Results 11 to 20 of about 191,890 (217)

Diverse NLR immune receptors activate defence via the RPW8‐NLR NRG1 [PDF]

New Phytologist, 2019
Summary Most land plant genomes carry genes that encode RPW8‐NLR Resistance (R) proteins. Angiosperms carry two RPW8‐NLR subclasses: ADR1 and NRG1. ADR1s act as ‘helper’ NLRs for multiple TIR‐ and CC‐NLR R proteins in Arabidopsis. In angiosperm families, NRG1 co‐occurs with TIR‐NLR Resistance (R) genes.
Castel, Baptiste, Ngou, Pok‐Man, Cevik, Volkan, Redkar, Amey, Kim, Dae‐Sung, Yang, Ying, Ding, Pingtao, Jones, Jonathan D. G.   +7 more
openaire   +5 more sources

The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage

Frontiers in Immunology, 2023
Background Inflammatory mechanisms play important roles in intracerebral hemorrhage (ICH) and have been linked to the development of stroke-associated pneumonia (SAP).
Rui-Hong Wang, Wan-Xin Wen, Zerui Jiang, Zhenping Du, Zhao-hui Ma, Aili Lu, Huiping Li, Fang Yuan, Shibiao Wu, Jian-wen Guo, Ye-Feng Cai, Yan-Jun Huang, Li-xin Wang, Hongji Lu   +13 more
semanticscholar   +1 more source

The NLR gene family: from discovery to present day

Nature reviews. Immunology, 2023
The mammalian NLR gene family was first reported over 20 years ago, although several genes that were later grouped into the family were already known at that time.
W. Chou, Sushmita Jha, M. Linhoff, J. Ting   +3 more
semanticscholar   +1 more source

NLR receptors in plant immunity: making sense of the alphabet soup

EMBO Reports, 2023
Plants coordinately use cell‐surface and intracellular immune receptors to perceive pathogens and mount an immune response. Intracellular events of pathogen recognition are largely mediated by immune receptors of the nucleotide binding and leucine rich ...
Mauricio P. Contreras, Daniel Lüdke, Hsuan Pai, AmirAli Toghani, S. Kamoun   +4 more
semanticscholar   +1 more source

NLR we there yet? Nucleocytoplasmic coordination of NLR‐mediated immunity

New Phytologist, 2022
SummaryPlant intracellular nucleotide‐binding leucine‐rich repeat immune receptors (NLRs) perceive the activity of pathogen‐secreted effector molecules that, when undetected, promote colonisation of hosts. Signalling from activated NLRs converges with and potentiates downstream responses from activated pattern recognition receptors (PRRs) that sense ...
Daniel Lüdke, Qiqi Yan, Philipp F. W. Rohmann, Marcel Wiermer   +3 more
openaire   +3 more sources

Unsolved Mysteries in NLR Biology [PDF]

Frontiers in Immunology, 2013
NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors. Although most NLRs play some role in immunity, their functions range from regulating antigen presentation (NLRC5, CIITA) to pathogen/damage sensing (NLRP1, NLRP3, NLRC1/2, NLRC4) to suppression or modulation of inflammation (NLRC3, NLRP6, NLRP12, NLRX1). However, NLRP2,
Lupfer, Christopher, Kanneganti, Thirumala-Devi   +1 more
openaire   +3 more sources

Association between neutrophil percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and long-term mortality in community-dwelling adults with heart failure: evidence from US NHANES 2005–2016

BMC Cardiovascular Disorders, 2023
Background Heart failure (HF) continues to be the major cause of hospitalizations. Despite numerous significant therapeutic progress, the mortality rate of HF is still high.
Chia-Chen Wu, Chia-Hui Wu, Chien-Ho Lee, Cheng-I Cheng   +3 more
semanticscholar   +1 more source

Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Plant immunity involves defense activation upon pathogen perception by both cell-surface and intracellular NLR immune receptors. Most plant NLRs detect and respond to pathogen effectors, whereas “helper” NLRs transduce signals initiated by ...
J. Feehan, Junli Wang, Xinhua Sun, Jihyeon Choi, Hee‐Kyung Ahn, Bruno Pok Man Ngou, J. Parker, Jonathan D. G. Jones   +7 more
semanticscholar   +1 more source

Baseline and early changes in the neutrophil-lymphocyte ratio (NLR) predict survival outcomes in advanced colorectal cancer patients treated with immunotherapy.

International Immunopharmacology, 2023
BACKGROUND Systemic inflammation plays a role in carcinogenesis and is related to overall survival in patients with different cancer types, including those treated with immune checkpoint blockade (ICB). The neutrophil-lymphocyte ratio (NLR) is calculated
Hui Ouyang, Bijing Xiao, Yan Huang, Zhiqiang Wang   +3 more
semanticscholar   +1 more source

The impact of leprosy on the mental wellbeing of leprosy-affected persons and their family members – a systematic review

Cambridge Prisms: Global Mental Health, 2020
Leprosy has long-term consequences related to impairment and stigma. This includes a major impact on mental health. This study aims to consolidate current evidence regarding the mental health impact of leprosy on affected persons and their family members.
PMW Somar, MM Waltz, WH van Brakel
doaj   +1 more source