Results 231 to 240 of about 192,001 (267)

The NLR-related disorders

Seminars in Immunopathology, 2007
The present issue, which is dedicated to the NOD-like receptors (NLRs), is particularly timely since there is burgeoning evidence that these molecules play a pivotal role in an expanding number of monogenic and polygenic disease. At the molecular level the NLR family of molecules plays a key role as pattern recognition receptors for intracellular ...
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Indirect recognition of pathogen effectors by NLRs

Essays in Biochemistry, 2022
Abstract To perceive pathogen threats, plants utilize both plasma membrane-localized and intracellular receptors. Nucleotide-binding domain leucine-rich repeat containing (NLR) proteins are key receptors that can recognize pathogen-derived intracellularly delivered effectors and activate downstream defense.
Kevin Ao, Xin Li
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Method to Measure Ubiquitination of NLRs

2016
Posttranslational modifications are crucial in determining the functions of proteins in the cell. Modification of the NLRP3 inflammasome by the ubiquitin system has recently emerged as a new level of regulation of the inflammasome complex. Here, we describe a method to detect polyubiquitination of NRLP3 using two different approaches: (1) detection ...
Palazón, Pablo, Lopez-Castejon, Gloria
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The Prognostic Value of the Neutrophil–Lymphocyte Ratio (NLR) in Acute Pancreatitis: Identification of an Optimal NLR

Journal of Gastrointestinal Surgery, 2013
The neutrophil-lymphocyte ratio (NLR), calculated from the white cell differential count, provides a rapid indication of the extent of an inflammatory process. The aim of this study was to investigate the prognostic value of the NLR in acute pancreatitis (AP) and determine an optimal ratio for severity prediction.NLRs were calculated on days 0, 1, and ...
Aravind, Suppiah, Deep, Malde, Tameem, Arab, Mazin, Hamed, Victoria, Allgar, Andrew M, Smith, Gareth, Morris-Stiff   +6 more
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NLR functions beyond pathogen recognition

Nature Immunology, 2011
The last 10 years have witnessed the identification of a new class of intracellular pattern-recognition molecules--the nucleotide-binding domain and leucine-rich repeat-containing family (NLR). Members of this family garnered interest as pattern-recognition receptors able to trigger inflammatory responses against pathogens.
Kufer, Thomas A, Sansonetti, Philippe J
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The role of NLRs and TLRs in the activation of the inflammasome

Expert Opinion on Biological Therapy, 2008
Interleukin-1 beta is one of the most important pro-inflammatory cytokines. In contrast to other cytokines, activation of IL-1 beta requires processing from an inactive precursor by the cysteine protease caspase-1. Caspase-1 forms a protein platform called the inflammasome, together with proteins of the nucleotide-binding oligomerization domain-like ...
Netea, M.G., van de Veerdonk, F.L., Kullberg, B.J., van der Meer, J.W.M., Joosten, L.A.B., Joosten, L.A.B.   +5 more
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Atypical NLR pairs in wheat: Sensor–helper NLRs conferring disease resistance

Journal of Integrative Plant Biology
This commentary discusses new research showing that six structurally and functionally atypical NLR pairs in wheat confer disease resistance via a sensor NLR-helper NLR module. The functional mechanisms of some NLR pairs differ from the classical NLR pair model, revealing the complexity and diversity of the wheat immune system.
Yanbin Guan, Xuening Zhang, Zabta Khan Shinwari, Jian Chen, Guang Qi, Fengquan Liu, Huan Chen   +6 more
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NLRs at the intersection of cell death and immunity

Nature Reviews Immunology, 2008
Inflammation is a crucial element of the host response to cellular insult. Pathogen-induced inflammation includes a molecular pathway which proceeds through activation of the protease caspase-1 to the release of the inflammatory cytokines interleukin-1 (IL-1) and IL-18. Importantly, pathogens may also induce forms of cell death that have inherently pro-
Jenny P-Y, Ting, Stephen B, Willingham, Daniel T, Bergstralh   +2 more
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Dual Regulation of NLR Activation by Phosphorylation

Trends in Plant Science, 2020
The arabidopsis paired RRS1/RPS4 immune receptor complex has an essential role in resistance against several pathogens. A recent study by Guo et al. found that specific phosphorylation of RRS1-R reconfigures the complex, thereby activating the resistance reaction.
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Functional Reconstruction of NLRs in HEK293 Cells

2016
Inflammasomes are molecular complexes that initiate innate immune response. They are mainly expressed by immune cells; however, molecular manipulations in these cells remain very difficult. Here, we describe a simple protocol to overexpress and activate functional NRLP3 inflammasomes in HEK293 cells.
Compan, Vincent, Lopez-Castejon, Gloria
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