S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension [PDF]
Redox Biology, 2019 Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation ...
Yuying Zhang, Nanping Wang, Lei Xiao
exaly +4 more sources
ESNOQ, proteomic quantification of endogenous S-nitrosation. [PDF]
PLoS ONE, 2010 S-nitrosation is a post-translational protein modification and is one of the most important mechanisms of NO signaling. Endogenous S-nitrosothiol (SNO) quantification is a challenge for detailed functional studies.
Xixi Zhou +6 more
doaj +3 more sources
Oxygen-linked S-nitrosation in fish myoglobins: a cysteine-specific tertiary allosteric effect. [PDF]
PLoS ONE, 2014 The discovery that cysteine (Cys) S-nitrosation of trout myoglobin (Mb) increases heme O2 affinity has revealed a novel allosteric effect that may promote hypoxia-induced nitric oxide (NO) delivery in the trout heart and improve myocardial efficiency. To
Signe Helbo +5 more
doaj +3 more sources
S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory [PDF]
Redox BiologyCa2+/calmodulin-dependent protein kinase II α (CaMKIIα) and nitric oxide (NO) both play vital roles in learning and memory; however, the underlying mechanisms connecting them have remained elusive.
Boyu Chu +13 more
doaj +2 more sources
S-Nitrosoglutathione Reductase—The Master Regulator of Protein S-Nitrosation in Plant NO Signaling
Plants, 2019 S-nitrosation has been recognized as an important mechanism of protein posttranslational regulations, based on the attachment of a nitroso group to cysteine thiols.
Jana Jahnová +2 more
exaly +3 more sources
S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis
Frontiers in Plant Science, 2022 E3 ubiquitin ligases mediate the last step of the ubiquitination pathway in the ubiquitin-proteasome system (UPS). By targeting transcriptional regulators for their turnover, E3s play a crucial role in every aspect of plant biology.
Maria Cecilia Terrile +15 more
doaj +1 more source
Antioxidants, 2022 Nitric oxide (NO) is a free radical with a signaling capacity. Its cellular functions are achieved mainly through S-nitrosation where thioredoxin (hTrx) is pivotal in the S-transnitrosation to specific cellular targets.
Vitor S. Almeida +6 more
doaj +1 more source
Nitric oxide destabilizes Pias3 and regulates sumoylation. [PDF]
PLoS ONE, 2007 Small ubiquitin-related protein modifiers (SUMO) modification is an important mechanism for posttranslational regulation of protein function. However, it is largely unknown how the sumoylation pathway is regulated.
Jing Qu +7 more
doaj +1 more source
NO and Heme Proteins: Cross-Talk between Heme and Cysteine Residues
Antioxidants, 2023 Heme proteins are a diverse group that includes several unrelated families. Their biological function is mainly associated with the reactivity of the heme group, which—among several other reactions—can bind to and react with nitric oxide (NO) and other ...
Cinzia Verde +2 more
doaj +1 more source
Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells
Redox Biology, 2020 Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized.
Aleksandra Kopacz +11 more
doaj +1 more source