Results 21 to 30 of about 192,001 (267)

NLRs in immune privileged sites [PDF]

Current Opinion in Pharmacology, 2011
Innate immune receptors such as the nucleotide-binding domain, leucine-rich repeat-containing (NBD-LRR) receptors, referred to as NLRs, are known to serve as a critical component of host defense. However, their participation in inflammatory responses within immune privileged sites such as the brain and eye is less understood.
Holly L, Rosenzweig, Stephen R, Planck, James T, Rosenbaum   +2 more
openaire   +2 more sources

Association of neutrophil to lymphocyte ratio (NLR) with angiographic SYNTAX score in patients with non-ST-Segment elevation acute coronary syndrome (NSTE-ACS) [PDF]

Journal of Cardiovascular and Thoracic Research, 2021
Introduction: Considering the role of inflammation in pathogenesis of atherosclerosis, we aimed to investigate the association of presentation neutrophil to lymphocyte ratio (NLR) with complexity of coronary artery lesions determined by SYNTAX score in ...
Mehdi Maleki, Arezou Tajlil, Ahmad Separham, Bahram Sohrabi, Leili Pourafkari, Neda Roshanravan, Naser Aslanabadi, Farima Najjarian, Sina Mashayekhi, Samad Ghaffari   +9 more
doaj   +1 more source

Comparing Voluntary and Mandatory Gameplay

International Journal of Serious Games, 2016
Gameplay is commonly considered to be a voluntary activity. Game designers generally believe that voluntary gameplay is essentially different from mandatory gameplay. Such a belief may be a challenge for serious games, as instruction is usually mandatory.
Esther Kuindersma, Jelke van der Pal, Jaap van den Herik, Aske Plaat   +3 more
doaj   +1 more source

What Matters in the Effectiveness of Airborne Collision Avoidance Systems? Monte Carlo Simulation of Uncertainties for TCAS II and ACAS Xa

Aerospace, 2023
TCAS II is a rule-based airborne collision avoidance system (ACAS) that is used in current commercial air transport operations, and ACAS Xa is a new optimization-based system.
Sybert Stroeve
doaj   +1 more source

SOCIAL PARTICIPATION OF DIABETES AND EX-LEPROSY PATIENTS IN THE NETHERLANDS AND PATIENT PREFERENCE FOR COMBINED SELF-CARE GROUPS

Frontiers in Medicine, 2014
Introduction: Earlier we showed that neuropathic complications limit social participation of ex-leprosy patients, even in a non-endemic leprosy setting like the Netherlands.
Henry John Christiaan De Vries, Henry John Christiaan De Vries, Henry John Christiaan De Vries, Roos ede Groot, Wim H van Brakel   +4 more
doaj   +1 more source

Psychosocial burden of neglected tropical diseases in eastern Colombia: an explorative qualitative study in persons affected by leprosy, cutaneous leishmaniasis and Chagas disease

Cambridge Prisms: Global Mental Health, 2021
Background Leprosy, cutaneous leishmaniasis (CL) and Chagas disease (CD) are neglected tropical diseases (NTDs) with a high psychosocial burden in Norte de Santander and Arauca in Colombia.
Robin van Wijk, Lena van Selm, Martha C. Barbosa, Wim H. van Brakel, Mitzi Waltz, Karl Philipp Puchner   +5 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

NLR diversity, helpers and integrated domains: making sense of the NLR IDentity

Current Opinion in Plant Biology, 2017
Plant innate immunity relies on genetically predetermined repertoires of immune receptors to detect pathogens and trigger an effective immune response. A large proportion of these receptors are from the Nucletoide Binding Leucine Rich Repeat (NLR) gene family.
E, Baggs, G, Dagdas, K V, Krasileva
openaire   +2 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Leprosy post-exposure prophylaxis with single-dose rifampicin (LPEP): an international feasibility programme

The Lancet Global Health, 2021
Summary: Background: Innovative approaches are required for leprosy control to reduce cases and curb transmission of Mycobacterium leprae. Early case detection, contact screening, and chemoprophylaxis are the most promising tools.
Jan Hendrik Richardus, ProfPhD, Anuj Tiwari, PhD, Tanja Barth-Jaeggi, PhD, Mohammad A Arif, MD, Nand Lal Banstola, MBA, Rabindra Baskota, MD, David Blaney, MD, David J Blok, PhD, Marc Bonenberger, PhD, Teky Budiawan, MD, Arielle Cavaliero, MPH, Zaahira Gani, MSc, Helena Greter, PhD, Eliane Ignotti, ProfPhD, Deusdedit V Kamara, MD, Christa Kasang, PhD, Pratap R Manglani, MD, Liesbeth Mieras, MD, Blasdus F Njako, MD, Tiara Pakasi, MA, Basu Dev Pandey, PhD, Paul Saunderson, PhD, Rajbir Singh, MD, W Cairns S Smith, ProfPhD, René Stäheli, MSc, Nayani D Suriyarachchi, MD, Aye Tin Maung, MD, Tin Shwe, MD, Jan van Berkel, MA, Wim H van Brakel, PhD, Bart Vander Plaetse, MD, Marcos Virmond, ProfPhD, Millawage S D Wijesinghe, MD, Ann Aerts, MD, Peter Steinmann, PhD   +34 more
doaj   +1 more source