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Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia.
Am J Physiol Lung Cell Mol PhysiolGaston B +9 more
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A Genetic Analysis of Nitrosative Stress
Biochemistry, 2009Nitrosative stress is induced by pathophysiological levels of nitric oxide (NO) and S-nitrosothiols (e.g., S-nitrosoglutathione, GSNO) and arises, at least in significant part, from the nitrosylation of critical protein Cys thiols (S-nitrosylation) and metallocofactors.
Matthew W, Foster +4 more
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Nitrosative stress in cancer therapy
Frontiers in Bioscience, 2007Reactive nitrogen species play important roles in cell signalling, but when present at high concentrations they can subject cells to nitrosative stress, which may lead to cell death. Nitric oxide (NOx) is now recognized as playing important roles in cancer aetiology and progression and it can influence the outcome of cancer treatment. It is synthesised
Hirst, David, Robson, Tracy
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An Apoptotic Model for Nitrosative Stress
Biochemistry, 2000Nitric oxide overproduction has been implicated in the pathogenesis of many disorders, including artherosclerosis, neurodegenerative diseases, inflammatory and autoimmune diseases, and cancer. The common view holds that nitric oxide-induced cellular injury is caused by oxidative stress.
J P, Eu, L, Liu, M, Zeng, J S, Stamler
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Oxidative-Nitrosative Stress In Hypertension
Current Vascular Pharmacology, 2005Reactive oxygen species (ROS) are important signaling molecules in the vasculature. However, when there is imbalance between their occurrence and antioxidant defense mechanisms, ROS can contribute to the vascular abnormalities that lead to hypertension.
Nelson, Escobales, Maria J, Crespo
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Nitrosative Stress and Transcription
Biological Chemistry, 2003Low NO concentrations synthesized by constitutively expressed NO synthases act on several signaling pathways activating transcription factors (TF), such as NF-kappaB or AP-1, and thereby influence gene expression. In contrast, during inflammatory reactions the inducible NO synthase produces NO for prolonged periods of time.
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Science Signaling, 2012
Bacteria adapting to growth in the presence of nitrate activate a transcriptional regulator also involved in oxidative stress.
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Bacteria adapting to growth in the presence of nitrate activate a transcriptional regulator also involved in oxidative stress.
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Oxidative and nitrosative stress in ammonia neurotoxicity
Neurochemistry International, 2013Increased ammonia accumulation in the brain due to liver dysfunction is a major contributor to the pathogenesis of hepatic encephalopathy (HE). Fatal outcome of rapidly progressing (acute) HE is mainly related to cytotoxic brain edema associated with astrocytic swelling.
Marta, Skowrońska, Jan, Albrecht
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Oxidative Stress and Nitrosative Stress
2016Cardiomyocytes generate multiple forms of short half-life molecules known as reactive oxygen and reactive nitrogen species (ROS) and acting as signaling molecules (RNS). However, under certain conditions the balance between formation of oxygen radicals and degradation of them is severely affected resulting in oxidative stress that significantly ...
Rainer Schulz, Fabio Di Lisa
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Need of biomarkers of nitrosative stress in plants
Trends in Plant Science, 2007Reactive oxygen species (ROS) and oxidative stress are well recognized terms in plant physiology and biochemistry [1]. However, the same is not true for the terms reactive nitrogen species (RNS) and nitrosative stress, despite the fact that the gaseous radical nitric oxide ( NO) is one of the molecules that has attracted most attention from plant ...
Francisco J, Corpas +2 more
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