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Molecular actions of NLR immune receptors in plants and animals
Science China Life Sciences, 2020NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis
Wang, J., Chai, J.
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The evolution of plant NLR immune receptors and downstream signal components
Current Opinion in Plant Biology, 2023Along with the emergence of green plants on this planet one billion years ago, the nucleotide binding site leucine-rich repeat (NLR) gene family originated and diverged into at least three subclasses. Two of them, with either characterized N-terminal toll/interleukin-1 receptor (TIR) or coiled-coil (CC) domain, serve as major types of immune receptor ...
Yang Liu +4 more
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Engineering NLR immune receptors for broad-spectrum disease resistance
Trends in Plant Science, 2013Two recent reports by Maekawa et al. and Narusaka et al. demonstrated the transfer of a nucleotide-binding domain and leucine-rich repeat (NLR) family of immune receptors into evolutionarily diverged plants without causing adverse fitness consequences.
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Recent advances of NLR receptors in vegetable disease resistance
Plant SciencePlants mainly depend on both cell-surface and intracellular receptors to defend against various pathogens. The nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular receptors that recognize pathogen effectors. The first NLR was cloned thirty years ago. Genomic sequencing and biotechnologies accelerated NLR gene isolation.
Qing, Wen +3 more
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Molecular studies on plant NLR immune receptors
2020In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) receptors play crucial roles in the recognition of pathogen-derived molecules and the activation of defense. Sensor NLRs (sNLRs) are polymorphic with the ability to recognize relatively diverse pathogenic effectors.
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Signal transduction pathways used by NLR-type innate immune receptors
Molecular BioSystems, 2008Proteins from the nucleotide-binding domain, LRR containing (NLR) family are involved in sensing bacterial invasion and danger signals in mammalian cells. Activation of these molecules leads to inflammatory responses which help clearance of invading pathogens. Recent data now shed light on the signal transduction pathways used by NLR proteins.
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AtCDC48A is involved in the turnover of an NLR immune receptor
The Plant Journal, 2016SummaryPlants rely on different immune receptors to recognize pathogens and defend against pathogen attacks. Nucleotide‐binding domain and leucine‐rich repeat (NLR) proteins play a major role as intracellular immune receptors. Their homeostasis must be maintained at optimal levels in order to effectively recognize pathogens without causing autoimmunity.
Charles, Copeland +3 more
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Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs
Current Opinion in Infectious Diseases, 2008The recent discovery of novel classes of receptors, including toll-like receptors and nucleotide-binding oligomerization domain (NOD)-like receptors is challenging the crucial role of the innate immune system in the recognition of Mycobacterium tuberculosis.
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Conserved transcription factors NRZ1 and NRM1 regulate NLR receptor-mediated immunity
Plant PhysiologyAbstract Plant innate immunity mediated by the nucleotide-binding leucine-rich repeat (NLR) class of immune receptors plays an important role in defense against various pathogens. Although key biochemical events involving NLR activation and signaling have been recently uncovered, we know very little about the transcriptional regulation ...
Qingling Zhang +7 more
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