Results 31 to 40 of about 1,125 (150)

GSNOR deletion differentially alters age-related cardiac function in a sex-dependent manner. [PDF]

Am J Physiol Heart Circ Physiol
GSNOR deficiency appears beneficial to cardiac aging in both sexes, but at the cellular level, we discovered a sex disparity and the potential for underlying cellular dysfunction in female hearts. Taken together, GSNOR deficiency may present a mechanism through which the female heart specifically is at a higher risk of age-related cardiovascular ...
Ebenebe OV, Kabir R, Booher A, Garbus H, Cohen CD, Jani V, Lin BL, Adamo L, Kohr MJ.   +8 more
europepmc   +3 more sources

The role of S-nitrosoglutathione reductase (GSNOR) in T cell-mediated immunopathology of experimental autoimmune encephalomyelitis (EAE) [PDF]

Neuroscience
Judong Kim, Inderjit Singh, Je-Seong Won   +2 more
exaly   +2 more sources

GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation

Redox Biology, 2018
The adaptive immune system plays a critical role in hyperhomocysteinemia (HHcy)-accelerated atherosclerosis. Recent studies suggest that HHcy aggravates atherosclerosis with elevated oxidative stress and reduced S-nitrosylation level of redox-sensitive ...
Jing Li, Yan Zhang, Yuying Zhang, Silin Lü, Yutong Miao, Juan Yang, Shenming Huang, Xiaolong Ma, Lulu Han, Jiacheng Deng, Fangfang Fan, Bo Liu, Yong Huo, Qingbo Xu, Chang Chen, Xian Wang, Juan Feng   +16 more
doaj   +1 more source

Efficacies of S-nitrosoglutathione (GSNO) and GSNO reductase inhibitor in SARS-CoV-2 spike protein induced acute lung disease in mice

Frontiers in Pharmacology, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially surfaced in late 2019, often triggers severe pulmonary complications, encompassing various disease mechanisms such as intense lung inflammation, vascular dysfunction, and ...
Judong Kim, Fei Qiao, Avtar K. Singh, Avtar K. Singh, Jeseong Won, Inderjit Singh, Inderjit Singh   +6 more
doaj   +1 more source

GSNOR regulates ganoderic acid content in Ganoderma lucidum under heat stress through S-nitrosylation of catalase

Communications Biology, 2022
Liu et al. identify catalase as a target of S-nitrosylation by GSNOR and the specific sites of S-nitrosylation critical for its role in regulating secondary metabolite production in Ganoderma lucidum under heat stress.
Rui Liu, Ting Zhu, Xin Chen, Zi Wang, Zhengyan Yang, Ang Ren, Liang Shi, Hanshou Yu, Mingwen Zhao   +8 more
doaj   +1 more source

ROS-mediated inhibition of S-nitrosoglutathione reductase contributes to the activation of anti-oxidative mechanisms

Frontiers in Plant Science, 2016
Nitric oxide (NO) has emerged as a signaling molecule in plants being involved in diverse physiological processes like germination, root growth, stomata closing and response to biotic and abiotic stress.
Izabella Kovacs, Christian Holzmeister, Markus Wirtz, Arie Geerlof, Thomas Fröhlich, Gaby Römling, Gitto Thomas Kuruthukulangarakoola, Eric Linster, Ruediger Hell, Georg J. Arnold, Joerg Durner, Joerg Durner, Christian Lindermayr   +12 more
doaj   +1 more source

Quantitative Proteome Profiling of a S-Nitrosoglutathione Reductase (GSNOR) Null Mutant Reveals a New Class of Enzymes Involved in Nitric Oxide Homeostasis in Plants

Frontiers in Plant Science, 2021
Nitric oxide (NO) is a short-lived radical gas that acts as a signaling molecule in all higher organisms, and that is involved in multiple plant processes, including germination, root growth, and fertility.
Patrick Treffon, Jacopo Rossi, Giuseppe Gabellini, Paolo Trost, Mirko Zaffagnini, Elizabeth Vierling   +5 more
doaj   +1 more source

Regulation of B cell functions by S-nitrosoglutathione in the EAE model

Redox Biology, 2021
B cells play both protective and pathogenic roles in T cell-mediated autoimmune diseases by releasing regulatory vs. pathogenic cytokines. B cell-depleting therapy has been attempted in various autoimmune diseases but its efficacy varies and can even ...
Judong Kim, S.M. Touhidul Islam, Fei Qiao, Avtar K. Singh, Mushfiquddin Khan, Jeseong Won, Inderjit Singh   +6 more
doaj   +1 more source

Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma [PDF]

Biochemical Pharmacology, 2019
Abstract The denitrosylating enzyme S- nitrosoglutathione reductase (GSNOR), has been reported to control the selective degradation of mitochondria through mitophagy, by modulating the extent of nitric oxide-modified proteins ( S- nitrosylation ...
Rizza, Salvatore, Di Leo, Luca, Mandatori, Sara, De Zio, Daniela, Filomeni, Giuseppe   +4 more
openaire   +4 more sources

Unravelling GSNOR-Mediated S-Nitrosylation and Multiple Developmental Programs in Tomato Plants [PDF]

Plant and Cell Physiology, 2019
Abstract Nitric oxide (NO) impacts multiple developmental events and stress responses in plants. S-nitrosylation, regulated by S-nitrosoglutathione reductase (GSNOR), is considered as an important route for NO bioactivity. However, genetic evidence for GSNOR-mediated plant development and S-nitrosylation remains elusive in crop species ...
Biao Gong, Yanyan Yan, Lili Zhang, Fei Cheng, Zhen Liu, Qinghua Shi   +5 more
openaire   +2 more sources