Results 131 to 140 of about 4,320,383 (194)

Repeated endosulfan exposure induces changes in neurochemicals, decreases ATPase transmembrane ionic-pumps, and increased oxidative/nitrosative stress in the brains of rats: Reversal by quercetin.

Pesticide Biochemistry and Physiology, 2021
Neurochemical and ATPase deregulations play important role in toxicant-induced neurodegeneration. Previous studies have shown that loss of ATPase ionic-pumps alters neurochemical balance via increased ammonia, oxidative and nitrosative stress. Thus, this
M. O. Oyovwi, B. Ben-Azu, E. Tesi, A. A. Oyeleke, C. Uruaka, R. A. Rotu, Eneni Okubo Aya-Ebi   +6 more
semanticscholar   +1 more source

Therapeutic Targets of Oxidative/Nitrosative Stress and Neuroinflammation in Ischemic Stroke: Applications for Natural Product Efficacy with Omics and Systemic Biology.

Pharmacological Research, 2020
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal damage, blood-brain barrier (BBB) damage and hemorrhagic transformation (HT ...
Hansen Chen, Yacong He, Shuang Chen, Su‐Hua Qi, Jiangang Shen   +4 more
semanticscholar   +1 more source

Nitrosative stress in cancer therapy

Frontiers in Bioscience, 2007
Reactive nitrogen species play important roles in cell signalling, but when present at high concentrations they can subject cells to nitrosative stress, which may lead to cell death. Nitric oxide (NOx) is now recognized as playing important roles in cancer aetiology and progression and it can influence the outcome of cancer treatment. It is synthesised
Hirst, David, Robson, Tracy
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Handling Nitrosative Stress

Science Signaling, 2012
Bacteria adapting to growth in the presence of nitrate activate a transcriptional regulator also involved in oxidative stress.
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Oxidative-Nitrosative Stress In Hypertension

Current Vascular Pharmacology, 2005
Reactive oxygen species (ROS) are important signaling molecules in the vasculature. However, when there is imbalance between their occurrence and antioxidant defense mechanisms, ROS can contribute to the vascular abnormalities that lead to hypertension.
Nelson, Escobales, Maria J, Crespo
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Nitrosative Stress and Transcription

Biological Chemistry, 2003
Low NO concentrations synthesized by constitutively expressed NO synthases act on several signaling pathways activating transcription factors (TF), such as NF-kappaB or AP-1, and thereby influence gene expression. In contrast, during inflammatory reactions the inducible NO synthase produces NO for prolonged periods of time.
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Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review.

Neuroscience, 2019
The global burden of neurodegenerative disorders has increased substantially over the past 2 decades due to rising rates of population aging. Although neurodegenerative disorders differ in their clinical presentation, the underlying pathobiological ...
Shameemah Abrahams, William Haylett, G. Johnson, J. Carr, S. Bardien   +4 more
semanticscholar   +1 more source

Lipopolysaccharide-Induced Depression-Like Behaviors Is Ameliorated by Sodium Butyrate via Inhibiting Neuroinflammation and Oxido-Nitrosative Stress

Pharmacology, 2020
Depression is a common disease that afflicts one in 6 people. Numerous hypotheses have been raised in the past decades, but the exact mechanism for depression onset remains obscure.
J. Qiu, Renjie Liu, Yaoying Ma, Yan Li, Zhuo Chen, Haiyan He, Jinliang Chen, Lijuan Tong, Chao Huang, Q. You   +9 more
semanticscholar   +1 more source

Hepatic nitrosative stress in experimental diabetes

Journal of Diabetes and its Complications, 2012
The effects of the inhibition of nitrosative stress by aminoguanidine in an experimental model of diabetes mellitus (DM) were investigated.Twenty-one male Wistar rats were divided into three groups: control (CO), diabetic (DM), and diabetic treated with aminoguanidine (DM+AG).
Fábio Cangeri, Di Naso, Graziella, Rodrigues, Alexandre, Simões Dias, Marilene, Porawski, Henrique, Fillmann, Norma Possa, Marroni   +5 more
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Stress nitrosant et pathologies

Revue Francophone des Laboratoires, 2020
Resume Le monoxyde d’azote (NO.) est un important messager intracellulaire produit par les NO-synthases (NOS). Il existe trois isoformes de NOS : neuronale, endotheliale et inductible. De nombreuses fonctions physiologiques et pathologiques du NO. ont ete rapportees.
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