Results 61 to 70 of about 2,423 (153)

Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5

FASEB BioAdvances, Volume 7, Issue 12, December 2025.
Exogenous formate administration reduces myocardial ischemic injury in intact alcohol dehydrogenase 5 knockout (ADH5−/−) female mice, but not in intact or ovariectomized wild‐type female mice. One‐carbon metabolism may play an intermediate role. This graphic was generated using BioRender.
Haley Garbus‐Grant, Obialunanma V. Ebenebe‐Kasonde, Raihan Kabir, Mark J. Kohr   +3 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, Volume 58, Issue 11, November 2025.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Phytoglobin Scavenging of Nitric Oxide Is Associated With Ethylene Reduction and Drought Tolerance in Oat (Avena sativa)

Physiologia Plantarum, Volume 177, Issue 6, November/December 2025.
ABSTRACT Drought stress significantly impacts crop productivity and plant physiology. Nitric oxide (NO) signalling is essential for drought tolerance. This study explores the relationship between in vivo NO levels, mediated by NO scavenging phytoglobin (encoded by Pgb, non‐symbiosis associated hemoglobin), and drought tolerance in oat (Avena sativa ...
Gracia Montilla‐Bascon, Simona M. Cristescu, Luis A. J. Mur, Elena Prats   +3 more
wiley   +1 more source

The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis

BioEssays, Volume 47, Issue 10, October 2025.
This review highlights the dynamic interplay between nitric oxide (NO) and reactive oxygen species (ROS) in regulating plant stem cell renewal and differentiation. NO and ROS integrate intrinsic factors like epigenetic and hormonal signals with extrinsic cues, including environmental stress and nutrient‐TOR signaling, to maintain meristem function and ...
Jian Zeng, Xin'Ai Zhao, Jan U. Lohmann
wiley   +1 more source

ROS-mediated inhibition of S-nitrosoglutathione reductase contributes to the activation of anti-oxidative mechanisms

Frontiers in Plant Science, 2016
Nitric oxide (NO) has emerged as a signaling molecule in plants being involved in diverse physiological processes like germination, root growth, stomata closing and response to biotic and abiotic stress.
Izabella Kovacs, Christian Holzmeister, Markus Wirtz, Arie Geerlof, Thomas Fröhlich, Gaby Römling, Gitto Thomas Kuruthukulangarakoola, Eric Linster, Ruediger Hell, Georg J. Arnold, Joerg Durner, Joerg Durner, Christian Lindermayr   +12 more
doaj   +1 more source

S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury

Cell Reports, 2014
Toxic liver injury is a leading cause of liver failure and death because of the organ’s inability to regenerate amidst massive cell death, and few therapeutic options exist.
Andrew G. Cox, Diane C. Saunders, Peter B. Kelsey Jr., Allie A. Conway, Yevgenia Tesmenitsky, Julio F. Marchini, Kristin K. Brown, Jonathan S. Stamler, Dorothy B. Colagiovanni, Gary J. Rosenthal, Kevin J. Croce, Trista E. North, Wolfram Goessling   +12 more
doaj   +1 more source

Functional Characterisation of Alternative Oxidase Protein Isoproteins in Arabidopsis thaliana

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT The Alternative Oxidase (AOX) is encoded by a small gene family in plants. While being one of the most intensively studied plant mitochondrial proteins, it is primarily only one isoform, AOX1a, that is well studied. We investigated the sub‐and neo‐functionalisation of AOX isoforms in Arabidopsis thaliana by constructing over‐expressing lines ...
Cunman He, Andreas Hartmann, Minxuan Li, Yanqiao Zhu, Reena Narsai, Kemeng Xiao, Kun Qian, Oliver Berkowitz, Jennifer Selinski, James Whelan   +9 more
wiley   +1 more source

Meta‐Analysis of Iron Excess Stress in Rice: Genes and Mechanisms of Tolerance to Acidic Soil

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT Iron toxicity, predominantly stemming from excessive levels of ferrous iron (Fe2+) in acidic soils, poses a considerable challenge for crop production. Hypoxic conditions induced by waterlogging can exacerbate Fe2+ availability, which significantly impacts the cultivation and productivity of rice (Oryza sativa), a staple food for millions ...
Divya Gupta, Sanjib Kumar Panda, Petra Bauer   +2 more
wiley   +1 more source

Two Subunits of the Rpd3 Histone Deacetylase Complex of Cochliobolus heterostrophus Are Essential for Nitrosative Stress Response and Virulence, and Interact With Stress‐Response Regulators ChHog1 and ChCrz1

Molecular Plant Pathology, Volume 26, Issue 8, August 2025.
ChPho23 and ChSds3, two components of the Rpd3 histone deacetylase complex associated with ChHog1, regulate the transcription factor ChCrz1 and modulate the nitrosative stress response and virulence in Cochliobolus heterostrophus. ABSTRACT Southern corn leaf blight (SCLB), caused by Cochliobolus heterostrophus, is a destructive disease in maize‐growing
Jinyu Fan, Jun Hu, Dan Li, Yuanyuan Tian, Mengjiao Jia, Tianye Liang, Hongyu Pan, Xianghui Zhang   +7 more
wiley   +1 more source

Production and scavenging of reactive oxygen species in plant cells under cadmium stress

Agronomy Journal, Volume 117, Issue 4, July/August 2025.
Abstract Cadmium (Cd) causes the excessive accumulation of reactive oxygen species (ROS) in plant cells, inhibits plant growth, and reduces crop productivity (e.g., grain yields). However, our understanding of Cd migration, ROS accumulation, and the underlying mechanisms in plant cells remains limited.
Ying Hu, Huichun Wang
wiley   +1 more source