Results 61 to 70 of about 7,232 (217)

Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases

Antioxidants
Cardiovascular diseases (CVDs) are often associated with impaired nitric oxide (NO) bioavailability, a critical pathophysiological alteration in CVDs and an important target for therapeutic interventions.
Mila Silva-Cunha, Riccardo Lacchini, Jose E. Tanus-Santos   +2 more
doaj   +1 more source

Plant catalases as NO and H2S targets

Redox Biology, 2020
Catalase is a powerful antioxidant metalloenzyme located in peroxisomes which also plays a central role in signaling processes under physiological and adverse situations. Whereas animals contain a single catalase gene, in plants this enzyme is encoded by
José M. Palma, Rosa M. Mateos, Javier López-Jaramillo, Marta Rodríguez-Ruiz, Salvador González-Gordo, Alfonso M. Lechuga-Sancho, Francisco J. Corpas   +6 more
doaj   +1 more source

Focus on Nitric Oxide Homeostasis: Direct and Indirect Enzymatic Regulation of Protein Denitrosation Reactions in Plants

Antioxidants, 2022
Protein cysteines (Cys) undergo a multitude of different reactive oxygen species (ROS), reactive sulfur species (RSS), and/or reactive nitrogen species (RNS)-derived modifications.
Patrick Treffon, Elizabeth Vierling
doaj   +1 more source

A Robust and Universal LC–MS/MS Method for Determination of N‐Nitrosodimethylamine in Pharmaceuticals Using a C30 Column

Journal of Separation Science, Volume 49, Issue 6, June 2026.
ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An, Unyong Kim, Sumin Seo, Jiyu Kim, Chohee Jeong, Woojin Jeong, Eunjin Ko, Juhyeon Kim, Hyun‐Deok Cho, Sang Beom Han   +9 more
wiley   +1 more source

S-Nitrosoglutathione Inactivation of the Mitochondrial and Cytosolic BCAT Proteins: S-nitrosation and S-thiolation [PDF]

, 2009
Specific proteins with reactive thiol(ate) groups are susceptible to nitric oxide (NO) modification, which can result in S-nitrosation, S-thiolation, or disulfide bond formation.
Hutson, Susan M., Conway, Myra E., Sharrod, Hayley, Hancock, John T., Patel, V.B., Coles, Steven, Easton, Peter, Patel, VB, Easton, P., Sharrod, H., Conway, M.E., Coles, Steven J., Hancock, J.T., Patel, V., Coles, S.J., Hutson, S.M., Patel, Vinood B., Hancock, J.   +17 more
core   +1 more source

Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang, Hong Huang, Jin Lin, Yanan Niu, Jiaxin Chen, Jiaxuan Tang, Zhengyuan Hu, Peng Liu, Jun Qu   +8 more
wiley   +1 more source

Red meat and colon cancer : should we become vegetarians, or can we make meat safer ? [PDF]

, 2011
The effect of meat consumption on cancer risk is a controversial issue. However, recent meta-analyses show that high consumers of cured meats and red meat are at increased risk of colorectal cancer.
Denis E. Corpet, Corpet, Denis, Corpet, Denis E.   +2 more
core   +1 more source

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S‐Nitrosylation of MEK1

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3656-3678, June 2026.
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao   +12 more
wiley   +1 more source

Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes [PDF]

, 2018
Cysteine S-nitrosation is a reversible post-translational modification mediated by nitric oxide (•NO)-derived agents. S-Nitrosation participates in cellular signaling and is associated with several diseases such as cancer, cardiovascular diseases, and ...
Sarah L. Wynia-Smith, Wynia-Smith, Sarah L, Marletta, Michael A, Smith, Brian C, Joel J. Bruegger, Bruegger, Joel J, Brian C. Smith, Michael A. Marletta   +7 more
core   +1 more source

The first example of the Fischer–Hepp type rearrangement in pyrimidines

Beilstein Journal of Organic Chemistry, 2013
A N-nitroso moiety can be used for the activation of chloropyrimidines toward a nucleophilic substitution reaction with amines. The subsequent treatment of the obtained products with aq H2SO4 can lead to either N-denitrosation to obtain 4,6 ...
Inga Cikotiene, Mantas Jonusis, Virginija Jakubkiene   +2 more
doaj   +1 more source