Results 81 to 90 of about 7,196 (266)

Enhancing Public School Funding Impact: How to Better Position the NLCS Career Center [PDF]

North Lawrence Community Schools (NLCS) wanted to explore ways to maximize the effectiveness of public funding. Graduate accounting students from the Kelley School of Business completed a review of the NLCS Career Center analyzing market fit and ...
Chambers, Andrew, Strycker, Sam, Smith, Hunter, Ruth, Tommy   +3 more
core   +1 more source

Targeting delivery of simvastatin using ICAM-1 antibody-conjugated nanostructured lipid carriers for acute lung injury therapy

Drug Delivery, 2017
Acute lung injury (ALI) is a critical illness without effective therapeutic modalities currently. Recent studies indicated potential efficacy of statins for ALI, while high-dose statins was suggested to be significant for attenuating inflammation in vivo.
Shu-Juan Li, Xiao-Juan Wang, Jing-Bo Hu, Xu-Qi Kang, Li Chen, Xiao-Ling Xu, Xiao-Ying Ying, Sai-Ping Jiang, Yong-Zhong Du   +8 more
doaj   +1 more source

Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. [PDF]

PLoS ONE, 2011
AIMS: Because hepatic cancer stem cells (HCSCs) are believed to derive from the conversion of hepatic normal stem cells (HNSCs), the identification of the differences that distinguish HCSCs from HNSCs is important.
Wei-hui Liu, Kai-shan Tao, Nan You, Zheng-cai Liu, Hong-tao Zhang, Ke-feng Dou   +5 more
doaj   +1 more source

Supersymmetry at LHC and NLC [PDF]

Nuclear Physics B - Proceedings Supplements, 1998
This talk discusses the prospects for supersymmetry studies at the LHC and NLC. The results are based on those of the Supersymmetry Working Group at the 1996 Snowmass Workshop.
openaire   +2 more sources

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured lipid carriers

International Journal of Nanomedicine, 2012
Yan Chen, Lei Zhou, Ling Yuan, Zhen-hai Zhang, Xuan Liu, Qingqing WuKey Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, Jiangsu, ChinaBackground: Nanostructured lipid carriers ...
Chen Y, Zhou L, Yuan L, Zhang ZH, Liu X, Wu QQ   +5 more
doaj  

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

The NLC injector system

Proceedings of the 1999 Particle Accelerator Conference (Cat. No.99CH36366), 2003
The Next Linear Collider (NLC) injector system is designed to produce low emittance, 10 GeV electron and positron beams at 120 hertz for injection into the NLC main linacs. Each beam consists of a train of 95 bunches spaced by 2.8 ns; each bunch has a population of 1.15/spl times/10/sup 10/ particles.
Bharadwaj, V., Clendenin, J. E., Emma, P., Frisch, J., Jobe, R., Kotseroglou, T., Krejcik, P., Kulikov, A. V., Li, Z., Maruyama, T., Millage, K. K., McKee, B., Mulhollan, G., Munro, M. H., Rago, C. E., Raubenheimer, T. O., Ross, M. C., Phinney, N., Schultz, D. C., Sheppard, J. C., Spencer, C. M., Vlieks, A. E., Woodley, M. D., van Bibber, K., Takeda, S.   +24 more
openaire   +2 more sources

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source