Results 161 to 170 of about 25,127 (201)
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Hepatic nitrosative stress in experimental diabetes
Journal of Diabetes and its Complications, 2012The effects of the inhibition of nitrosative stress by aminoguanidine in an experimental model of diabetes mellitus (DM) were investigated.Twenty-one male Wistar rats were divided into three groups: control (CO), diabetic (DM), and diabetic treated with aminoguanidine (DM+AG).
Fábio Cangeri, Di Naso +5 more
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Oxidative and Nitrosative Stress
2017Oxidative stress plays a critical role in the pathophysiology of stroke and results when there is a disruption of the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS), although critical for normal physiologic processes, are detrimental if produced in excess.
J.M. Modak, L.D. McCullough
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Radicals, Oxidative/Nitrosative Stress and Preeclampsia
Mini-Reviews in Medicinal Chemistry, 2019Preeclampsia (PE) has a profound effect in increasing both maternal and fetal morbidity and mortality especially in third World. Disturbances of extravillous trophoblast migration toward uterine spiral arteries is characteristic feature of PE, which, in turn, leads to increased uteroplacental vascular ...
Seyithan, Taysi +3 more
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Effects of oxidative and nitrosative stress in cytotoxicity
Seminars in Perinatology, 2000Nitric oxide is a key bioregulatory agent in a wide variety of biological processes, yet it also can have cytotoxic properties. This dichotomy raises the question of how this potentially toxic species can be involved in so many fundamental physiological processes.
D A, Wink, K M, Miranda, M G, Espey
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The response of Paracoccidioides spp. to nitrosative stress
Microbes and Infection, 2015Paracoccidioidomycosis (PCM) is an endemic disease in Latin America caused by species belonging to the genus Paracoccidioides. During infection, immune cells present a variety of defense mechanisms against pathogens. One of these defensive strategies is the production and release of nitric oxide (NO) and S-nitroso thiols (e.g., S-nitrosoglutathione ...
Ana F A, Parente +6 more
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Nitrosative Stress and Pathogenesis of Insulin Resistance
Antioxidants & Redox Signaling, 2006Insulin resistance is a major causative factor for type 2 diabetes and is associated with increased risk of cardiovascular disease. Despite intense investigation for a number of years, molecular mechanisms underlying insulin resistance remain to be determined.
Masao, Kaneki +3 more
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Oxidative modifications in nitrosative stress
Nature Structural Biology, 1998The molecular basis of redox sensitivity in proteins is not well understood. Here we consider a continuum of NO- and O2-related modifications of cysteine residues that constitute biological signaling events on the one hand and hallmarks of nitrosative and oxidative stresses on the other.
Jonathan S. Stamler, Alfred Hausladen
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Oxidative and nitrosative stress in the maintenance of myocardial function
Free Radical Biology and Medicine, 2012Reactive oxygen species (ROS) are generated by several different cellular sources, and their accumulation within the myocardium is widely considered to cause harmful oxidative stress. On the other hand, their role as second messengers has gradually emerged.
Zhang Y +3 more
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Oxidative and nitrosative stress in acute ischaemic stroke
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2007Background: Increased nitric oxide (NO) production may result in further brain damage via nitric oxide synthase uncoupling in patients with acute ischaemic stroke by increasing free radical formation and oxidative stress. In this connection, we measured nitrite and nitrate (NO metabolites), ischaemia-modified albumin (IMA) and thiobarbituric acid ...
Coşkun, ÖZLEM +5 more
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Nitrosative stress in an animal model of necrotizing enterocolitis
Free Radical Biology and Medicine, 2005Necrotizing enterocolitis (NEC) is a disease of newborns characterized by gut barrier failure. We reasoned that upregulation of inducible nitric oxide synthase (iNOS) may result in nitrosative stress and accumulation of nitroso species in the intestine. Newborn rats were either breast-fed (BF), or formula-fed and additionally subjected to hypoxia (FFH).
Zamora, Ruben +7 more
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