Results 31 to 40 of about 18,603 (231)
Biomolecules, 2015 Many inflammatory diseases have an oxidative aetiology, which leads to oxidative damage to biomolecules, including proteins. It is now increasingly recognized that oxidative post-translational modifications (oxPTMs) of proteins affect cell signalling and
Ivan Verrastro +4 more
doaj +1 more source
Effect of 17-DMAG on nitrotyrosine levels in the kidney. [PDF]
, 2012 (A) Western blot analysis of nitrotyrosine was performed with monoclonal antibodies in kidney homogenates. The bar graphs were mean±SE density values from proteins ≤50 kDa normalized to the db/db-HF-S group from 6 animals per group.
Chih-Ko Yeh (179145) +4 more
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Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection [PDF]
, 2008 3-Nitrotyrosine (3-NT) is a marker of protein nitration in physiological systems. It is present as 3-nitrotyrosine residues in proteins of tissue, extracellular matrix, plasma, and other body fluids and food.
Rabbani, Naila +3 more
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Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation [PDF]
, 2015 © The Royal Society of Chemistry 2015. A new chemical derivatisation method to functionalise peptide and protein bound 3-nitrotyrosine residues is described.
Ng, John Y., Wong, Jason W.H.
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Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins
Frontiers in Chemistry, 2022 A critical step in developing therapeutics for oxidative stress-related pathologies is the ability to determine which specific modified protein species are innocuous by-products of pathology and which are causative agents.
Elise M. Van Fossen +8 more
doaj +1 more source
3-Nitrotyrosine Modified Proteins in Atherosclerosis [PDF]
Disease Markers, 2015 Cardiovascular disease is the leading cause of premature death worldwide, and atherosclerosis is the main contributor. Lipid-laden macrophages, known as foam cells, accumulate in the subendothelial space of the lesion area and contribute to consolidate a chronic inflammatory environment where oxygen and nitrogen derived oxidants are released ...
openaire +2 more sources
Nitrotyrosine inhibits cell growth. [PDF]
(A & B) Cytotoxicity of nitrotyrosine. A549 (A) or HEp-2 (B) cells were cultured in normal medium (control) or in medium supplemented with nitrotyrosine (A, 400 μM; B, 25–400 μM; control cells received the HCl solvent for nitrotyrosine) for 144 h.
Bohdan Wasylyk (69613) +7 more
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Increased nitrotyrosine production in patients undergoing abdominal aortic aneurysm repair [PDF]
, 2004 NoVascular inflammation is implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm (AAA), and is thought to involve reactive species such as the nitric oxide-derived oxidant peroxynitrite.
Naseem, Khalid M. +2 more
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High Salivary 3-Nitrotyrosine Levels in Periodontitis. [PDF]
J Clin MedBackground: Tyrosine, a non-essential amino acid involved in protein biosynthesis, can undergo oxidative modification upon exposure to reactive species like the peroxynitrite radical (ONOO−), resulting in the formation of 3-nitrotyrosine (3-NT). High concentrations of 3-NT have been found in the periodontal tissues of rats with periodontitis and in one
Lorente L +9 more
europepmc +4 more sources
LRP blocked iNOS expression and nitrotyrosine after stroke. [PDF]
, 2013 A and C. Representative protein bands of iNOS and quantitative results in the penumbra are shown for control ischemia. B and D. Representative protein bands of iNOS in the penumbra and quantitative results for the animals receiving control ischemia and ...
Chuancheng Ren (333501) +3 more
core +1 more source