Results 41 to 50 of about 2,423 (153)

Increased Nitrosoglutathione Reductase Activity in Hypoxic Pulmonary Hypertension in Mice

Journal of Pharmacological Sciences, 2010
Altered S-nitrosothiols (RSNO) signaling is linked to pulmonary hypertension. Recent studies have shown that S-nitrosoglutathione (GSNO) reductase (GSNOR) catalyzes the degradation of GSNO and indirectly regulates the level of RSNO in vivo.
Xiling Wu, Lizhong Du, Xuefeng Xu, Linhua Tan, Ruyi Li   +4 more
doaj   +1 more source

Kinetic and Cellular Characterization of Novel Inhibitors of S-Nitrosoglutathione Reductase [PDF]

Journal of Biological Chemistry, 2009
S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have shown that GSNOR regulates the smooth muscle tone in airways and the function of beta-adrenergic receptors in lungs and heart.
Paresh C, Sanghani, Wilhelmina I, Davis, Sharry L, Fears, Scheri-Lyn, Green, Lanmin, Zhai, Yaoping, Tang, Emil, Martin, Nathan S, Bryan, Sonal P, Sanghani   +8 more
openaire   +2 more sources

Nitric Oxide-induced Protein S-nitrosylation Causes Mitochondrial Dysfunction and Accelerates Post-ovulatory Aging of Oocytes in Cattle

Journal of Animal Reproduction and Biotechnology, 2020
Nitric oxide (NO)-induced protein S-nitrosylation triggers mitochondrial dysfunction and was related to cell senescence. However, the exact mechanism of these damages is not clear.
Ying-Jie Niu, Dongjie Zhou, Wenjun Zhou, Zheng-Wen Nie, Ju-Yeon Kim, YoungJin Oh, So-Rim Lee, Xiang-Shun Cui   +7 more
doaj   +1 more source

Response to Antimony Toxicity in Dittrichia viscosa Plants: ROS, NO, H₂S, and the Antioxidant System

Antioxidants, 2021
Dittrichia viscosa plants were grown hydroponically with different concentrations of Sb. There was preferential accumulation of Sb in roots. Fe and Cu decreased, while Mn decreased in roots but not in leaves.
Francisco Luis Espinosa-Vellarino, Inmaculada Garrido, Alfonso Ortega, Ilda Casimiro, Francisco Espinosa   +4 more
doaj   +1 more source

Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor

Journal of Cardiovascular Pharmacology and Therapeutics, 2016
Background and Purpose: Published data on nebivolol reveal selective β1 adrenergic selectively along with novel nitric oxide (NO)-dependent vasodilatory properties. However, the exact molecular mechanism is unknown.
Hong, Jiang, David J, Polhemus, Kazi N, Islam, Ashley C, Torregrossa, Zhen, Li, Amy, Potts, David J, Lefer, Nathan S, Bryan   +7 more
openaire   +2 more sources

GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation

Redox Biology, 2021
Innate immunity is the first line of host defense against pathogens. This process is modulated by multiple antiviral protein modifications, such as phosphorylation and ubiquitination.
Qianjin Liu, Tianle Gu, Ling-Yan Su, Lijin Jiao, Xinhua Qiao, Min Xu, Ting Xie, Lu-Xiu Yang, Dandan Yu, Ling Xu, Chang Chen, Yong-Gang Yao   +11 more
doaj   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source

Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration

Cell Reports, 2021
Summary: Hematopoietic stem cells (HSCs) regenerate blood cells upon hematopoietic injuries. During homeostasis, HSCs are maintained in a low reactive oxygen species (ROS) state to prevent exhaustion. However, the role of nitric oxide (NO) in controlling
Weiwei Yi, Yuying Zhang, Bo Liu, Yuanyuan Zhou, Dandan Liao, Xinhua Qiao, Dan Gao, Ting Xie, Qin Yao, Yao Zhang, Yugang Qiu, Gang Huang, Zhiyang Chen, Chang Chen, Zhenyu Ju   +14 more
doaj   +1 more source

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S‐Nitrosylation of MEK1

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3656-3678, June 2026.
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao   +12 more
wiley   +1 more source

ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

Cell Reports, 2021
Summary: Brown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status, but the underlying molecular mechanisms are incompletely understood.
Sara C. Sebag, Zeyuan Zhang, Qingwen Qian, Mark Li, Zhiyong Zhu, Mikako Harata, Wenxian Li, Leonid V. Zingman, Limin Liu, Vitor A. Lira, Matthew J. Potthoff, Alexander Bartelt, Ling Yang   +12 more
doaj   +1 more source