutathione Binding Site in S-Nitrosoglutathione Reductase (GSNOR) [PDF]
Antioxidants, 2019 Current research has identified S-nitrosoglutathione reductase (GSNOR) as the central enzyme for regulating protein S-nitrosylation. In addition, the dysregulation of GSNOR expression is implicated in several organ system pathologies including respiratory, cardiovascular, hematologic, and neurologic, making GSNOR a primary target for pharmacological ...
Sahar Nikoo +2 more
exaly +4 more sources
S-nitrosoglutathione reductase disfavors cadmium tolerance in shoots of Arabidopsis [PDF]
Scientific ReportsS-nitrosoglutathione reductase (GSNOR) is involved in the response to cadmium (Cd) exposure. In this study, the plants of mutant (gsnor1-3) with lossing-function of- and over-expression (GSNOR OE 5) of GSNOR were used to clear the role of GSNOR in Cd ...
Meiyan Guan, Xiaolong Zheng, Yaxin Zhu
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Gender differences in S-nitrosoglutathione reductase activity in the lung. [PDF]
PLoS ONE, 2010 S-nitrosothiols have been implicated in the etiology of various pulmonary diseases. Many of these diseases display gender preferences in presentation or altered severity that occurs with puberty, the mechanism by which is unknown. Estrogen has been shown
Kathleen Brown-Steinke +3 more
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Localization of S-nitrosoglutathione and expression of S-nitrosoglutathione reductase in pea plants under cadmium stress [PDF]
Journal of Experimental Botany, 2006 S-nitrosoglutathione (GSNO) is considered a natural nitric oxide (NO.) reservoir and a reactive nitrogen intermediate in animal cells, but little is known about this molecule and its metabolism in plant systems. In this work, using pea plants as a model system, the presence of GSNO in collenchyma cells was demonstrated by an immunohistochemical method.
FRANCISCO J Corpas +2 more
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Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma [PDF]
Journal of Allergy and Clinical Immunology, 2007 S-nitrosothiols are potent endogenous bronchodilators depleted in asthmatic airway lining fluid. S-nitrosoglutathione reductase (GSNOR; also known as alcohol dehydrogenase 5 or formaldehyde dehydrogenase) catalyzes the metabolism of S-nitrosoglutathione (GSNO) and controls intracellular levels of S-nitrosothiols. GSNOR knockout mice have increased lung
Stephanie London +2 more
exaly +3 more sources
Advanced ScienceNitric oxide (NO), a pivotal redox signaling molecule, coordinates plant development and immune responses through S‐nitrosylation‐mediated protein modification. While NO‐dependent S‐nitrosylation fine‐tunes immune responses, whether pathogens hijack this
Tingting Li +8 more
doaj +2 more sources