Results 61 to 70 of about 7,196 (266)

Lipid-based nanocarriers provide prolonged anticancer activity for palbociclib: In vitro and in vivo evaluations

Acta Medica Iranica, 2021
Breast cancer therapy has remained as one of the major healthcare challenges. Based on the critical role of cyclin-dependent Kinase 4/6 (CDK 4/6) in cell cycle progression, targeting this signaling appears promising for cancer therapy.
Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Rostami   +2 more
doaj   +1 more source

Tunability of the NLC Final Focus system [PDF]

PACS2001. Proceedings of the 2001 Particle Accelerator Conference (Cat. No.01CH37268), 2002
The performance of the new NLC Final Focus system has been investigated as a function of the incoming beam characteristics, such as energy, emittances, energy spread. A preliminary study of the tolerances and the tunability of the system is presented in this paper.
Raimondi, P, Seryi, A, Tenenbaum, P
openaire   +2 more sources

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule

Molecules, 2021
A novel formulation based on nanostructured lipid carriers (NLCs) was developed to increase solubility and intestinal absorption of khellin. K-NLCs were prepared with stearic acid, hempseed oil, Brij S20, and Labrafil M 1944 CS, using the emulsification ...
Giulia Vanti, Lucrezia Muti, Mario D’Ambrosio, Lucia Grifoni, Maria Camilla Bergonzi, Cristina Luceri, Anna Rita Bilia   +6 more
doaj   +1 more source

Surface and axis models of NLCs: oblique and overhead views (subject #17).

, 2016
Surface and axis models of NLCs: oblique and overhead views (subject #17).
Lucia Jañez-Garcia (3169641), Luis Jañez-Escalada (3169644), Jose M. Ramirez-Sebastian (3169656), Federico Saenz-Frances (3169653), Nicolas Toledano-Fernandez (3169650), Maria Urbasos-Pascual (3169647)   +5 more
core   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Nanostructured lipid carriers (NLCs): A comprehensive review of drug delivery advancements [PDF]

Background: Nano-structured lipid carriers (NLCs) have emerged as a significant advancement in lipid-based drug delivery systems. Compared to Solid Lipid Nanoparticles (SLNs), NLCs offer improved drug loading capacity, stability, and controlled release ...
Kumar, Saurabh, Panwar, Pramesh, Jakhmola, Vikash, Chauhan, Ashish Singh, Chand, Pallavi   +4 more
core   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study [PDF]

, 2015
This study describes the preparation, characterization, and in vivo evaluation in rats of nanostructured lipid carriers (NLCs) encapsulating rimonabant (RMN) as prototypical cannabinoid antagonist.
Mariani, Paolo, Patrizia Ratano, Nastruzzi C., Paolo Mariani, TREZZA, VIVIANA, Ravani L., Contado, Catia, Drechsler M., Nastruzzi, Claudio, Ruokolainen, Janne, Patrizia Campolongo, Trezza V., Viviana Trezza, Cortesi, Rita, Contado C., Esposito, Elisabetta, Campolongo, Patrizia, Drechsler, Markus, Esposito E., Mariani P., Cortesi R., Ravani, Laura, Ratano, Patrizia, MarkusDrechsler, Janne Ruokolainen, Contado Catia, Drechsler Markus, Mariani Paolo, Trezza Viviana, Campolongo Patrizia, Ruokolainen Janne, Esposito Elisabetta, Cortesi Rita, Nastruzzi Claudio, Ratano Patrizia, Ravani Laura   +35 more
core   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source