Results 171 to 180 of about 65,998 (238)

Up to Four‐Year Outcomes of Single‐Fraction Stereotactic Radiosurgery for Small Brain Metastases: A Competing‐Risk Analysis

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Introduction Single‐fraction stereotactic radiosurgery (SRS) is recommended for small brain metastases (< 2 cm). However, long‐term outcomes accounting for competing risks—particularly death, which precludes observation of local treatment failure (LTF)—remain limited. Methods We retrospectively analyzed cumulative incidences of LTF, defined as
Isabella Gruber, Oliver Koelbl
wiley   +1 more source

A Phase I/II Study of Ibrutinib Plus Trastuzumab in HER2‐Positive Metastatic Breast Cancer

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Ibrutinib has demonstrated inhibition of ErbB/HER tyrosine kinases in preclinical models. This Phase I/II study investigated the safety, efficacy, and immunomodulatory effects of ibrutinib in combination with trastuzumab in patients with HER2‐positive metastatic breast cancer (MBC) whose disease had progressed on ado‐trastuzumab emtansine ...
Joyce O'Shaughnessy   +10 more
wiley   +1 more source

Predicting Poor Efficacy of Cabozantinib in Advanced Renal Cell Carcinoma by Exploratory Metabolic Pathway Analysis and In Vitro Verification

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Cabozantinib (CABO) is currently an essential drug for first‐line and sequential therapy in the treatment of advanced renal cell carcinoma (RCC). Predicting its therapeutic efficacy will enable efficient drug selection and improve the prognosis of patients.
Takanari Sakai   +10 more
wiley   +1 more source

The Impact of the G8 Score on Survival Outcomes in Patients With Head and Neck Cancer Undergoing Concurrent Radiotherapy With Cetuximab due to Contraindications With Cisplatin

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Purpose Patients unable to receive cisplatin due to age, comorbidities, or reduced performance status are commonly treated with concurrent radiotherapy (RT) and cetuximab. This study evaluated the prognostic significance of the Geriatric 8 (G8) score and the Charlson Comorbidity Index (CCI) in predicting survival outcomes in this population ...
Esin Kiraz   +5 more
wiley   +1 more source

Clinical Impact of Nivolumab in Sinonasal Mucosal Melanoma: A 14-Year Single-Center Retrospective Study and Comprehensive Literature Review. [PDF]

open access: yesCancers (Basel)
Terazawa K   +14 more
europepmc   +1 more source

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