Results 21 to 30 of about 2,423 (153)

Pharmacologic Inhibition of S-Nitrosoglutathione Reductase Prevents Hyperoxic Alveolar and Airway Disease in Newborn Mice [PDF]

Biomedicines
Background/Objectives: Preterm infants are at risk of developing the chronic lung condition of bronchopulmonary dysplasia (BPD), with associated alveolar simplification and airway hyperreactivity.
Stephanie Adaikalam, Ramadan B. Sopi, Laura A. Smith, Anjum Jafri, Peter M. MacFarlane, Richard J. Martin, Benjamin Gaston, Thomas M. Raffay   +7 more
doaj   +2 more sources

Augmentation of CFTR maturation byS-nitrosoglutathione reductase [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2016
S-nitrosoglutathione (GSNO) reductase regulates novel endogenous S-nitrosothiol signaling pathways, and mice deficient in GSNO reductase are protected from airways hyperreactivity. S-nitrosothiols are present in the airway, and patients with cystic fibrosis (CF) tend to have low S-nitrosothiol levels that may be attributed to upregulation of GSNO ...
Khalequz Zaman, Victoria Sawczak, Atiya Zaidi, Maya Butler, Deric Bennett, Paulina Getsy, Maryam Zeinomar, Zivi Greenberg, Michael Forbes, Shagufta Rehman, Vinod Jyothikumar, Kim DeRonde, Abdus Sattar, Laura Smith, Deborah Corey, Adam Straub, Fei Sun, Lisa Palmer, Ammasi Periasamy, Scott Randell, Thomas J. Kelley, Stephen J. Lewis, Benjamin Gaston   +22 more
openaire   +3 more sources

S-Nitrosoglutathione Reductase (GSNOR) Deficiency Results in Secondary Hypogonadism [PDF]

The Journal of Sexual Medicine, 2018
AbstractBackgroundExcess reactive oxygen species and reactive nitrogen species are implicated in male infertility and impaired spermatogenesis.AimTo investigate the effect of excess reactive nitrogen species and nitrosative stress on testicular function and the hypothalamic-pituitary-gonadal axis using the S-nitrosoglutathione reductase-null (Gsnor−/−)
Thomas A, Masterson, Himanshu, Arora, Shathiyah, Kulandavelu, Rona S, Carroll, Ursula B, Kaiser, Sakir H, Gultekin, Joshua M, Hare, Ranjith, Ramasamy   +7 more
openaire   +3 more sources

Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase [PDF]

Circulation, 2019
Background: The biological effects of nitric oxide are mediated via protein S-nitrosylation. Levels of S-nitrosylated protein are controlled in part by the denitrosylase, S-nitrosoglutathione reductase (GSNOR). The objective of this study was to examine whether GSNOR inhibition improves outcomes after cardiac arrest and ...
Kei, Hayashida, Aranya, Bagchi, Yusuke, Miyazaki, Shuichi, Hirai, Divya, Seth, Michael G, Silverman, Emanuele, Rezoagli, Eizo, Marutani, Naohiro, Mori, Aurora, Magliocca, Xiaowen, Liu, Lorenzo, Berra, Allyson G, Hindle, Michael W, Donnino, Rajeev, Malhotra, Matthews O, Bradley, Jonathan S, Stamler, Fumito, Ichinose   +17 more
openaire   +3 more sources

Synergistic Intra‐ and Inter‐Nanozyme Electron Transfer through Interfacial Assembly for Enhanced Multi‐Enzyme Activity

Advanced Science
Prussian Blue composite nanozymes (PB C‐NZs) have been extensively employed in various biomedical applications. However, due to the complexity of its multi‐enzyme activities and structural components, designing material composition and processes ...
Kun Lu, Jizi Liu, Xiaoyang Zhu, Yu Mao, Hongliang He, Pingqiang Cai, Yan Li, Ning Gu   +7 more
doaj   +2 more sources

S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1 [PDF]

Nature Communications
Age-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood.
Xinhua Qiao, Ting Xie, Yuying Zhang, Chuanxin Sun, Xuanhao Wu, Yuzhe Chen, Qin Yao, Haoyang Shi, Shilong Li, Hongyu Zhao, Tiepeng Wang, Jiao Meng, Li Zhou, Mutian Niu, Yangxi Hu, Hansong Liu, Chang Chen   +16 more
doaj   +2 more sources

GSNOR Contributes to Demethylation and Expression of Transposable Elements and Stress-Responsive Genes

Antioxidants, 2021
In the past, reactive nitrogen species (RNS) were supposed to be stress-induced by-products of disturbed metabolism that cause oxidative damage to biomolecules.
Eva Esther Rudolf, Patrick Hüther, Ignasi Forné, Elisabeth Georgii, Yongtao Han, Rüdiger Hell, Markus Wirtz, Axel Imhof, Claude Becker, Jörg Durner, Christian Lindermayr   +10 more
doaj   +1 more source

Regulation of B cell functions by S-nitrosoglutathione in the EAE model

Redox Biology, 2021
B cells play both protective and pathogenic roles in T cell-mediated autoimmune diseases by releasing regulatory vs. pathogenic cytokines. B cell-depleting therapy has been attempted in various autoimmune diseases but its efficacy varies and can even ...
Judong Kim, S.M. Touhidul Islam, Fei Qiao, Avtar K. Singh, Mushfiquddin Khan, Jeseong Won, Inderjit Singh   +6 more
doaj   +1 more source

Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase [PDF]

Journal of Biological Chemistry, 2008
Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics.
Bateman, R., Rauh, D., Tavshanjian, B., Shokat, K.   +3 more
openaire   +3 more sources

Analysis of NIA and GSNOR family genes and nitric oxide homeostasis in response to wheat-leaf rust interaction

Scientific Reports, 2022
Nitric oxide (NO) modulates plant response to biotic and abiotic stresses by S-nitrosylation-mediated protein post-translational modification. Nitrate reductase (NR) and S-nitrosoglutathione reductase (GSNOR) enzymes are essential for NO synthesis and ...
Deepak T. Hurali, Ramesh Bhurta, Sandhya Tyagi, Lekshmy Sathee, Adavi B. Sandeep, Dalveer Singh, Niharika Mallick, Vinod, Shailendra K. Jha   +8 more
doaj   +1 more source