Results 181 to 190 of about 33,846 (277)

Formulasi dan karakterisasi Bromelain-Modified Nanostructured Lipid Carriers (NLC) dan uji mukolitiknya

Penghantaran obat secara oral memiliki masalah yaitu adanya penghalang berupa mukus. Penghalang mukus tersebut dapat diatasi dengan sistem pembawa yang efektif, yaitu Nanostructured Lipid Carriers (NLC). Kemampuan penetrasi NLC dapat dimaksimalkan dengan
Fajri Arifati, Vina
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Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery. [PDF]

Adv Sci (Weinh)
Nie Q, Liu J, Zhao X, Yang S, Sun H, Jia B, Ren X, Chen X, Sun L, Wu L, Wang C, Zhang J.   +11 more
europepmc   +1 more source

Zdhhc14 promotes pyroptosis in the dorsal root ganglion of oxaliplatin‐induced peripheral neuropathy mice by enhancing GBP5 palmitoylation and suppressing its ubiquitination

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Oxaliplatin‐induced up‐regulation of Zdhhc14 enhances GBP5 stability through palmitoylation‐dependent inhibition of ubiquitin–proteasome degradation, thereby contributing to the development of peripheral neuropathy. Zdhhc14 is identified as a key palmitoyltransferase up‐regulated in oxaliplatin‐induced peripheral neuropathy.
Xiao Jiang, Wanqiu Li, Yanzhuo Liu, Wei Song, Xuedan Zheng, Liu Tang   +5 more
wiley   +1 more source

Ion- and pH-Responsive In Situ Gel Incorporating Luteolin-Loaded Nanostructured Lipid Carriers Enhances Ocular Bioavailability and Anti-Angiogenic Efficacy for Corneal Neovascularization. [PDF]

Pharmaceutics
Ji Y, Liang Z, Yang J, Pu G, He X, Jiang M, Wu T, Zhang J, Zhou T, Wang Y.   +9 more
europepmc   +1 more source

Predicting cardiovascular disease in peritoneal dialysis patients using glycated proteomics and machine learning: A prospective multicentre study

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Graphical Headlights 1. Glycated proteomics identified candidate cardiovascular biomarkers in peritoneal dialysis patients. 2. A machine learning model integrated two glycated peptides with six clinical indicators. 3. The model achieved ROC‐AUCs of 0.781 in the internal testing set and 0.822 in multicentre external validation.
Ji Ji, Zhaoying Nie, Na Jiang, Ting Xie, Lei Zhang, Xiaoyan Liu, Min Lu, Bo Xiang, Weiwei Wu, Xiaotian Jiang, Lin Zhang, Jun Ji, Jianzhou Zou, Xiaoqiang Ding, Haojie Lu, Xiaofang Yu   +15 more
wiley   +1 more source

Development of Membrane Transport-Inspired Biomimetic System to Degrade Plasticizers. [PDF]

Chem Asian J
Mandal R, Sar S, Maiti T, Hazra B, Prasad M, Biswas S, Tarafdar PK.   +6 more
europepmc   +1 more source

Envenomation Leads to Venom Protein Reduction and a Recovery Period in Bumblebee Workers

Ecology and Evolution, Volume 16, Issue 11, November 2026.
The evolution and deployment of venom systems in social bees have been central to their ecological success, though not without costs. However, for species such as bumblebees, where stinging is not apparently fatal, it raises the question of what, if any, are the consequences associated with venom usage (envenomation).
Safira Moog, Mario Dejung, Amitkumar Fulzele, James C. Carolan, Thomas J. Colgan   +4 more
wiley   +1 more source

Epidemiological profile of leprosy cases at Nazareti Leprosy Center, Tanzania: A retrospective analysis (2000-2024). [PDF]

PLoS Negl Trop Dis
Machang'u R, Kagesyeko JN, Edward M, Ameh WO, Chuwa L, Upunda G, Tibenderana JR.   +6 more
europepmc   +1 more source

Enantiomeric excess bupivacaine in a lavender oil NLC tested in a melanoma model : prolonged release and anticancer effect

Recent studies have highlighted the potential of local anesthetics (LA) as adjuvants in cancer treatment, specifically by increasing survival rates when used in surgical excisions.
Silva, Gustavo Henrique Rodrigues da, Carvalho, Fabíola Vieira de, Araújo, Bibiana Verlindo de, Reis, Luccas Lavareze dos, De Paula, Eneida, Mendonça, Talita Cesarim, Geronimo, Gabriela, Moura, Ludmilla David de, Olivo, Laura Ben, Dalla Costa, Teresa Cristina Tavares, Mariano, Fernanda Viviane   +10 more
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