Results 21 to 30 of about 4,880 (161)
Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols
Redox Biology, 2022 Nitrosation of critical thiols has been elaborated as reversible posttranslational modification with regulatory function in multiple disorders. Reversibility of S-nitrosation is generally associated with enzyme-mediated one-electron reductions, catalyzed
Stefan Schildknecht +5 more
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Nitric oxide destabilizes Pias3 and regulates sumoylation. [PDF]
PLoS ONE, 2007 Small ubiquitin-related protein modifiers (SUMO) modification is an important mechanism for posttranslational regulation of protein function. However, it is largely unknown how the sumoylation pathway is regulated.
Jing Qu +7 more
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Redox Biology, 2022 Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential for cardiovascular homeostasis but is disrupted by oxidative stress, which causes GC1 desensitization to NO by ...
Chuanlong Cui +5 more
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S-Nitrosation: Current Concepts and New Developments [PDF]
Antioxidants & Redox Signaling, 2012 The S-nitrosation (also referred to as S-nitrosylation) of cysteine residues is an important post-translational protein modification that regulates protein function and cell signaling. The original research articles and reviews in this Forum cover important concepts in protein S-nitrosation and identify key developments and opportunities for progress ...
Douglas D, Thomas, David, Jourd'heuil
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Novel Tocolytic Strategy: Modulating Cx43 Activity by <i>S</i>-Nitrosation. [PDF]
J Pharmacol Exp Ther, 2021 Currently available tocolytics are ineffective at significantly delaying preterm birth. This is due in part to our failure to better understand the mechanisms that drive spontaneous preterm labor (sPTL). Cyclic nucleotides are not the primary contributors to myometrial quiescence, but instead nitric oxide (NO)-mediated protein S-nitrosation (SNO) is ...
Barnett SD +3 more
europepmc +4 more sources
Detailed mechanistic investigation into the S-nitrosation of cysteamine [PDF]
Canadian Journal of Chemistry, 2012 The nitrosation of cysteamine (H2NCH2CH2SH) to produce cysteamine-S-nitrosothiol (CANO) was studied in slightly acidic medium by using nitrous acid prepared in situ. The stoichiometry of the reaction was H2NCH2CH2SH + HNO2 → H2NCH2CH2SNO + H2O.
Moshood K, Morakinyo +7 more
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Antioxidants, 2022 Protein cysteines (Cys) undergo a multitude of different reactive oxygen species (ROS), reactive sulfur species (RSS), and/or reactive nitrogen species (RNS)-derived modifications.
Patrick Treffon, Elizabeth Vierling
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S-Nitrosation of Cellular Proteins by NO Donors in Rat Embryonic Fibroblast 3Y1 Cells: Factors Affecting S-Nitrosation [PDF]
Oxidative Medicine and Cellular Longevity, 2011 The mechanism of protein S-nitrosation in cells is not fully understood. Using rat 3Y1 cells, we addressed this issue. Among S-nitrosothiols and NO donors tested, only S-nitrosocysteine (CysNO) induced S-nitrosation when exposed in Hanks' balanced salt solution (HBSS) and not in serum-containing general culture medium.
Ryuman, Norihiro +2 more
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HIF‐1α protein as a target for S‐nitrosation
FEBS Letters, 2003 Hypoxia‐inducible factor‐1α (HIF‐1α) is a master regulator to sense decreased oxygen partial pressure. HIF‐1α stability regulation initiates a complex biological response that allows cells to act appropriately to meet patho‐physiological situations of decreased oxygen availability.
Sumbayev, Vadim V +3 more
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Biomolecules, 2019 S-nitrosoglutathione reductase (GSNOR) exerts crucial roles in the homeostasis of nitric oxide (NO) and reactive nitrogen species (RNS) in plant cells through indirect control of S-nitrosation, an important protein post-translational modification in ...
Tereza Jedelská +5 more
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